Term
| M protein is an important virulence factor of Streptococcus pyogenes that inhibits phagocytosis. |
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Definition
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Term
| Acute glumerulonephritis occurs approximately 1-4 weeks following primary infection. |
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Definition
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Term
| Treatment of acute glomerulonephritis with penicillin is ineffective |
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Definition
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Term
Escherichia coli is one of the most common causes of urinary tract infections in women. |
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Definition
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Term
| Eshcerichia coli is one of the most common causes of neonatal meningitis and sepsis |
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Definition
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Term
| Eshcerichia coli is one of the most common causes of food poisoning |
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Definition
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Term
Eshcerichia coli is one of the most common causes of nosocomial infections |
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Definition
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Term
| Typhoid fever is caused by Salmonella typhi which is normal flora in many animals, especially poultry. |
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Definition
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Term
| The causatative agent in typhoid fever survives phagocytosis in the gut and can be isolated from blood cultures of infected individual |
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Definition
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Term
| During chronic infection of typhoid fever, the causative agent persistently colonizes the gall bladder. |
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Definition
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Term
| The causative agent in typhoid fever is most commonly transmitted by contaminated food and water |
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Definition
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Term
| Vaccine(s) are available for typhoid fever and recommended for traverlers who plan to visit endemic areas. |
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Definition
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Term
| Mycoplasma pneumoniae is one of the most common causes of atypical pneumonia in young adults, especailly in closed communities (i.e. boarding schools, military camps, prisons) |
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Definition
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Term
Infection of Mycoplasma pneumoniae does not result in life-long protective immunity. |
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Definition
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Term
| Mycoplasma pneumoniae is commonly transmitted from environmental water aerosol sources, such as air conditioners and water-cooling towers associated with larger buildings. |
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Definition
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Term
| Since Mycoplasma pneumoniae lacks a cell wall, penicillin is ineffective for treatment |
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Definition
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Term
| In common causes of meningitis in young adults, treatment with antibiotic as soon as possible is recommended because it is fatal more than 50% of the time if left untreated. |
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Definition
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Term
| The most common bacteria that cause minigitis are all members of the normal flora. |
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Definition
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Term
| Meningitis is a serious infectino because macrophages can not cross the blood brain barrier to cobat the infection |
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Definition
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Term
| Many meningitis infections can be treated with bacteriostatic antibiotics, but meningitis requires the use of bacteriocidal antibiotics. |
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Definition
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Term
| Aspergillus species are environmetnal fungi that grow in the soil as molds and in infected lung tissue as spherules. |
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Definition
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Term
| Cryptococcus neoformans is an environmental yeast that can cause meningitis in both immunocompetent and immunocompromised individuals |
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Definition
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Term
| Dermatophytes are opportunistic environmental molds that can cause serious systemic infection in patients with AIDS |
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Definition
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Term
| Rhizopus and Mucor, environmetnal molds that can contaminate cereals and nuts, produce aflatoxins which have been associated with hepatoma |
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Definition
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Term
Histoplasma capsulatum is a dimorphic fungi which grows as a mold in the soil of the eastern and midwestern USA |
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Definition
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Term
| Most people who live in the endemic areas have been infected by Histoplasma capsulatum |
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Definition
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Term
| Histoplasma capsulatum can produce tuberculosis-like lesions in the lungs and like mycobacterium tuberculosis it can survive phagocytosis and grow withing macrophages |
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Definition
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Term
