Term
protein synthesis inhibitors (6)
3 examples |
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Definition
aminoglycosides
tetracyclines
macrolides e.g. erythromycin
lincosamides e.g. clindomycin
chloramphenicol
oxazolidinones e.g. linezolid |
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Term
| folate metabolism inhibitors (2) |
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Definition
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Term
| nucleic acid biosynthesis inhibitors (2) |
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Definition
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Term
| peptide bonds are formed in which subunit? |
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Definition
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Term
| small ribosomal subunit monitors |
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Definition
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Term
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Definition
streptomycin
gentamicin
amikacin
tobramycin |
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Term
| _ + _ combo is effective against enterococci |
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Definition
aminoglycoside
beta lactam |
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Term
| mechanism of aminoglycosides |
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Definition
| bind small ribosomal subunit --> reduced accuracy |
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Term
| primary mechanism of aminoglycoside resistance _ by _ |
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Definition
inactivation
adenylation
phosphorylation
acetylation |
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Term
| streptomycin is part of what group? |
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Definition
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Term
| a common mechanism of streptomycin resistance to aminoglycosides |
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Definition
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Term
| what group is intrinsically resistant to aminoglycosides? why? |
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Definition
anaerobic bacteria
uptake depends on "electron transport to oxygen" |
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Term
| tetracyclines mostly differ in _ not _ |
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Definition
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Term
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Definition
| prevent binding of tRNA to ribosome |
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Term
| is resistance to tetracycline common? |
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Definition
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Term
| major mechanism of tetracycline resistance |
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Definition
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Term
| mechanisms of tetracycline resistance (one is major) |
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Definition
pumped out (major)
protein that binds tetracycline |
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Term
| erythromycin is an example of a |
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Definition
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Term
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Definition
| block exit tunnel of large ribosomal subunit |
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Term
| 12 drugs of antimicrobial chapter II and whether they are bacteriostatic or bactericidal |
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Definition
aminoglycosides cidal
tetracyclines static
macrolides static
lincosamides static
chloramphenicol static
oxazolidinones ?
sulfonamides static
trimethoprim static
quinolones cidal
rifampin cidal
polymixins cidal
nitroimidazoles ? |
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Term
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Definition
| bind exit tunnel of large subunit |
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Term
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Definition
| methylation of 23S rRNA (or mutation) |
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Term
| methylation of 23S rRNA confers resistance to (2) |
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Definition
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Term
| lincosamide mechanism: it binds _ blocking |
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Definition
binds large subunit
blocks tRNA binding & exit tunnel |
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Term
| clindomycin is an example of |
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Definition
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Term
| an example of oxazolidinones |
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Definition
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