Term
| Normal lithium concentrations |
|
Definition
| nausea, vomiting, anorexia, abdominal pain, fine hand tremor, mild polyuria/polydipsia, muscle weakness |
|
|
Term
| moderate toxicity (1.5-2.5 mEq/L) |
|
Definition
| course tremor/twitching, GI upset, vertigo, confusion, sedation/lethargy, hyperreflexia |
|
|
Term
|
Definition
| seizures --> stupor--> coma --> CV collapse --> death |
|
|
Term
|
Definition
| at least 7 days (3-5 during acute phase) |
|
|
Term
| therapeutic effect of lithium |
|
Definition
| 14-21 days. doses can be adjusted earlier |
|
|
Term
|
Definition
| every 4-7 days, then q 1-3 months |
|
|
Term
| increases lithium concentration |
|
Definition
| diuretics, NSAIDs, ACE inhibitors, TCAs, alcohol, volume depletion, low sodium diet, hypothyroidism |
|
|
Term
| decreases lithium concentration |
|
Definition
| aminophylline, pregnancy, strenuous exercise, hot climate, crash dieting |
|
|