| Histoplasma capsulatum produces a large polysaccharide capsule, which is an important virulence factor |
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Definition
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Term
| Histoplasma capsulatum is transmitted by the inhalation of air-borne conidia spores |
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Definition
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Term
| Coccidioides immitis is a dimorphic fungi which grows as a mold in the soild of the Central valley of California, the southwestern US, and Mexico |
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Definition
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Term
Most people who are exposed to Coccidiodes immitis have asymptomatic infections |
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Definition
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Term
Systemic infections with Coccidiodes immitis usually occurs first in the lungs and may disseminate to other tissues, including the meninges and skin |
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Definition
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Term
| Inhalation of respiratory droplets from asymptomatic carriers is a common mode of transmission in coccidiodomycosis |
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Definition
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Term
| Severe disseminated infections of coccidiodomycosis are commonly treated with amphotericin B |
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Definition
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Term
A gram negative rod shows up in a patient's blood sample who has bloody diarrhea as a symptom, what is the most likely cause of this? |
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Definition
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Term
| A coinfection of N. gonorrhoeae and C. trachomatis is uncommon |
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Definition
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Term
Penicillin G is the drug of choice for treating infection by either N. gonorrhoeae or C. trachomatis. |
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Definition
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Term
| Chlamydial infection is more prevalent in the US than gonoccocal infection |
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Definition
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Term
RPR and VDRL tests are rapid inexpensive screening tests that detect syphilis antibodies that fortitously cross-react with cardiolipin |
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Definition
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Term
| When performing the RPR and VDRL tests, false negative syphilis results sometiems occur if the antibody titer is high |
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Definition
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Term
| In latent syphilis the RPR, VDRL, and FTA-ABS tests are all positive |
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Definition
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Term
| Specific treponemal tests, like the FTA-ABS, that directly measure antibody to Treponema pallidum are used to confirm false negative RPR and VDRL results in syphillis |
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Definition
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|
Term
| The RPR and VDRL tests can be used to monitor treatment success or failure in syphillis since the titer of antibody decreases with successful treatment |
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Definition
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Term
| Due to the introudtion of the Group B streptococcal capsular polysaccharide vaccine the incidence of meningitis in neonates and infants has decreased significantly in the last 10 years. |
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Definition
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|
Term
| Presently the majority of acute meningitis cases are caused by Haemophilis influenzae |
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Definition
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Term
| Septicemia rarely precedes meningitis |
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Definition
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|
Term
| Bordetella pertussis is a common cause of meningitis in young infants |
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Definition
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|
Term
| Haemophilus influenzae is normal flora of the gastrointestinal tract and was the most common cause of meningitis in neonates prior to the introduction of the capsular polysaccharide vaccine |
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Definition
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|
Term
| The vaccine for Haemophilus influenzae is effective only against Haemophilus influenzae type b |
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Definition
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Term
Haemophilus influenzae is a common cause of otitis media (ear infection) of young children |
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Definition
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Term
| Haemophilus influenzae requires both X & V factors for growth and diagnosis frequently depends on isolation and culture |
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Definition
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|
Term
| Rifampin can be used for prophylaxis of Haemophilus influenzae in close contacts of the ill |
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Definition
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Term
| In ringworm, the characteristic erythema and vesicles of ringworm results from hypersensitivity reactions to fungal metabolites |
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Definition
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Term
In ringworm, hyphal cells are present only in the stratum corneum and do not penetrate the basal layers of the epithelium |
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Definition
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|
Term
| In ringworm, dermatophytes that cause ringworm grow only as hyphae, they are incapable of growth in the yeast form |
