Term
| What are some of the immune mediated skin diseases seen in small animals? |
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Definition
-pemphigus
-discoid lupus
-SLE
-vasculitis
-sebaceous adenitis
-VKH
-sterile pyogranulomatous dermaitis |
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Term
| What is the term for inflammation and exudate around the base of the nail? |
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Definition
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Term
| If you see a case of what looks like ringworm but with exudate around the nails and acanthocytes on cytology, what is it? |
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Definition
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Term
| How do we treat a cat with pemphigus follaceous? |
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Definition
| -corticosteroids with cyclosporine |
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Term
| How do we trat a dog with pemphigus foliaceous? |
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Definition
| -corticosteroids with azothioprine |
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Term
| IN addition to lesions around the nail bed, where else do we see lesions that point to pemphigus foliaceous and away from ringworm? |
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Definition
| -foot pads with exudate, inflammation, and redness |
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Term
| What do we see on histopath that diagnoses pempigus foliaceous? |
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Definition
| -acantholytic epithelial cells |
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Term
| What is the most common immune mediated skin disease in dogs and cats? |
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Definition
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Term
| What physiologically happens with pemphigus foliaceous? |
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Definition
| -auto-antibodies attack intercellular cohesive proteins in the upper epidermis (subcorneal) |
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Term
| Where do we see pustular lesions due to pemphigus foliaceous? Is it pruritic? |
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Definition
-foot pads, nail beds, all over
-can be pruritic |
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Term
| How do we treat penphigus foliaceous? |
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Definition
-Corticosterioids with Azathioprine or Cyclosporine
-can also use Mycophenolate |
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Term
| Describe the presentation of DLE in the dog. |
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Definition
| -depigmentation and erosions of the nose and crusty erosive lesions of the ear margins along the basement membrane |
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Term
| HOw do we treat DLE in dogs? |
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Definition
-Doxy, niacinamide, pentoxfylline, and prednisone
-can also use Tacrolimus topically
=sun screens |
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Term
| What does DLE look like on histopath? |
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Definition
| -interface dermatitis with pigmentary incontinence |
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Term
| What is the alternative name for superficial necroltic dermatitis? |
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Definition
| -hepatocutaneous syndrome |
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Term
| How do wwe confirm superficial necrolytic dermaittis? |
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Definition
| -skin biopsy and liver profile with US |
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Term
| What conditions can predispose dogs to superficial necrolytic dermatitis? |
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Definition
| -liver fialure, diabetes mellitus, long-term phenobarbital use |
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Term
| How do we diagnose SND on hoistopath? |
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Definition
-use Trichrome stain
-characteristic red, white, and blue appearance |
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Term
| What do we see on the liver of dogs with SND? |
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Definition
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Term
| What external lesions do we see due to SND? |
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Definition
| -hyperkeratosis and crusts around painful and cracked foot pads |
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Term
| HOw does pemphigus vulgaris present? |
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Definition
| -non-healing erosions around the mucus membranes |
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Term
| How do we treat pemphigus vulgaris? |
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Definition
-immunosuppressive doses of prednisone
-Mycophenolyte
-Cyclosporine |
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Term
| HOw does epitheliotrophic lymphoma present in the dog? |
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Definition
-plaques around the mucocutaneous junctions
-inflamed erythematous plaques
-inflamed oral mucosa |
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Term
| What is the first thing we do with mucocutaneous erosions? |
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Definition
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Term
| What are the rule outs for mucocutaneous erosions? Clues? |
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Definition
-Mucocutaneous pyoderma: nor oral lesions and has crusted papules
-Pemphigus vulgaris: mucosal erosions and ulcers
-Epitheliotrophic lymphoma: plaques |
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Term
| Describe the multisystemic effects of Systemic Lupus Erythematosus. |
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Definition
| -polyarthritis, glomerulonephritis, immune-mediated hemolytic anemia |
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Term
| Describe the pathogenesis of SLE. |
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Definition
| -autoantibodies against DNA or RNA |
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Term
| WHat kinds of skin lesions can occur due to SLE? |
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Definition
-erosive to proliferative lesions
-face
-mucus membranes
-feet
-extremities |
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Term
| What is the etiology of Uveodermatologic Syndrome aka Vogt-Koyanagi-Harada Syndrome? |
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Definition
| -immune mediated against melanocytes |
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Term
| What breed of dogs is the poster child for VKH? |
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Definition
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Term
| What are the ophthalmic clinical signs of VKH? Derm signs? |
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Definition
-O: severe bilateral uveitis with retinal detachment
-D: depigmentation, ulceration |
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Term
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Definition
-lifelong systemic immunosuppressive therapy
-topical prednisolone, atropine |
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Term
| What is immune mediated vasculitis? Outcome? |
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Definition
-severe full thickness necrosis of skin
-euthanisia |
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Term
| Which breed is predisposed to sterile pyogranulomatous dermatitis? Lesions? |
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Definition
-young labs
-acute onset of very pruritic nodular dermaitis of face |
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Term
| How do we treat sterile pyogranulomatous dermatitis? |
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Definition
| -high dose corticosteroids |
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