Term
| How is the CNS activated? |
|
Definition
| pro-inflam cytokines bind to neurons of the SNS & PNS, diffuse into brain or are produced within the brain |
|
|
Term
| Activation of which part of the brain triggers the sickness response? |
|
Definition
|
|
Term
| What triggers the fever response? |
|
Definition
| IL-1, IL-6 & TNF-alpha induce prostaglandin synthesis |
|
|
Term
| What effects does fever have on immune cells? (3) |
|
Definition
-enhances DC maturation
-increases number of circulating lymphocytes
-inhibits T cell apoptosis |
|
|
Term
| How do poikilotherms generate a fever response? |
|
Definition
| swimming in warmer waters |
|
|
Term
| Which interleukin promotes the release of serotonin? |
|
Definition
|
|
Term
| How does IL-1 lead to anorexia? |
|
Definition
-suppresses neuropeptide-Y (a hunger signal)
-induces production of HMGB1 (causes food aversion) |
|
|
Term
| Which 3 components of the immune system induce HMGB1 production? |
|
Definition
|
|
Term
| How are bone marrow equivalent tissues activated? |
|
Definition
| G-CSF production is increased, which stimulates neutrophil differentiation |
|
|
Term
| Which interleukin is especially important in heptic synthesis of APP? |
|
Definition
|
|
Term
| Which APPs are produced in the liver? |
|
Definition
PRO CIBC
Proteolytic enzyme neutralizers
Radical scavengers
Opsonins
Complement proteins
Iron binding proteins
Binding proteins
Clotting factors |
|
|
Term
| Major APPs can increase in concentration by up to... |
|
Definition
|
|
Term
| Moderate APPs can increase in concentration by up to... |
|
Definition
|
|
Term
| Are major, moderate & minor APPs positive or negative? |
|
Definition
|
|
Term
| Is C-reactive protein positive or negative? |
|
Definition
|
|
Term
| Which receptors bind C-reactive protein? |
|
Definition
|
|
Term
| Is C-reactive protein pro or anti inflammatory? |
|
Definition
| anti (inhibits neutrophil degranulation) |
|
|
Term
| Is Serum amyloid A positive or negative? |
|
Definition
|
|
Term
| Serum amyloid A is an alarmin via ____ |
|
Definition
|
|
Term
| Is Serum amyloid A pro or anti inflammatory? |
|
Definition
| pro (attracts neuts & mono) |
|
|
Term
| Transferrin is negative in _____ and positive in ____ |
|
Definition
mammals
chickens & zebrafish |
|
|
Term
| Haptoglobin is ______ in mammals and _____ in chickens |
|
Definition
|
|
Term
| MAP protein is major in which species? |
|
Definition
|
|
Term
| MAP protein is minor in which species? |
|
Definition
|
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