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Definition
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|
Term
| In ringworm, when serious secondary bacterial infection is present, antifungal therapy to eliminate the predisposing ringworm infection should be initiated first |
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Definition
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|
Term
| Ringworm can be acquired by exposure to shed skin scales from infected humans and other animals |
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Definition
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Term
| In oral thrus, the causative fungus is considered normal flora of the mouth and vaginal tract |
|
Definition
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|
Term
| In oral thrush, the causative fungus grows as a budding yeast that forms pseudohyphae when it invades tissue |
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Definition
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|
Term
| In oral thrush, a positive skin test indicates the presence of chronic infection. |
|
Definition
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|
Term
| Nystatin and ketoconazole are commonly used to treat oral thrus |
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Definition
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|
Term
All of the following are risk factors for Candida albicans infections: diabetes, broad spectrum antibiotic usage, HIV infection, pregnancy |
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Definition
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|
Term
Active immunization against Clostridium with toxoid vaccines is available to both tetanus and botulism, but not gas gangrene |
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Definition
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|
Term
| Clostridium botulinum, tetani, and perfingens are all associated with wound infections, but only botulinum is associated with food poisoning |
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Definition
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|
Term
| Clostridium botulinum and tetani are usually suceptible to penicillin, but perfingens is not |
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Definition
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|
Term
| Clostridium botulinum, tetani, and perfingens all produce exotoxins |
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Definition
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|
Term
| Corynebacterium diphtheriae is a pleomorphic Gram-positive rod |
|
Definition
|
|
Term
| cornebacterium diphtheriae is normal flora of the human upper respiratory tract |
|
Definition
|
|
Term
| The primary clinical symptoms of diphtheria are mediated by exotoxin |
|
Definition
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|
Term
| The DPT vaccine is used to simultaneously immunize individuals against diphtheria, pneumonia, and tetanus |
|
Definition
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|
Term
| Vaccination against diphtheria is extremely effective in that there are usually very few (<10cases/year) in the US |
|
Definition
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|
Term
During Hepatitis A virus infection, there are multiple serotypes, therefore reinfection is common |
|
Definition
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|
Term
During Hepatitis A virus infection, it is highly contagious because it is present at high titers in the blood of infected individuals |
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Definition
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|
Term
During Hepatitis A virus infection, no effective vaccine is presently available |
|
Definition
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|
Term
During Hepatitis A virus infection, virus is shed into the feces and infected individuals for approximately two weeks prior to the appearance of clinical symptoms. |
|
Definition
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|
Term
| HIV is a simple retrovirus, in that it lacks "accessory" genes that are commonly present in complex retroviruses |
|
Definition
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|
Term
| A few individuals who have chemokine receptors (CCR-5) on their T-lymphocytes appear to be resistant to HIV infection |
|
Definition
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|
Term
Reverse transcriptase mediates HIV viral integration into the host cell chromosome |
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Definition
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|
Term
| Since HIV has a low mutation rate only a few "variant" viral particles are produced during years of chronic infection |
|
Definition
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|
Term
| Regarding HPV, paillomaviruses are non-enveloped DNA viruses |
|
Definition
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|
Term
| Specific genotypes of HPV are associated with infection of specific tissues |
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Definition
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|
Term
| Frogs and reptiles are reservoirs for papillomaviruses that cause human warts |
|
Definition
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|
Term
| Specific genotypes of HPV are associated with malignant transformation (cancer) whereas other genotypes are not associated with malignancy |
|
Definition
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|
Term
| Only DNA viruses have been associated with oncogenesis, since integration of viral DNA is required for malignant transformation |
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Definition
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|
Term
| Oncogenes are unique genes found only in viruses |
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Definition
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|
Term
| Most oncogenes encode gene products that suppress cell proliferation |
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Definition
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Term
| The rate of cervical cancer is low in the USA because HPV infection is uncommon |
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Definition
