Term
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Definition
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Term
| key to vasculitis diagnosis |
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Definition
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Term
| systemic vasculitis symptoms |
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Definition
| fever, malaise, weight loss |
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Term
| vasculitis large vessel symptoms |
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Definition
| pulseless, blindness, CVA, syncope |
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Term
| vasculitis medium vessel symptoms |
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Definition
| CAD, renal artery, CVA, mononeuritis (wrist/foot drop) |
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Term
| vasculitis small vessel symptoms |
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Definition
| palpable purpura, Raynauds/gangrene |
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Term
| vasculitis large vessel classification |
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Definition
takayasu
temporal arteritis |
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Term
| vasculitis medium vessel classification |
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Definition
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Term
| vasculitis small vessel classification |
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Definition
churg-strauss syndrome
wegeners granulamatosis
henoch-schonlein purpura
hypersensitivity/cutaneous vasculitis
CVD associated vasculitis
Goodpastures syndrome
Behcet disease |
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Term
| vasculitic involvement of small cutaneous vessels |
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Definition
| leukocytoclastic vasculitis |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| aka leucocystoclastic vasculitis/allergic vasculitis |
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Definition
| hypersensitivity vasculitis |
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Term
| hypersensitivity vasculitis causes |
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Definition
viral/bacterial/atypical infections
medicine reactions
CVD or vasculitis
idiopathic |
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Term
| hypersensitivity vasculitis treatment |
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Definition
| find cause and stop/treat this |
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Term
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Definition
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Term
| necrotizing (caseating) granulomatous vasculitid disease |
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Definition
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Term
| typical onset at age 20-40 |
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Definition
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Term
| treatment of wegeners granulomatosis |
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Definition
| glucocorticoids and cyclophosphamide improves survival |
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Term
| wegeners granulmoatosis main sites of involvement |
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Definition
ELK.
ENT (UR, optic, Otic, sinusitis)
LRT
Kidney (GN) |
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Term
| main lab study for wegeners granulomatosis |
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Definition
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Term
| classification criteria for wegeners granulomatosis (must have 2/4) |
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Definition
1. nasal or oral inflammation
2. abnormal chest radiograph
3. urinary sediment (rbc)
4. granulomatous inflammation on biopsy |
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Term
| causes deformity of the nose secondary to granulomatous disease |
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Definition
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Term
| classification criteria for Churg-Strauss syndrome (must have 4/6) |
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Definition
1. asthma
2. eosinophila >10% wbc
3. mononeuropathy or polyneuropathy
4. transitory pulmonary infiltrates
5. paranasal sinus abnormality
6. biopsy with extravascular eosinophils |
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Term
| Vasculitis lab markers of inflammation |
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Definition
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Term
| vasculitis lab hematologic changes |
|
Definition
leukocytosis usually with neutrophilia
anemia
thrombocytosis |
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Term
| vasculitis lab complement levels |
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Definition
| depressed. consumption of complement proteins due to antibody binding |
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Term
| vasculitis lab high RF with low complements |
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Definition
hepatitis related PAN
in RA: most likely rheumatoid vasculitis
cryoglobulinemic vasculitis |
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Term
|
Definition
| anti-neutrophil cytoplasmic antibody |
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Term
| staining patterns of ANCA |
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Definition
cytoplasmic (c-ANCA)
perinuclear (p-ANCA) |
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Term
| vasculitis tissue biopsy from |
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Definition
| temporal artery, muscle, sural nerve, skin, nasal/sinus, lung, kidney |
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Term
|
Definition
| claudication/ischemic symptoms |
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Term
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Definition
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Term
| classification criteria: polyarteritis nodosa (3/10 required) |
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Definition
1. weight loss >4g
2. livedo reticularis
3. testicular pain or tenderness
4. myalgias, weakness, leg tenderness
5. mononeuropathy or polyneuropathy
6. diastolic bp >90 mmHG
7. elevated BUN or creatinine
8. hepatitis B virus
9. arteriographic abnormality
10. biopsy of small or medium artery containing PAN |
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Term
| polymyalgia rheumatica characteristics |
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Definition
older patient (over 50), caucasian, normal physical examination, aching/stiffness
muscle pain (shoulders/pelvic girdle) at least 1 month
severe morning stiffness and gelling |
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Term
| polymyalgia rheumatica DD possibilities |
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Definition
| temporal arteritis, viral myalgia, RA, polymyositis, multiple myeloma, OA, fibrositis, depression, occult infection, occult malignancy, endocrinopathy |
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Term
| Giant cell (temporal ) arteritis classification (3/5) |
|
Definition
1. over 50 at disease onset
2. new headache
3. temporal artery abnormality
4. elevated westergren ESR >50
5. abnormal artery biopsy with mononuclear cell infiltrate, granulmoatous inflammation, usually with multinucleated giant cells |
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Term
| secondary forms of vasculitis |
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Definition
| RA, SLE, lymphoma, other tumors, infectoin, drugs |
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