Term
| Hematopoiesis 18th day after fertilization |
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Definition
| extraembryonic location, the yolk sac |
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Term
| intraembryonic hematopoiesis |
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Definition
| aorta-gonads-mesonephro region |
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Term
| 3rd month of fetal development |
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Definition
| spleen, kidney, lymph nodes and thymus |
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Term
| late fetal and neonatal stages --> 6th month of gestation |
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Definition
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Term
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Definition
| produces erythrocytes and macrophages |
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Term
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Definition
| primitive erythrocytes and lymphocytes |
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Term
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Definition
| erythroid, myeloid and lymphoid cells |
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Term
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Definition
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Term
| Primary Lymphoid function |
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Definition
| develop T and B cells from nonfunctional precursors |
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Term
| Secondary Lymphoid Tissues |
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Definition
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Term
| Secondary Lymphoid function |
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Definition
| posses immunocompetent T and B cells in response to antigen |
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Term
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Definition
| spleen becomes enlarged through exaggeration of is normal activities of filtering and phagocytosis and cause anemia, leukopenia, thrombocytopenia or other combinations of cytopenias (decrease) |
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Term
| Conditions for Hypersplenism |
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Definition
| (1) presence of anemia, leukopenia, or thrombocytopenia in the peripheral blood (2) existence of a cellular or hyperplastic bone marrow corresponding to the peripheral blood cytopenia and (3) occurence of splenomegaly (enlargement) |
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Term
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Definition
| occurs when no underlying disease can be identified |
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Term
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Definition
| secondary to workload hypertrophy of the spleen |
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Term
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Definition
| enlargement of the lymph nodes by expansion of the tissue within the node |
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Term
| causes of lymphadenopathy |
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Definition
| inflammation of the lymph node, prolonged immune response to infectious agents, malignant transformation of lymphocytes or macrophages or metastatic tumors that originate in extranodal sites |
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Term
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Definition
| excessive development of hematopoietic cells which occurs with all conditions of increased or ineffective hematopoiesis |
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Term
| Changes that lead to Bone Marrow hyperplasia |
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Definition
| hematopoietic tissue becomes inactive and fat cells increase caused by acute blood loss, chronic anemia or leukemia |
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Term
| extramedullary hematopoiesis |
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Definition
| blood cell production in hematopoietic tissue other than the bone marrow |
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Term
| changes that lead to extramedullary hematopoiesis |
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Definition
| hyperplasia of the marrow does not meet the physiologic needs of the tissues, usually accompanied by splenomegaly |
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Term
| sites of extramedullary hematopoiesis |
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Definition
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Term
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Definition
| blood forming tissue in spongy bone, composed of vascular and hematopoietic compartments |
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Term
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Definition
| enclosed by a capsule of connective tissue, made up of three zones of tissue (1) white pulp (2) red pulp (3) marginal zone |
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Term
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Definition
| composed of lymphocytes and germinal centers, located around a central artery |
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Term
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Definition
| contains sinuses and cords |
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Term
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Definition
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Term
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Definition
| bean-shaped organs in groups or chains along the larger lymphatic vessels, contain an outer cortex and an inner medulla |
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Term
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Definition
| outer cortex and inner medulla |
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Term
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Definition
| one of the three major cells that make of the stroma, cytoplasm replaced by a fat vacuole, control the volume of bone marrow in which active hematopoiesis takes place |
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Term
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Definition
| discriminatory spleen filtering and destruction of senescent or damaged red cells |
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Term
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Definition
| the inner lining of the cortical bone |
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Term
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Definition
| single macrophage surrounded by erythroblasts in varying stages of maturation, development site of erythroblasts |
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Term
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Definition
| location of activated B cells in the spleen |
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Term
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Definition
| location of the germinal centers on the spleen |
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Term
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Definition
| involved in the formation of calcified bone and provide a niche for resting hematopoietic stem cells |
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Term
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Definition
| cells related to macrophages that are involved in resoprtion and remodeling of calcified bone |
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Term
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Definition
| spleens ability to pluck out particles from intact red blood cells without destroying them |
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Term
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Definition
| supports endothelial cells in the sinuses, they gather into one collecting sinuses which opens into a vein, produce reticular fibers which contribute to the 3-D supporting network that holds the vascular sinuses and hematopoietic elements |
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Term
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Definition
| support tissue of the bone marrow, forms a favorable microenvironment for sustained proliferation of hematopoietic cells |
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Term
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Definition
| projection of calcified bone extending from cortical bone into the marrow space, it provides support for the marrow cells |
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Term
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Definition
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Term
| Hypersplenism associated with compensatory hypertrophy of the spleen |
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Definition
| seen when splenic macrophages accumulate large amounts of undigestible substances |
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