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|
Term
| HPV infection is probably necessary for carcinoma, but insufficient (by itself), to cause malignant transformation |
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Definition
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|
Term
| The E6 and E7 proteins of HPV inactivate host molecules (p53 and RB) that regulate the rate of cellular proliferation |
|
Definition
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|
Term
| Smoking is an imporant co-factor associated with HPV-induced cervical cancer |
|
Definition
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|
Term
Most individuals who become infected with HBV resolve their primary infection and develop lifelong immunity |
|
Definition
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|
Term
| Most individuals who become persistently infected with HBV become asymptomatic cariers and serve as a reservoir for transmission to others |
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Definition
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|
Term
| Chronic hepatitis as a result of HBV infectionis a long term risk factors for the development of hepatocellular carcinoma |
|
Definition
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|
Term
| Recombivax, a live attenuated vaccine is available to prevent HBV infection |
|
Definition
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|
Term
Although it is a DNA virus, HBV utilizes a virally-encoded reverse transcriptase in its lifecycle |
|
Definition
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|
Term
| Detection of HBsAg (hepatitis B surface antigen) in the lood is an important diagnostic indicator of infection |
|
Definition
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|
Term
most of the liver damage seen in chronic HBV infection is due to the direct cytopathic effect of the virus on hepatocytes |
|
Definition
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|
Term
| Neonates of mothers with chronic HBV infection should be given both HBIG and active immunization |
|
Definition
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|
Term
| HCV infection is frequently asymptomatic |
|
Definition
|
|
Term
| HCV infection is primarily transmitted by exposure to infected blood |
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Definition
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|
Term
| Chronic infectiono with HCV occurs infrequently (<5%) following primary infection |
|
Definition
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|
Term
| HCV infection is the leading cause of liver transplants in the US |
|
Definition
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|
Term
| Presently, there is no vaccine to prevent HCV infection |
|
Definition
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|
Term
Infleunza viruses are non-enveloped RNA viruses |
|
Definition
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|
Term
| Most influenza pandemics are caused by influenza B virus |
|
Definition
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|
Term
| Rimantidine can be used as a prophylactic agent to limit the spread of influenza A virus in closed populations, such as nursing homes |
|
Definition
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|
Term
| Neuramidase spikes on the surface of influenza virus mediate its initial attachment and entry into host cells |
|
Definition
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|
Term
| Influenza A virus undergoes major antigenic changes (shifts) in its capside proteins, which allows the virus to evade existing immunity in the population |
|
Definition
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|
Term
Antigenic drift results from teh accumulation of point mutations in the RNA sequence of the viral genome |
|
Definition
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|
Term
| Antigenic shift results from homologous recombination of the nonsegmented RNA genome |
|
Definition
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|
Term
| Antigenic shift results from homologous recombination of the nonsegmented RNA genome |
|
Definition
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|
Term
| Antigenic shift usually occurs when a single host cell is co-infected with an influenza Group A and an influenza Group B strain of virus |
|
Definition
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|
Term
| Most emerging diseases are caused by "new" pathogens (eg. microbes that have not previously infected humans) |
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Definition
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|
Term
| Increased international travel is a significant factor contributing to the emergence/reemergence of some infectious diseases |
|
Definition
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|
Term
| Changes in weather, human demographics, and land use can all contribute to the emergence of infectious diseases |
|
Definition
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|
Term
| Failure to maintain adequate vaccination programs can result in the reemergence of infectious diseases |
|
Definition
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|
Term
| The acquisition of antibiotic resistance can lead to the reemergence of infectious diseases |
|
Definition
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|
Term
| Most individuals who are colonized with H pylori do not develop gastric ulcers |
|
Definition
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|
Term
| There is an association between H pylori infection and gastric carcinoma |
|
Definition
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|
Term
| Antacids are effective in treating duodenal ulcers because they neutralize the excess acid produced by H pylori |
|
Definition
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|
Term
| H pylori is primarily transmitted person to person |
|
Definition
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|
Term
| Although H pylori frequently causes bleeding into the gastrointestinal tract, it does not cause septicemia or disseminated disease |
|
Definition
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|
Term
Negative polarity RNA viruses found in spinal fluid requires entry of the nucleus in order to replicate in infected cells |
|
Definition
