Term
| 1. _____ is a neoplastic disorder of uncontrolled proliferation of hematopoietic stem cells characterized by replacement of bone marrow with malignant cells. |
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Definition
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Term
| 2. Leukemic cells spill into blood and may even infiltrate _____ and even _____. |
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Definition
| VISCERAL ORGANS AND LYMPH NODES |
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Term
| 3. _____ cell types give rise to granulocytes. |
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Definition
| MYELOID CELLS (MYELOGINOUS) |
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Term
| 4. _____ cell types give rise to lymphocytes. |
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Definition
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Term
| 5. _____ are leukemias derived from lymphoid stem cells of B and T cells. |
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Definition
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Term
| 6. _____ leukemias are derived from myeloid stem cells (granulocytes). |
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Definition
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Term
| 7. Since leukemias are classified based on their state of maturity of cell/clinical presentation that can either be _____ or _____. |
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Definition
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Term
| 8. Acute leukemias consist of _____ due to a block in differentiation of stem cell precursors. |
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Definition
| IMMATURE NEOPLASTIC CELLS |
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Term
| 9. Neoplastic cells of acute leukemias can be of _____ or _____ stem cell origin. |
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Definition
| LYMPHOCYTIC OR MYELOGENOUS |
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Term
| 10. 3 clinical features of acute leukemias. |
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Definition
| 1) ABRUPT STORMY ONSET, 2) FULMINANT CLINICAL COURSE, 3) FATAL IN UNTREATED PATIENTS |
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Term
| 11. 6 symptoms related to the depression of normal marrow functioning in acute leukemias. |
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Definition
| 1) FATIGUE, 2) FEVER, 3) THROMBOCYTOPENIA, 4) BONE PAIN, 5) ORGANOMEGALY, 6) CNS INVOLVEMENT IN CHILDREN |
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Term
| 12. _____ is a decrease in blood clot formation due to a decrease in platelet count. |
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Definition
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Term
| 13. _____ leukemias consist of more well differentiated mature leukocytes, neutrophils or lymphocytes. |
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Definition
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Term
| 14. 9 clinical presentations of chronic leukemias. |
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Definition
| 1) SLOW INSIDIOUS ONSET, 2) INDOLENT CLINICAL COURSE, 3) ELEVATED WBC COUNT, 4) VAGUE SYMPTOMOLGY, 5) ANEMIA, 6) FATIGUE, 7) WEAKNESS, 8) WEIGHT LOSS, 9) ORGANOMEGALY |
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Term
| 15. _____ leukemias consist of 90% of all childhood leukemias. |
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Definition
| ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) |
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Term
| 16. Acute lymphoblastic leukemias affect _____ cells. |
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Definition
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Term
| 17. 3 characteristics of acute lymphoblastic leukemia. |
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Definition
| 1) TRANSFORMED B-CELLS ARE MYELOPEROXIDASE NEGATIVE, 2) CNS INVOLVEMENT, 3) DRAMATIC ADVANCES IN TREATMENT (GOOD PROGNOSIS) |
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Term
| 18. _____ is an enzyme in neutrophils responsible for making free radicals that is used to test for lymphoblastic leukemias. |
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Definition
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Term
| 19. _____ makes up 90% of all adult acute leukemias between the ages of 15-40. |
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Definition
| ACUTE MYELOID LEUKEMIA (AML) |
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Term
| 20. Acute myelotic leukemias affect _____ cells. |
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Definition
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Term
| 21. Patients with acute myeloid leukemia are _____ and _____ positive. |
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Definition
| AUER ROD AND MYELOPEROXIDASE POSITIVE |
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Term
| 22. Acute myeloid leukemias are difficult to _____ causing frequent _____. |
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Definition
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Term
| 23. _____ make up 25% of all leukemias affecting older males and it affects mature lymphocytes (B-cells). |
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Definition
| CHRONIC LYMPHOCYTIC LEUKEMIAS (CLL) |
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Term
| 24. _____ is the leukemic counterpart of small follicular lymphoma. |
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Definition
| CHRONIC LYMPHOCYTIC LEUKEMIA |
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Term
| 25. Chronic lymphocytic leukemias affect _____ cells. |
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Definition
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Term
| 26. 5 characteristics of chronic lymphocytic leukemia. |
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Definition
| 1) ASYMPTOMATIC OR VAGUE SYMPTOMS, 2) COMMON INFECTIONS, 3) FATIGUE, 4) ORGANOMEGALY, 5) SLOW GROWING |
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Term
| 27. Chronic lymphocytic leukemias are difficult to _____. |
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Definition
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Term
| 28. _____ are chronic leukemias that cause 15-20% of all leukemias. It most often affects fairly mature granulocytes. |
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Definition
| CHRONIC MYELOID LEUKEMIA (CML) |
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Term
| 29. Chronic myeloid leukemias contain _____ chromosome translocation resulting in bcr-c-abl gene expression. |
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Definition
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Term
| 30. Chronic myeloid leukemias mainly affect _____ cells. |
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Definition
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Term
| 31. Chronic myeloid leukemias are difficult to treat due to the _____. |
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Definition
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Term
| 32. Chronic myeloid leukemias cause _____ symptomology. |
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Definition
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Term
| 33. _____ is when patients with chronic myeloid leukemia revert back to acute myeloid leukemia. |
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Definition
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