Term
| COMT Substrate and reaction |
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Definition
| OH on catechol (benzene with two OH) --> OH gets turned into O-CH3 |
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Term
| MAO substrate and reaction |
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Definition
| Primary amine --> aldehyde |
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Term
| Aldehyde dehydrognease substrate and reaction |
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Definition
| Aldehyde --> carboxylic acid |
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Term
| Reaction of catecholamine + light |
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Definition
| Oh on catechol (benzene with two OH) become carbonyl (double bond O) |
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Term
| alpha 1 agonists indication |
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Definition
| shock, hypotension, nasal decongestant |
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Term
| alpha 2 antagonist indication |
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Definition
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|
Term
| alpha 2 agonist indication |
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Definition
| antihypertensives, glaucoma, analgesia, sedatives |
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Term
| alpha 1 antagonist indication |
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Definition
|
|
Term
| Beta 1 antagonist indication |
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Definition
| antihypertensives, antiarrhythmics |
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|
Term
| beta 2 antagonists indication |
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Definition
|
|
Term
| Beta 1 agonist indication |
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Definition
|
|
Term
| beta 2 agonists indication |
|
Definition
| bronchodilators, glaucoma |
|
|
Term
| beta 3 agonists indication |
|
Definition
| weight loss (investigational) |
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|
Term
| beta 3 antagoists indication |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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|
Term
| tetrahydrozoline receptor |
|
Definition
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|
Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
| phenylpropanoloamine receptor |
|
Definition
| indirect adrenergic agonist |
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Term
|
Definition
| indirect adrenergic agonist |
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Term
|
Definition
| indirect adrenergic agonist |
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|
Term
| amphetamine + dextramphetamine receptor |
|
Definition
| indirect adrenergic agonist |
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Term
|
Definition
| indirect adrenergic agonist |
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Term
|
Definition
| indirect adrenergic agonist |
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|
Term
| dexmethyphenidate receptor |
|
Definition
| indirect adrenergic agonist |
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|
Term
| phenoxybenzamine receptor |
|
Definition
| non-selective alpha antagonist |
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|
Term
| tolazoline antagonist receptor |
|
Definition
| non-selective alpha antagonist |
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|
Term
|
Definition
| non-selective alpha antagonist |
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|
Term
|
Definition
| selective alpha 1 antagonist |
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|
Term
|
Definition
| selective alpha 1 antagonist |
|
|
Term
|
Definition
| selective alpha 2 antagonist |
|
|
Term
|
Definition
| non-selective beta antagonist |
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|
Term
|
Definition
| non-selective beta antagonist |
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|
Term
|
Definition
| non-selective beta antagonist |
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|
Term
|
Definition
| non-selective beta antagonist |
|
|
Term
|
Definition
| non-selective beta antagonist |
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|
Term
|
Definition
| non-selective beta antagonist |
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|
Term
|
Definition
| selective beta 2 antagonist |
|
|
Term
|
Definition
| selective beta 2 antagonist |
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|
Term
|
Definition
| selective beta 2 antagonist |
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|
Term
|
Definition
| selective beta 2 antagonist |
|
|
Term
|
Definition
| selective beta 2 antagonist |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
[image]
Effect of Changing R1 is? |
|
Definition
Increasing size lowers alpha 1 activity. Bigger than butyl blocks alpha 1 comletely
Big and bulky groups make beta 2 selective. Very long groups make it long acting (salmeterol) |
|
|
Term
[image]
Effect of changing R2? |
|
Definition
Small R2 (methyl or ethyl) allows for alpha 1 selectivity.
For Beta selectivity, R2 MUST be H |
|
|
Term
|
Definition
3' Hydroxy = alpha selectivity
MUST BE 3' hydroxy for alpha
3', 5' hydroxy = beta 2 selectivity
3', 4' methylhydroxy = beta |
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