Term
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Definition
GTPase activating protein
- increases the innate GTPase activity |
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Term
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Definition
GDP dissociation inhibitor
- sequesters GDP-ras in an inactive state |
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Term
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Definition
Guanosine nucleotide exchange factor
- catalyzes GDP release to allow GTP binding |
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Term
| Receptor Tyrosine Kinases |
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Definition
| activate Ras-GEFs when bound |
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Term
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Definition
| regulated cell proliferation |
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Term
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Definition
nuclear import cycling
- facilitates nuclear protein dissociation and cycling of Importin |
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Term
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Definition
| targeted vesicle trafficking |
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Term
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Definition
| targets bound vesicles to specific sites |
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Term
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Definition
regulated actin nucleation
- formation of Stress Fibers |
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Term
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Definition
| formation of lamellapodia |
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Term
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Definition
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Term
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Definition
| protrusive, membrane periphery, orthogonal arrays |
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Term
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Definition
| protrusive, membrane periphery, bundled filaments |
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Term
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Definition
| contractive, cell interior, bundled filaments |
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Term
| Post-translational modification of Rho family |
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Definition
isoprenylation of c-terminal cysteine
- tagging a protein to a lipid and anchors Rho, Rac, and Cdc42 at the plasma membrane |
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Term
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Definition
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Term
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Definition
| ATP-dependent motor (highly conserved) |
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Term
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Definition
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Term
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Definition
| defines cargo (most variable region) |
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Term
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Definition
| transmembrane proteins in focal adhesions |
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Term
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Definition
| (MyoII inhibitor) inhibits integrin migration |
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Term
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Definition
| driven by short Actin filaments extending from Arp2/3-nucleated dendritic networks |
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Term
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Definition
bundled actin protrusions at the leading edge
- emerge from existing dendritic filaments |
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Term
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Definition
enables barbed end growth
- promotes barbed end addition
- inhibits capping protein binding
- activated by Cdc42 |
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Term
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Definition
| filament bundling protein found in filopodia precursors |
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