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|
Term
Negative polarity RNA viruses found in spinal fluid requires conversion of its genome into double-stranded DNA in order to produce viral proteins for replication in infected cells |
|
Definition
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|
Term
Negative polarity RNA viruses found in spinal fluid requires RNA-dependent RNA polymerase in its core in order to replicate itself in infected cells |
|
Definition
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|
Term
Negative polarity RNA viruses found in spinal fluid requires encoding of an aspartyl protease in its genome in order to replicate itself in infected cells |
|
Definition
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|
Term
Negative polarity RNA viruses found in spinal fluid requires enveloped characteristic transmitted by respiratory droplets in order to replicate itself in infected cells |
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Definition
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|
Term
-azole drugs can treat actinomycosis |
|
Definition
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|
Term
| -azole drugs can treat histoplasmosis |
|
Definition
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|
Term
| -azole drugs can treat cryptococcosis |
|
Definition
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|
Term
Secondary syphilis can be cultured in vitro from the site of damage |
|
Definition
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|
Term
| rheumatic fever can be cultured in vitro from the site of damage |
|
Definition
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|
Term
| glomerulonephritis can be cultured in vitro from the site of damage |
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Definition
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|
Term
| viral hepatitis caused by HCV can be cultured in vitro from the site of damage |
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Definition
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|
Term
| The influenza vaccine is a trivalent vaccine that contains two influenza A strains and one influenza B strain |
|
Definition
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|
Term
Re-immunization of the infleunza vaccine is recommended each year since a new vaccine is usually formulated each year to combat antigenic variation of influenza virus |
|
Definition
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|
Term
| Adults usually receive the live-attenuated "whole virus" vaccine, whereas children usually receive the killed "split virus" vaccine |
|
Definition
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|
Term
| High titers of antibody to hemagglutinin is the primary protective result of influenza immuniztion |
|
Definition
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|
Term
| The influenza vaccine is currently recommended for anyone who wants it |
|
Definition
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|
Term
Prions are unique infectious agents that do not contain RNA or DNA |
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Definition
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|
Term
| Prions are thought to be acquired by ingestion/eating |
|
Definition
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|
Term
| The brain is the primary site of pathological damage in prion-mediated diseases |
|
Definition
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|
Term
| Immunopathogenic mechanisms account for most of thee tissue damage observed in prion-mediated diseases |
|
Definition
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|
Term
| Mad Cow Disease is thought to be a prion-mediated disease |
|
Definition
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|
Term
| RSV is an enveloped RNA virus |
|
Definition
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|
Term
| RSV is the most common cause of bronchiolitis and pneumonia in infants |
|
Definition
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|
Term
| RSV commonly causes nosocomial outbreaks |
|
Definition
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|
Term
| In serious cases, passive immunization can reduce the severity and duration of disease |
|
Definition
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|
Term
| Human herpes virus type 8 establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China |
|
Definition
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|
Term
| Cytomegalovirus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China |
|
Definition
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|
Term
| Papillomavirus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China |
|
Definition
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|
Term
| Hepatitis B virus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China |
|
Definition
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|
Term
| Epstein-Barr virus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China |
|
Definition
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|
Term
| HSV-2 is a large enveloped DNA virus |
|
Definition
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|
Term
| HSV-2 can be inactivated by soap and water |
|
Definition
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|
Term
In HSV-2, life-long colonization occurs following primary infection |
|
Definition
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|
Term
Delivery by C-section, from mothers with active HSV-2 infection , is an option used to prevent severe disseminated infections in newborns |
|
Definition
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|
Term
| Treatment with ganciclovir can limit the severity and duration of vesicular lesions associated with reactivation |
|
Definition
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|
Term
| The presence of alpha-hemolytic streptococi in the throat is a predisposing factor for pneumonia |
|
Definition
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|
Term
viral respiratory tract infection is a predisposing factor for pneumonia |
|
Definition
|
|
Term
| Alcoholism is a predisposing factor for pneumonia |
|
Definition
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|
Term
| HIV infection is a predisposing factor for pneumonia |
|
Definition
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|
Term
