Term
| Synergistic drug interaction |
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Definition
| Occurs when two drugs result in an increased effect more than just the addition of both |
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Term
| Pharmacodynamic drug interaction |
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Definition
| Drugs that interact at a common receptor site or that have additive or inhibitory effectors due to actions at different sites in an organ |
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Term
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Definition
| Whenever one drug affects the pharmacokinetics, pharmacodynamics, efficacy, or toxicity of another drug |
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Term
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Definition
| A person who metabolizes a certain drug–the rate of which is related to the metabolizing cytochrome P-450 enzyme–slower than others |
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Term
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Definition
| The drug affected by the drug interaction |
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Term
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Definition
| The drug causing the drug interaction |
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Term
| Antagonistic drug interaction |
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Definition
| Occurs when one drug lessens the effects of another |
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Term
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Definition
| Refers to a set of enzymes that metabolize numerous substrates via oxidation (Phase I reaction) |
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Term
| Pharmacokinetic drug interaction |
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Definition
| Occurs when one drug alters the rate or extent of absorption, distribution, metabolism, or excretion of another drug; the result may be and increase or decrease in concentration of drug at the site of action |
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Term
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Definition
| An inducer increases the metabolism of a substrate resulting in a decreased level or effect of the substrate |
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Term
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Definition
| Study of genetic cause of individual variations in drug response |
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Term
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Definition
| …more broadly involves genome-wide analysis of the genetic determinant of drug efficacy and toxicity; includes the use of genomic technologies |
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Term
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Definition
| A variation in DNA sequence present in <1% of the population |
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Term
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Definition
| A variation in DNA sequence present in ≥ 1% of the population |
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Term
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Definition
| A single nucleotide polymorphism |
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Term
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Definition
| Occurs when a nucleotide change occurs yet the resultant amino acid is unchanged |
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Term
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Definition
| Occurs when a nucleotide change occurs and there is a resultant amino acid change which can affect to efficacy and/or toxicity of a drug |
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Term
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Definition
| One of the variant forma of a gene at a particular location on a chromosome |
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Term
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Definition
| The two alleles that any individual has |
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Term
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Definition
| The clinical presentation of an individual with a particular genotype |
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