Term
| what are the 4 types of AML? |
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Definition
| 1. genetic aberrations 2. MDS-like 3. therapy-related 4. NOS |
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Term
| what are the 4 types of genetic aberrations? |
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Definition
| t(8;21), inv(16), t(15;17), t(11q23) |
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Term
| what are the 2 drug categories that cause therapy-related AML? |
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Definition
| topoisomerase II inhbitors (etoposide, tenoposide) and alkylating agents |
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Term
| alkylating agents usually cause what cytogenetic defect that would lead to AML? |
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Definition
| deletion of chromosome 5 or 7 |
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Term
| topoisomerase II inhibitors usually cause what cytogenetic defect that would lead to AML? |
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Definition
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Term
| what is the single diagnostic criteria for AML? |
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Definition
| >20% myeloblasts in bone marrow |
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Term
| general tx strategy for AML |
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Definition
| RTK inhibitors to block proliferation + histone deacetylase inhibitors to allow maturation |
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Term
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Definition
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Term
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Definition
| good with chemotherapy and in absence of cKIT mutations |
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Term
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Definition
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Term
| pt presents with monocytic and myeloid blasts, and eosinophils; genetic mutation? |
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Definition
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Term
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Definition
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Term
| pt presents with high WBC, and high risk of DIC; what genetic mutation do you suspect? |
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Definition
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Term
| pt presents with low WBC and reniform nuclei; which AML is this? |
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Definition
| hypergranular variant of t(15;17) |
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Term
| cytogenetic analysis shows a FLT3 mutation; what fusion protein do you suspect you will find and what is the translocation? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| peripheral blood smear shows blasts of myeloid and monocytic series but no eosinophils; what translocation do you suspect? |
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Definition
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Term
| pt is positive for MLL fusion genes; what complications are you worried about if the pt's WBC count is low? |
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Definition
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Term
| hypogranular t(15;17) complication |
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Definition
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Term
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Definition
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Term
| what genetic defect do topoisomerase II inhibitors cause to induce AML? |
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Definition
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Term
| myeloid and monocytic blasts + eosinophils on peripheral blood smear; dx? translocation? |
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Definition
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Term
| tx: ATRA; dx? translocation? |
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Definition
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Term
| peripheral blood smear shows Auer rods, reniform nuclei; high WBC count; what complication is most likely to be involved? |
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Definition
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Term
| fluorescent staining for CBF-beta shows it sequestered in the cytoplasm of blast cells; what is the genetic mutation? what is the fusion protein? |
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Definition
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Term
| 4 pts with AML present with 4 different translocations; which one gives the worst prognosis? |
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Definition
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Term
| pseudo Pelger-Huet cell and ringed sideroblasts; dx? |
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Definition
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Term
| pt with MDS presents with 5q deletion; tx? |
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Definition
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Term
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Definition
| azacitidine (hypomethylating agent) + cytokines/growth factors |
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Term
| elevated monocyte count; dx? |
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Definition
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Term
| PMML with PDGFR-beta translocation; tx? |
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Definition
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Term
| 50yo man presents with a hypocellular bone marrow filled with reticular and collagen fibers; tx? |
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Definition
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Term
| pt presents with markedly elevated Hb, Jak2 mutation, and hypercellular bone marrow; dx? |
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Definition
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Term
| 65yo pt presents with Jak2 mutation, hypercellular bone marrow, and reduced EPO levels; tx? |
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Definition
| phlebotomy, aspirin+hydroxyurea |
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Term
| Jak2 mutation, low Hb, elevated platelets and megakaryocytes; dx? |
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Definition
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Term
| dry tap with enmeshed megakaryocytes; fibrotic bone marrow; dx? |
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Definition
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Term
| cancers that are surgically curable |
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Definition
| breast, prostate, uterine, head and neck, colo-rectal |
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Term
| epithelial cancers that are not surgical curable |
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Definition
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Term
| what epithelial cancers respond to chemotherapy? |
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Definition
| breast, small cell lung, ovary, colo-rectal |
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Term
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Definition
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