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| Active force of a muscle (contraction) |
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| force of object to be moved |
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| Tension must over come resistance |
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| Muscle can only _________ (tension) not _______ (compression) |
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| Skeletal Muscle is for ___________ |
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| Skeletal muscle is attached to |
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| Skeletal Muscle Functions |
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*Produce Movement of skeleton *Maintain body posture *support soft tissue *Guard entrances and exits (sphincter muscles) *Maintain Body Temperature |
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| Skeleton Attached to Muscle by _______ |
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| Skeletal Muscle Connective Tissue |
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*Epimysium *Perimysium *Endomysium |
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| *Separates muscle from other tissues/organs |
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*Muscle fibers called fascicle (bundles) *divided into compartments *where blood vessels are |
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*Divides fascicle into individual muscle fibers *arterioles around each fiber *ties adjacent fibers together |
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| embryonic cells that did not become muscle cells but can become muscle cells to repair damage |
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| Connective tissues join to become _________ (bundles) or _________ (sheet)to attach to bone |
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| Skeletal Muscle Muscle Fiber |
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*Multinucleated *Sarcolemma *Sarcoplasm *Transverse Tubules (TT) *Sarcoplasmic reticulum *Myofibrils |
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*Each Nucleus from myoblast origin *Fused Myoblasts form muscle fiber |
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| Muscle fiber cell membrane |
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| Narrow tubes continuous with sarcolemma, Contains extracellular fluid |
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*Similar to ER, connected to TT *Surrounds myofibrils *Contains extracellular fluid high in Ca-(2+) |
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*Bundles of Thick (myosin) and thin (actin) *Myofilaments (proteins) organized into sarcomere |
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| A Band stains dark due to |
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| I Band light staining due to |
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| center of A band where myosin held in place by protiens |
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| Area in A zone with myosin only |
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| where adjacent sarcomeress meet |
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| Myosin connected to Z line by _____ |
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| * Myosin 'heads' with ADP + P(sub i) form cross bridges to 'walk' along actin during muscle contraction |
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| Troponin/tropomyosin complex on actin prevents cross bridge formation |
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How does it work? Sliding Filament Theory? Step 1 |
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| Skeletal muscle stimulated to contract by nervous tissue |
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| At neuromuscular junction, nerve impulse causes acetylcholine (Ach) to be released into synapse |
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| Ach receptors on muscle change permeability of sarcolemma causing influx of Na+ into sarcoplasm |
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| Influx continues until acetylcolinesterase removes Ach from receptors |
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| Na+ causes Ca(2+) to be released from transverse tubules (TT) and sarcoplasmic reticulum |
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Ca(2+) attaches to troponin *exposing attachment site to actin |
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Step 7 Omit: extra card lalalalala |
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| Myosin head attaches to exposed site in actin forming cross-bridge using energy from ATP |
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| Myosin head (attached to actin) pivots towards M Line releasing ADP+P |
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| Release of ADP + P(sub i) detaches myosin head from actin |
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| Myosin head ready to form another cross-bridge with another actin using ATP |
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| "walking" will continue as long as Ca (2+) attaches to troponin exposing attachment site |
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| Muscle contracts (shortens) causing tension that pulls bone towards desired position |
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Acetylcholine released into neuromuscular junction is quickly broken down and/or reabsorbed via acetylcholinesterase to stop neurotransmission
*Ca(2+) is quickly actively pumped back into SR |
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| What if you run out of ATP? |
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You Will Die!!! muhahahhaha
*Extra ATP converted to CP (creatine phosphate) * When needed CPK (creatine phosphate) *Releases energy from CP to make ATP |
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*required for use of ATP and CP as energy source *Uses glucose, glycogen, oxygen, (myoglobin helps) *At rest, fatty acids used for ATP to make more glycogen, ATP and CP |
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*ATP and CP are used up *Pyruvate made in glycolysis cannot be fed into mitochondria fast enough |
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Anarobic respiration Result= |
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| build up of toxic lactic acid= BAD |
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| muscle cannot contract when stimulated by neurons |
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| muscles not used and become 'flabby' |
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| Cardiac Muscle Tissue is stimulated by... |
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| Cardiac pacemaker cells... Not Nervous System |
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| Nervous system can influence... |
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*connect adjacent cardiac muscle cells *To ensure all contract together |
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| What kind of energy does cardiac muscle use? |
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Aerobic metabolism ONLY (myoglobin helps) |
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*Most all organs *Spindle shape with single nucleus *Not striated *Myosin scatted throughout cell *Actin attached to dense bodies *Contraction causes muscle to 'twist' |
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