Term
| Second most common primary malignant bone tumor |
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Definition
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Term
| Age predilection of osteosarcoma |
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Definition
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Term
| Osteosarcoma most common presenting complaint is |
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Definition
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Term
| Most common sites of osteosarcoma |
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Definition
| distal femur, proximal tibia, proximal humerus |
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Term
| Lab finding of osteosarcoma |
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Definition
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Term
| 3 radiologic features of osteosarcoma |
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Definition
| 50% sclerotic; 25% lytic; 25% mixed |
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Term
| Osteosarcoma location on a long bone is primarily |
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Definition
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Term
| Ostosarcoma will have a ___ periosteal response |
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Definition
| sunburst/sunray (hair on end appearance) |
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Term
| Bone left away response with osteosarcoma will appear as |
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Definition
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Term
| Osteosarcoma will have cortical disruption with |
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Definition
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Term
| Clinically male 2:1; age 10-25 years; pain and swellingl may mimic infection (slight fever, leukocytosis, elevated ESR) |
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Definition
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Term
| 4th most common primary malignant tumor |
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Definition
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Term
| Ewings sarcoma is a round cell tumor in the ___ |
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Definition
| diaphysis but may descend to the metaphysic |
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Term
| Ewing's sarcoma will have a ___ zone of transition |
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Definition
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Term
| Ewing's sarcoma periosteal reaction will show |
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Definition
laminated or onion skin
(osteosarcoma will have sunburst or speculated) |
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Term
| Clinically: Age 40-60; M:F 2:1; pain and swelling is the presenting complaint |
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Definition
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Term
| 3rd most common primary malignant bone tumor |
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Definition
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Term
| Chondrosarcoma radiologically will have ___ radiolucencies with ill defined margins |
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Definition
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Term
| Chrondrosarcoma will have a predilection for the |
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Definition
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Term
| Chondrosarcoma will show endosteal ___ |
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Definition
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Term
| ___ calcification is seen on 2/3 of chondrosarcoma |
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Definition
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Term
| 1/3 of chondrosarcoma will show |
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Definition
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Term
| Chondrosarcoma will have a ____ periosteal response |
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Definition
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Term
| Common site of chondrosarcoma |
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Definition
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Term
| Older patient with metaphyseal lesion |
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Definition
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Term
| Younger patient with metaphyseal lesion |
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Definition
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Term
| Clinical ages 4-83 years; pain and swelling; long duration of symptoms |
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Definition
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Term
| Primary malignant bone tumor that is rare |
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Definition
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Term
| Fibrosarcoma is a ___ medullary lesion |
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Definition
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Term
| Fibrosarcoma is a ___ lesion |
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Definition
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Term
| Fibrosarcoma is __ placed |
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Definition
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Term
| Largest soft tissue mass of all primary malignant tumors |
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Definition
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Term
| Fibrosarcoma is seen in the |
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Definition
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Term
| Age: 50-70; M:F 2:1; Pain is the cardinal symptom relieved by rest and aggravated by weight bearing |
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Definition
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Term
| Most common site of multiple myeloma is |
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Definition
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Term
| The most common primary malignant bone tumor |
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Definition
| multiple myeloma (plasma cell proliferation) |
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Term
| Other sites of multiple myeloma other than the spine are |
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Definition
| pelvis, skull, ribs, scapula, long bones |
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Term
| In the labs 40% of multiple myeloma patients will show |
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Definition
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Term
| ____ is helpful in the diagnosis of multiple myeloma |
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Definition
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Term
| One early sign of multiple myeloma |
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Definition
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Term
| Hallmark of multiple myeloma |
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Definition
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Term
| Multiple myeloma will show vertebra ___ or wrinkled vertebrae |
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Definition
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Term
| ___ lesions tend to be the most uniform |
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Definition
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Term
| Multiple myeloma will show the pedicle sign that |
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Definition
| the pedicles remain intact |
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Term
| In multiple myeloma the punched out lesions may __ |
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Definition
| coalesce and become one large lesion |
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Term
| Localized form of plasma cell proliferation |
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Definition
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Term
| Most common sites of plasmacytoma |
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Definition
| mandible, ilium, vertebrae, ribs, proximal femur, scapula |
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Term
| 70% of plasmacytomas develop into |
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Definition
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Term
| Geographic lesion, soap bubble appearance, highly expansile appearance, with pain, older patients, holes with punched out lesion |
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Definition
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Term
| __ is the most life threatening complication of any malignancy |
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Definition
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Term
| Most common malignant tumors of the skeleton are |
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Definition
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Term
| 80% of metastasis comes from these 4 areas |
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Definition
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Term
| Clinical features: Age >40; patient experiences weigh loss, cachexia, bone pain (often worse at night) |
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Definition
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Term
| Labs seen with metastasis |
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Definition
alkaline phosphatase elevation
Acid phosphatase elevation in prostatic carcinoma |
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Term
| 3 metastatic pathways of spread |
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Definition
hematogenous
lymphogenous
direct invasion via adjacent organ |
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Term
| Most common form of metastatic spread |
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Definition
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Term
| Most common sites of metastatic spread |
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Definition
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Term
| Other sites of metastatic spread |
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Definition
| axial skeleton, ilium, pubic rami |
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Term
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Definition
| axial skeleton (spine, humerus, femur) |
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Term
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Definition
| below the elbow and knees |
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Term
| Fundamental sign of metastasis |
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Definition
| alteration in bone density architecture: more radio opaque or radiolucent |
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Term
| 75% of metastatic spread is |
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Definition
| osteolytic- moth eaten bone destruction |
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Term
| 15% of metastatic spread is |
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Definition
| Osteoblastic-increased bone density |
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Term
| 10% of metastatic spread is |
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Definition
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Term
| Blown out lesions of metastatic spread are seen in |
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Definition
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Term
| Favorite sites on the spine of metastatic spread |
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Definition
| vertebral bodies, pedicles |
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Term
| one pedicle is destroyed by metastasis and the other will not be as bright white |
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Definition
| one eyed pedicle sign in metastasis |
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Term
| one pedicle is destroyed by metastasis and the other will be a brighter white |
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Definition
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Term
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Definition
| both pedicles are destroyed by metastasis |
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Term
| Vertebra plana seen with metastasis |
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Definition
| vertebral body is flattened due to metastasis |
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Term
| Osteoblastic metastasis will be __ on bone scan |
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Definition
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Term
| Multiple myeloma bone scan will be __ |
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Definition
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Term
| Most common etiology for osseous osteolytic metastasis for females |
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Definition
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Term
| Most common etiology for osteolytic metastasis for males |
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Definition
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Term
| Most common etiology for osteoblastic metastasis for females |
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Definition
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Term
| Most common osteoblastic metastasis for males |
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Definition
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Term
| Young patients most common etiology for osteolytic metastasis is |
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Definition
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Term
| Young patients most common etiology for osteoblastic metastasis is |
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Definition
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Term
| Osteoblastic metastasis to the spine in ages >50 will show up as |
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Definition
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Term
| Osteoblastic metastasis to the spine in younger ages (20-30) will show up as |
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Definition
| ivory vertebrae (hodgekins lymphoma) |
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Term
| Ivory vertebrae viewed as expansile in ages greater than 50 will be |
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Definition
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Term
| The most common primary malignant bone tumors in order are |
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Definition
multiple myeloma
osteosarcoma
chondrosarcoma
Ewings |
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Term
| The most common malignancy is |
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Definition
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Term
| Pathological compression fractures are |
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Definition
| uniformly compressed vertebra |
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Term
| Non pathological compression fx are |
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Definition
| wedge like, posterior portion of the vertebra not compressed |
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