| hospitilizationis a predisposing factor for pneumonia |
|
Definition
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|
Term
Inhibition of HIV viral attachment to host cell receptors is a likely chemotherapeutic agent to combat HIV |
|
Definition
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|
Term
Inhibition of viral reverse trancriptase activity is a likely chemotherapeutic agent to combat HIV infection |
|
Definition
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|
Term
| Inhibition of host ribosome binding and translation of viral encoded mRNA is a likely chemotherapeutic agent to combat HIV infection |
|
Definition
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|
Term
| Inhibition of viral aspartyl-protease activity is a likely chemotherapeutic agent to combat HIV infection |
|
Definition
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|
Term
| Inhibition of viral maturation mechanisms (core/capsid self-assembly) is a likely chemotherapeutic agent to combat HIV infection |
|
Definition
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|
Term
What is transmitted by saila, breast milk, blood urine, and sex? may cross the placenta and is the #1 cause of birth defects in the US May cause retinitis in severely immunocompromised patients
respiratory syncytial virus herpes simplex virus type 2 cytomegalovirus human immunodeficiency virus
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Definition
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|
Term
The spirochete that causes Lyme disease is transmitted to humans by infected ticks |
|
Definition
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|
Term
| Flue-like symptoms and a rash on the palms of the hands and soles of the feet are initial symptoms of Lyme Disease |
|
Definition
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|
Term
| Arthritis is a common manifestation of untreated Lyme Disease |
|
Definition
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|
Term
The incidence of Lyme Disease is probably vastly overdiagnosed |
|
Definition
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|
Term
| Hepatitis B virus is transmitted by sexual contact |
|
Definition
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|
Term
Treponema pallidum is transmitted by sexual contact |
|
Definition
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|
Term
| Papillomavirus is transmitted by sexual contact |
|
Definition
|
|
Term
| Herpes simplex type 2 is transmitted by sexual contact |
|
Definition
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|
Term
| Peole in isolated communities such as prisons are likely reservoirs for antigenic shift variants of influenza virus that cause pandemics |
|
Definition
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|
Term
| Pigs and chickens are likely reservoirs for antigenic shift variants of influenza virus that cause pandemics |
|
Definition
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|
Term
| Immunocompromised individuals are likely reservoirs for antigenic shift variants of influenza virus that cause pandemics |
|
Definition
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|
Term
Multinucleated cells or syncytia are observed in several viral infections because certain viruses stimulate host cell nuclear replication, but inhibit cell division |
|
Definition
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|
Term
| Multinucleated cells or syncytia are observed in several viral infections because some viral infections induce nuclear budding and cytoplasmic enlargement of host cell |
|
Definition
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|
Term
| Multinucleated cells or syncytia are observed in several viral infections because when host cells become immortalized by viruses they frequently grow larger |
|
Definition
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|
Term
| Multinucleated cells or syncytia are observed in several viral infections because virally encoded fusion proteins on the surface of infected host cells cause them to fuse together |
|
Definition
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|
Term
Multinucleated cells or syncytia are observed in several viral infections because viral oncogenes up-regulate the cyell cycle and cause uncontrolled host cell growth |
|
Definition
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|
Term
| Proteins on the surface of viral particles mediate attachment of the virus to specific receptors on the surface of host cells |
|
Definition
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|
Term
| The viral capsid disintegrates after viral particles enter the nucleus where translation of the viral genome takes place |
|
Definition
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|
Term
| Some viruses have an outer envelope composed of viral proteins and phospholipids derived from host cell membranes |
|
Definition
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|
Term
| Some viruses have surface proteins that can cause fusion of virally infected host cells |
|
Definition
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|
Term
| Rhinoviruses are small non-enveloped viruses with an RNA genome |
|
Definition
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|
Term
Rhinoviruses are transmitted by hand-tohand contact as well as by respiratory aerosols |
|
Definition
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|
Term
| Atypical pneumonia is a common complication of Rhinovirus infection in neonates |
|
Definition
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|
Term
| One reason that there is no vaccine for the "common cold" is that there are more than 100 serotypes of Rhinovirus |
|
Definition
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|
Term
| Rhinovirus is a picovirus |
|
Definition
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|
Term
Poliovirus is a picornavirus |
|
Definition
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|
Term
| Hepatitis A is a picorna virus |
|
Definition
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|
Term
Which of the following is leaset likey to be transmitted either in utero or at birth? Herpes simplex virus type 2 Measles virus Hepatitis B virus Human immunodeficiency virus Cytomegaly virus
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Definition
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|