Term
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Definition
| reversibility inhibits the growth of bacteria. |
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Term
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Definition
| kills the susceptible bacteria. |
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Term
| Minimum Inhibitory Concentration (MIC) |
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Definition
| lowest concentration of antibiotic that results in inhibition of visible growth (i.e. colonies on a plate or turbidity in broth) under standard conditions. |
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Term
| For an antibiotic to be effective... |
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Definition
| it must reach either MIC or MBC at the site of the infection. |
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Term
| Antibiotic is bactericidal |
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Definition
| if MIC and MBC are close in value. |
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Term
| Antibiotic is bacteriostatic |
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Definition
| if the MBC is much higher than the MIC |
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Term
| Minimum bactericidal concentration (MBC) |
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Definition
| the lowest concentration of the antibiotic that kills 99.9% of the original inoculum in a given time. |
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Term
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Definition
| bacterial strain inhibited by in vitro by a concentration of an antimicrobial agent that is associated with a high likelihood of therapeutic success. |
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Term
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Definition
| bacterial stain inhibited in vitro by a concentration of an antimicrobial agent that is associated with a high likelihood of therapeutic failure. |
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Term
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Definition
| Bacterial stain inhibited in vitro by a concentration of an antimicrobial agent that is associated with uncertain therapeutic effect. |
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Term
| Clinical and Laboratory Standards Institute (2013) |
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Definition
harmonized terminology database.
http://login.clsi.org/HTDatabase.cfm |
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Term
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Definition
| Pregnancy Cat. D. Not recommended for children under 9 years or for breast feeding mothers. |
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Term
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Definition
| not recommended for children under 18 years (except for inhalation antrax)or breast feeding mothers. |
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Term
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Definition
| are no recommended for third trimester of pregnancy. |
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Term
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Definition
| not recommended at term of pregnancy. |
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Term
| Monthly prescribing reference |
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Definition
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Term
| Inhibit Cell Wall Synthesis |
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Definition
Beta-lactams
Penicillin (+/- Beta lactamase inhibitors)
Cephalosporins (3 generations)
Monobactams
Carbapenems
Glycopeptides (Vancomycin, Telovavancin)
Fosfomycin (Manurol) |
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Term
| Inhibit Protein Synthesis |
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Definition
Aminoglycosides (Gentamycin, Tobramycin, Streptomycin, Kanamycin, Amikacin)
Macrolides & Ketolides (Erythromycin, Azithromicin, Clarithromycin, Telithromycin)
Lincosamides (Clindomycin Lincomycin)
Stretogramins (Synercid)
Tetracyclines (Tertracycline, Moncycline, Doxycycline)
Glycylcyclines (Tigercycline)
Phenicals (Chloromphenicol)
Oxazolidinones (Linezolid)
Ansamycins (Rifampin) |
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Term
| Inhibit Membrane Functions |
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Definition
Leptopeptides (Daptomycin)
Polymyxin |
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Term
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Definition
| Sulfonamides (Sulfamethoxazole/Trimethaprim, Sulfisoxazole) |
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Term
| Inhibit Nucleic Acid Synthesis |
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Definition
Fluoroquinolones (Ciprofloxacin, Levofloxacin, Moxifloxacin, Ofloxacin)
Furanes (Nitrofurantoin) |
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