Term
| 1. _____ are malignant neoplasms of cells native to lymphoid tissues predominantly nodes, and most often cells of B-cell origin. |
|
Definition
|
|
Term
| 2. The 2 types of malignant lymphomas are _____and _____. |
|
Definition
| HODGKIN’S LYMPHOMA AND NON-HODGKINS LYMPHOMA |
|
|
Term
| 3. When a patient has lymphoma, there are NO SYMPTOMS of these 6 conditions. |
|
Definition
| 1) LYMPHADENOPATHY, 2) ELEVATED WBC COUNT, 3) INFECTION, 4) WEIGHT LOSS, 5) FEVER, 6) MALAISE |
|
|
Term
| 4. What is the most common cell affected by malignant lymphomas? |
|
Definition
|
|
Term
| 5. 5 features of non-hodgkin’s lymphoma. |
|
Definition
| 1) LYMPADENOPATHY, 2) NON-TENDER NODAL INVOLVEMENT, 3) POTENTIAL METASTASIS BETWEEN NODES, 4) DISSEMINATION TO SPLEEN LIVER AND BONE MARROW, 5) POTENTIAL TO SPILL INTO BLOOD |
|
|
Term
| 6. The classification of non-hodgkins lymphomas consist of _____ at the time of diagnosis. |
|
Definition
|
|
Term
| 7. Non-hodgkins lymphoma cancers can be _____ or _____. |
|
Definition
| SLOW GROWING OR AGGRESSIVE |
|
|
Term
| 8. 4 different types of adult non-hodgkins lymphomas. |
|
Definition
| 1) FOLLICULAR LYMPHOMAS, 2) LARGE B-CELL LYMPHOMAS, 3) SMALL LYMPHOCYTIC LYMPHOMA, 4) CHRONIC LYMPHOCYTIC LEUKEMIA |
|
|
Term
| 9. _____ is the most common slow growing lymphoma of adult non-hodgkins lymphoma is exclusively of B-cell origin, that is very difficult to cure. |
|
Definition
|
|
Term
| 10. _____ is a slow growing lymphoma of adult non-hodgkins lymphoma that consists of small compact, unstimulated lymphocytes that spills into blood causing a slow indolent course. |
|
Definition
| SMALL LYMPHOCYTIC LYMPHOMA |
|
|
Term
| 11. _____ is an aggressive rapidly fatal type of lymphoma associated with adult non-hodgkins lymphoma that spreads to the bone, brain and GI tract. |
|
Definition
|
|
Term
| 12. 2 different types of childhood lymphomas. |
|
Definition
| 1) ACUTE LYMPHOBLASTIC LYMPHOMA, 2) BURKITT’S LYMPHOMA |
|
|
Term
| 13. _____ is the most common childhood lymphoma that causes a mediastinal mass with an accumulation of macrophages causing a “starry sky” appearance. |
|
Definition
|
|
Term
| 14. Lymphoblastic lymphomas are _____ and _____. |
|
Definition
| AGGRESSIVE AND RAPIDLY PROGRESSIVE |
|
|
Term
| 15. These are the 2 different types of burkitt’s lymphoma. |
|
Definition
| 1) AFRICAN FORM, 2) SPORADIC FORM |
|
|
Term
| 16. 4 characteristics of the African form of burkitt’s lymphoma. |
|
Definition
| 1) RESPONDS WELL TO CHEMI, 2) MAXILLA/MANDIBLE PRESENTATION, 3) STARRY SKY HISTOLOGY, 4) ASSOCIATED WITH PRIOR EBV INFECTION |
|
|
Term
| 17. _____ is a childhood lymphoma associated with starry sky morphology of macrophages. |
|
Definition
|
|
Term
| 18. This type of burkitt’s lymphoma has no association with the EBV. |
|
Definition
|
|
Term
| 19. _____ is a neoplasm of lymphoid tissue arising in a single node or chain of nodes. |
|
Definition
|
|
Term
| 20. _____ is the most common malignancy in young adults. |
|
Definition
|
|
Term
| 21. Survivors of Hodgkin’s lymphoma have an increased risk of developing _____. |
|
Definition
|
|
Term
| 22. 4 characteristics that made hodgkins lymphoma different from non-hodgkins. |
|
Definition
| 1) PRESENCE OF REED STERNBERG CELL, 2) PRESENCE OF NON-NEOPLASTIC INFLAMMATORY CELLS, 3) NON-SPECIFIC SYMPTOMOLOGY, 4) AFFECTS YOUNG ADULTS |
|
|
Term
| 23. _____ is a large cancer cell of unknown origin present in hodgkin’s lymphoma that has a binucleate nucleus. |
|
Definition
|
|
Term
| 24. Hodgkin’s lymphoma spreads in a very predictable pattern to these 4 places. |
|
Definition
| 1) LYMPH NODES, 2) SPLEEN, 3) LIVER, 4) BONE MARROW |
|
|
Term
| 25. This stage of hodgkin’s lymphoma is when there is involvement of a single lymph node region. |
|
Definition
|
|
Term
| 26. This stage of hodgkin’s lymphoma is when 2 or more nodal regions are affected on the same side of the diaphragm. |
|
Definition
|
|
Term
| 27. This stage of hodgkins lymphoma is when there is involvement of nodes on both sides of the diaphragm. |
|
Definition
|
|
Term
| 28. This stage of hodgkins lymphoma is when there is diffuse, disseminated nodal involvement. |
|
Definition
|
|
Term
| 29. _____ is a primary bone neoplasm of older individuals (>60) causing excess secretion of antibodies from malignant plasma cells. |
|
Definition
|
|
Term
| 30. _____ is a protein present in the Ig light chain of antibodies in people affected with multiple myeloma. |
|
Definition
|
|
Term
| 31. 2 dangers of having excessive production of bence-jones proteins. |
|
Definition
| 1) RENAL DYSFUNCTION, 2) AMYLOIDOSIS |
|
|
Term
| 32. _____ is used to diagnose the presence of bence-jones proteins. |
|
Definition
|
|
Term
| 33. Multiple myeloma is a major cause of _____. |
|
Definition
| PRIMARY AMYLOIDOSIS (MYELOMA KIDNEY) |
|
|
Term
| 34. This is the most commonly secreted antibody in multiple myeloma. |
|
Definition
|
|
Term
| 35. The excessive secretion of IgG antibodies in multiple myeloma leads to a _____ spike. |
|
Definition
|
|
Term
| 36. These 3 areas of the skeleton are affected by multiple myeloma. |
|
Definition
| 1) VETEBRAL COLUMN, 2) SKULL, 3) LONG BONES |
|
|
Term
| 37. When the malignant plasma cells are secreting antibodies and bence-jones proteins, they are also secreting _____ which causes plasma cell proliferation and osteoclast activation. |
|
Definition
| IL-6 (OSTEOCLAST ACTIVATING FACTOR {OAF} ) |
|
|
Term
| 38. Multiple myeloma causes _____ lesions in the cranium due to activating osteoclast activity. |
|
Definition
| PUNCHED-OUT LYTIC LESIONS |
|
|
Term
| 39. 5 clinical presentations of patients with multiple myeloma. |
|
Definition
| 1) HYPERCALCEMIA, 2) SYSTEMIC INFECTION, 3) RENAL DISEASE, 4) PATHOLOGIC FRACTURES, 5) BONE PAIN |
|
|
