Term
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Definition
| what are the two types of lymph (structurally) |
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Term
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Definition
| lymphoid tissue that is organized into discreet structures or organs (lymph node, spleen, thymus, tonsil) |
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Term
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Definition
| lymph tissue located throughout the body, associated with mucous membranes |
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Term
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Definition
| both dense and diffuse lymph tissue contain large numbers of ___ |
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Term
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Definition
| lymph tissue is common in in respiratory and digestive tracts as _____ |
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Term
| children, it progressivly atrophies in adults |
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Definition
| do adults or children have more MALT? |
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Term
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Definition
| lymphoid tissue where b & t cells acquire surface receptors |
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Term
in primary lymphoid tissue
b: bone marrow
t: thymus |
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Definition
| where do b cells acquire surface receptors? t cells? |
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Term
| secondary lymphoid tissue |
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Definition
| where mature b and t cells migrate to |
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Term
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Definition
| malignant tumors of the immune system that involve solid organs |
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Term
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Definition
| malignant tumors of the immune system that involve blood |
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Term
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Definition
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Term
| cells and large molecules |
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Definition
| lymph vessels provide a route which allows ____ and ____ in ECS to re-enter the blood stream |
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Term
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Definition
| lymph vessels concentrate ___ for elimination in lymph nodes |
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Term
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Definition
| single layer lymph endothelial cells hightly active in ______ while blood vessel endothelial cells are not |
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Term
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Definition
| encapsulated aggregates of lymphocytes and lymphoid tissue distributed throughout body |
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Term
| in chains or clusters around vessels of lymphatic origin (submandibular, cervical, axillary, femoral, popliteal, hilar) |
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Definition
| where are lymph nodes found? |
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Term
1) non-specific filtering of particulate matter and microbes from lymph
2) interaction of circulating lymphocytes with Ag in lymph
3) aggregation, activation, and proliferation of b cells with subsequent Ab pdxn (clonal expansion)
4) aggregation & proliferation of t cells & induction of cytotoxic immunity |
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Definition
| what are the 4 functions of lymph nodes? |
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Term
1) lymphoid cell
2) immune accessory cell [follicular dendritic cells & tingible body macrophages]
3) stromal cells |
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Definition
| list the types of cells found in lymph nodes |
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Term
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Definition
| lymphocytes of all types, derived from bone marrow, enter lymph node via blood stream |
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Term
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Definition
| antigen presenting cells (macrophage, t & b cells) originate in bone marrow |
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Term
| follicular dendritic cells |
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Definition
| macrophage at periphery of germinal centers, antigen presenting cells with extensive cytoplasmic processes |
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Term
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Definition
| macrophage primarily found in germinal centers, possess many phagocytic vessicles |
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Term
| who knows, but morrow pointed out that follicular can become tingible |
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Definition
| can tingible body macophages become follicular dendritic cells? |
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Term
| tingible = stainable due to the debris in their body |
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Definition
| why are tingible body macrophages named so? |
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Term
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Definition
| fibroblasts and reticular cells (fibroblast like cells with phagocytic capability) |
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Term
| stromal cells & extracellular products (collagen, reticular fibers) |
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Definition
| forms the CT skeleton of lymph nodes |
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Term
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Definition
| what kind of connective tissue forms the outer fibrous capsule of lymph nodes? |
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Term
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Definition
| which is more cellular in a lymph node: the cortex or the medulla? |
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Term
| b cells, t cells, plasma cells |
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Definition
| what types of cells are found within the outer cellular cortex of lymph nodes? |
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Term
OUTER cortex, INNER medulla
note: CORE-tex is not the right spelling, CORE-tex is not at the core, but the MEDulla is in the middle. |
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Definition
| which is inner, and outer: cortex, medulla |
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Term
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Definition
| extensions of cortical tissue into medulla in lymph nodes |
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Term
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Definition
| interspersed throughout cortex and medulla are thin, collagenous ____ |
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Term
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Definition
| blood vessels enter and leave lymph nodes at the ____ |
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Term
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Definition
| b & t cells leave the blood stream and enter lymph nodes via _________ |
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Term
| complementary adhesion molecules (addressins) |
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Definition
| facilitates diapedesis of b & t cells from blood to lymph node |
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Term
| they are present on both endothelial cells and lymphocytes in lymph nodes, they help with b & t cell diapedesis (like projections on a rock climbing wall, they help with recognition and crawling) |
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Definition
| where are addressins found, what do they do? |
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Term
| specialized post capillary venules (high endothelial venules) |
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Definition
| where does diapedesis occur(what vessels) for b and t cells? |
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Term
| cuboidal to columnar (taller stuff) |
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Definition
| what kind of "-thelia" lines high endothelial venules? |
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Term
| deep inner cortex of node at corticomedullary junction (paracortical zone) |
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Definition
| where does diapedesis from the postcapillary venules occur in the lymph node structure? |
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Term
| cortical/subcapsular sinus |
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Definition
| space beneath the capsule of lymph nodes where numerous AFFERENT lymph vessels drain into |
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Term
| continuous adjacent to capsule, discontinuous adjacent to parenchyma |
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Definition
| endothelium on the ____ side of a lymph node adjacent to the capsule is continuous to prevent leakage, but discontinuous on the side to ______ |
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Term
| lymphatic sinuses are not open spaces, they are filled with reticular fibers and macrophage processes |
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Definition
| how are lymphatic sinus different from blood sinuses? |
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Term
| cortical sinuses, trabecular sinuses, or peritrabecular sinuses (all are the same thing) |
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Definition
| what are lymphatic sinuses in the outer cortex called? |
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Term
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Definition
| broad lymphatic channels in inner less cellular medulla |
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Term
| contain lymphocytes, plasma cells, macrophages. they converge on the hilus |
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Definition
| what do medullary sinuses contain, and where do they converge? |
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Term
| a large SINGLE efferent lymph vessel |
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Definition
| how does lymph drain from the hilus of a lymph node? |
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Term
many afferent which drain into the subcapsular sinus.
a single efferent vessel that drains from the hilus |
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Definition
| describe how many afferent vs efferent vessels are in a lymph node, and their location |
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Term
| thoracic duct OR R lymphatic duct |
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Definition
| how does lymph return to the bloodstream(where) |
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Term
| lymphatic drainage to regional lymph nodes |
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Definition
| ___ is important in metastasis of tumor cells |
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Term
| in the cortex of lymph nodes |
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Definition
| where are densely packed, highly cellular lymphoid follicles? |
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Term
| lymphatic nodules, primary follicles |
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Definition
| another name for lymphoid follicles |
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Term
| pale, less dense, germinal centers - means lymph node is responding to antigen |
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Definition
| what are secondary follicles, and what do they mean? |
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Term
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Definition
| lymphocytes respond to antigen by increasing antibody production via ____ ___ |
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Term
| lymph node enlargment "swollen glands" |
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Definition
| proliferation of lymphocytes causes what? |
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Term
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Definition
| darker staining rim surrounding germinal centers (the region of antibody production) in a lymph node |
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Term
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Definition
| sites of b-cell proliferation(secondary hemopoiesis) also contains lymphoblasts, macrophages, and immature b& t cells |
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