Term
| exogenous pathway funciton |
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Definition
| transports dietary triglyceridesf orm intestines to various tisuses |
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Term
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Definition
| formed in inestines absorbed via lympahtic system and put into circulation. Lipoprotein lipase in capillaries releases triglycerides to msuce ,adipose and HDL, and the chylomicron remnant retaken up by liver |
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Term
| chylimciron pathway deficiencies |
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Definition
defieicny of LPL can be genetic results in chylmicrons remainign in b lodo and triglyeridemia.
also hylomicron remnant receptor deficiencies woudl result in remainder of ahterogenic chylomicoron remnants in blood |
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Term
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Definition
VLDL is sytnehsized in liver, from lipids derived form diet or sytnehsizedi n liver, as well as FFa from adipose tissues.
VLDL is acted upon by LPL and VLDL now is IDL.
IDL can now be taken up via ApoE receptor on liver, or be acted upon by hepatic lipase to form LDL.
LDL is uptaken via ApoB to peripheral tissues, or taken up via apoB receptor to liver |
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Term
| repsonse of cell to incresed choelsterol delistery |
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Definition
| downdgrading of LDL receptor activity |
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Term
| defects in Endogenous pathway |
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Definition
defective ldl receptor resulting in accumualtion of LDL, IDL, and VLDL.
Alsom tuations in ApoB result in defectie LDL binding. |
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Term
| endogenous pathway defects lead to |
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Definition
| familial hyperhcoelsterolemia. |
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Term
| Reverse choelsterol transprot |
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Definition
Nascent HDL comes otu of liver and itnesttines. They accept constituents from chylomicrons and VLDL forming hdl33, as well as from arteria lwal lamcrohpages , formign hdl2.
Then they transfer cholesterol over to VLDL/IDL/LDL in exchange for TG, via CETP. then they are delivered to the liver. |
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Term
| HDLC high levels rpotect you from |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| high chylomicronsand VLDL |
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Term
| sever chylcomicronemia diet adjustement |
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Definition
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Term
| aptietns with truncal o besity, metabolic s ydnrome ,t,ype Ii diab etes diet |
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Definition
| aim primarily at weig ht reduction |
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Term
| subjectswith high LDL with eveyrthign else nromal |
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Definition
| low saturated fats, lwo trans fatty acidand low choelster ol |
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Term
| Niemana pick c1 protein fucntino |
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Definition
| intestianl mucosal suface transporter to choelsterol and plant sterols |
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Term
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Definition
| Kick plant sterols back into the intestinal lumen |
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Term
| effect of dietary choelsterol in normal people |
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Definition
| little effect duet o feedback inhibition to liver, and reduced absorptionw . defect in feedback inhibitionr (i.e. familial hyperhcoelsterolemia) could alter the response to dietary cholesterol |
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Term
| effect of fatty acid on serum cholesterol |
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Definition
saturated fatty acids, raise seru mchoelsterol. polyunsaturated hae less of an effect.
polyunsaturated fatty acids lwoer serum choelsterol,
Monounstaurated fatty acids neutral or are ablet o lweor choelsterol |
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Term
| trans fatty acids how prodcued and effects |
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Definition
| hydrogenation of polyunsaturated fatty acids- unfaboralve effect for CAD |
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Term
| Diets rich in carbohydrates effect on lab valus |
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Definition
| they are low in fats so they stimualte plasma vLDL and icnrased hepatic secretion with reduced clearnace of vldl. also simtulating insulin -Leads to icnreased TG and VLDL syntehsis adn aggravates metabolicsyndrome |
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Term
| dietary fibers effect on choelsterol |
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Definition
| lowseurm choelstero lby ability to icnrease feca lexcretion of bile salts and choelsterol |
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Term
| Antioxidants effect on choelsterol |
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Definition
| because liporporetin oxidation is improatnt in atherogensis, antoioxidants haelp reduce the risk factos of CAD. |
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Term
| msot effect diet modication to preent aderse cardiovascular eents |
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Definition
| reduce sturated fat adn trans fatty acid intake. |
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Term
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Definition
smokign HTN, low hDL cholesterol, family history of premature CHD, and AGE
diabets is coronary heart didsease equivelant |
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Term
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Definition
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Term
| theraputic target for CHD |
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Definition
| Non-hDl cholesterol (ratherh tan just LDl cholesterol) |
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Term
| LDL cholesetrol calcuatilion |
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Definition
| total choelsterol - HDLC - TG/5 |
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Term
| bile chielating resisn name and fucntion |
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Definition
| choelstyramine ,disrupt eneterohepatic circulation of bile salts, leading to increased hepatic produciotn of bile acids.. |
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Term
| biel chelating resins side effects |
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Definition
| comepsnatory increae in hepatic choelsterol and vldl synthesis. constipation adn imapried absoprtion of fat solbule vitamins and drugs |
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Term
| inhibitors of choelstero lstnehsis names |
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Definition
| platn sterols and ezemetibie |
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Term
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Definition
| blocks npc1 expression, leading to decreased choelstero labsoprtion. |
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Term
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Definition
| inhibits TG hydrolsosis na d decerased edelviery of FAF to liver, decreasing VDLDL and LDL. |
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Term
| nictonic acid usfeul in aptients with |
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Definition
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Term
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Definition
| inbhition of hmg-coa reductase- rate limitign step in choelsteorl snth. Upregulates hatpic LDL receptor. |
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Term
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Definition
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Term
| fibic acid derivatives fucntion |
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Definition
| increase LPL activity, decrease vldl sytnehsis ,adn increase LDL catabolism. - use in TG subjects. |
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Term
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Definition
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