Term
| What are two factors responsible for uncontrolled colonal expansion of a cell? |
|
Definition
1) environmental factor
2) Virus Infections |
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|
Term
| What is the only protoncogene found to be mutated in the germline of patients predisposed to cancer? |
|
Definition
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|
Term
| What is the best known oncogene? |
|
Definition
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|
Term
| What was the first specific chromosomal translocation identified in human cancer? |
|
Definition
Philadelphia chromosome
*found in chronic myeloid leukemia |
|
|
Term
| What has led to dramatic responses in CML? |
|
Definition
| effective inhibitor of the brc-abl kinase |
|
|
Term
| What are two genomic stability genes? |
|
Definition
|
|
Term
| mutations of what gene are common in 50% of human cancers? |
|
Definition
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|
Term
| What two oncogenes are responsible for increased risk of ovarian and breast cancer? |
|
Definition
|
|
Term
| What is the most common genetic lesion that abrogates cell death response? |
|
Definition
| inactivation of p53 tumor suppressor |
|
|
Term
| What two things provide the essential components for malignant transformation? |
|
Definition
1) mutations
2) infinite lifespan |
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