Term
| What percentage of lung cancer is small cell vs. non-small cell? |
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Definition
| 20% small cell; 80% non small cell |
|
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Term
| most common type of non-small cell carcinoma |
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Definition
|
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Term
| strongest association with smoking |
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Definition
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Term
| p53 mutations are uncommon in __ |
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Definition
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Term
| benzopyrene metabolites causes G->T mutation in what gene |
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Definition
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Term
| loss of Rb is due to inactivation of ___ |
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Definition
|
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Term
| genes found on 3p chromosome |
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Definition
| FHIT, RasF1A, beta-catenin, SEMA3B |
|
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Term
| mutations assc'd with non-small cell only |
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Definition
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Term
| mutations assc'd with small cell carcinoma only |
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Definition
|
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Term
| common mutations in exons 19, 20, 21; protein? |
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Definition
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Term
| tyrosine kinase inhibitors (2) |
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Definition
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Term
| tumor growth into pleura cause ... |
|
Definition
| unilateral pleural effusion |
|
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Term
| pt presents with swelling of face, arms, and neck and shows dilated upper body veins; dx? |
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Definition
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Term
| tumor impinges on ___ and causes hoarseness |
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Definition
|
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Term
|
Definition
| ptosis, miosis, anhydrosis, enopthalmos |
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Term
|
Definition
| tumor growth in C8, T1, and T2 -> pain from shoulder to ulna, Horner's, and destruction of ribs 1 and 2 |
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Term
| excess ADH, ACTH; what cancer? |
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Definition
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Term
| hypercalcemia, excess prostaglandins; what cancer? |
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Definition
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Term
| flushing, sweating, wheezing; what cancer? |
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Definition
|
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Term
| neuromuscular paraneoplastic syndrome |
|
Definition
| ataxia, vertigo, proximal m. weakness (Lambert-Eaton), peripheral neuropathy |
|
|
Term
| pathology of Lambert Eaton's syndrome |
|
Definition
| autoantibodies against Ca channels in neurons |
|
|
Term
| hypertrophic pulmonary osteoarthropathy |
|
Definition
| joint swelling, clubbing, edema, subperiosteal new bone |
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Term
| metastasis sites in order of first to last |
|
Definition
| lymph node, other lung, brain, adrenals, liver, bone marrow, lower GI |
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Term
5y survival rate without surgery = __%
5y survival rate with surgery = __% |
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Definition
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Term
1. hilar mass with cavitations; dx?
2. peripheral mass without necrosis/cavitations; dx?
3. peripheral mass with necrosis |
|
Definition
1. squamous cell carcinoma
2. adenocarcinoma
3. large cell carcinoma |
|
|
Term
| 1. cytokeratin5/6+, cytokeratin7-, TTF1-; dx? 2. cytokeratin7+, TTF1+; dx? |
|
Definition
| 1. squamous cell carcinoma 2. adenocarcinoma |
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Term
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Definition
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|
Term
| 5 gross presentations of adenocarcinoma |
|
Definition
| pleural puckering, hilar, lobar, visceral pleura, scarring |
|
|
Term
| 2 histological presentations of BAC |
|
Definition
1. non-mucinous: Clara cells, type II epithelial cells; solitary
2. mucinous: mucus cells, mucicarmine+; diffuse |
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Term
| tx for adenocarcinoma in Japanese females |
|
Definition
| tyrosine kinase inhibitor |
|
|
Term
| adenocarcinoma: signs of good vs. bad prognosis |
|
Definition
| good: Bcl-2, ground glass; bad: papillary histology |
|
|
Term
| neuroendocrine markers = ?; what cancers are they found in? |
|
Definition
| synaptophysin, chromogranin, CD56; small cell carcinoma, large cell neuroendocrine carcinoma |
|
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Term
1. salt and pepper chromatin; nuclear molding, ill-defined borders of cells; dx?
2. salt and pepper chromatin; no nuclear changes, uniform and polygonal cells; dx? |
|
Definition
1. small cell carcinoma
2. carcinoid tumor |
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Term
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Definition
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Term
|
Definition
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Term
| tx for small cell carcinoma |
|
Definition
| radiation, chemotherapy; NO SURGERY |
|
|
Term
| typical vs. atypical carcinoid tumor |
|
Definition
| typical: <2/HPF, bronchial location, no necrosis, better prognosis atypical: 2-10/HPF, peripheral location, necrosis, worse prognosis |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| >60yo male coal miner presents with dyspnea, wheezing, coughing, and chest pain; dx? |
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Definition
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|
Term
| asbestos types? most common? |
|
Definition
| crocodolite (most common), amosite, chrysolite |
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|
Term
| CXR: calcified plaque on pleura or diaphragm indicates __ |
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Definition
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Term
|
Definition
| asbestos exposure--work up for mesothelioma |
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Term
|
Definition
|
|
Term
| metastasis to lungs usually target [peripheral/hilar] sites |
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Definition
|
|
Term
| good prognostic signs for mesothelioma |
|
Definition
| female<50yo, epithelioid histology, no chest pain |
|
|
Term
1. most aggressive cancer
2. metastasizes early and widely |
|
Definition
1. small cell carcinoma
2. adenocarcinoma |
|
|
Term
| mutations assc'd with non small cell carcinoma only |
|
Definition
|
|
Term
| Her-2, cox2, met mutations; cancer? |
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Definition
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