Term
| What are 4 reasons to screen for novel exometabolites |
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Definition
to detect new and useful biological and pharmacological activity
to find new and patentable structures for semi synthesis, analogue development
to find new related strucutres with reduced side effects, broader spectrum, better delivery, patentability |
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Term
| what are the critical limitations of metbolomics (transcriptome, proteasome, when searching for genes encoding antibiotic biosynthesis enzymes? |
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Definition
| growth conditions, metabolite detection |
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Term
| What are the 6 chemical classes of antibiotics? |
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Definition
1. beta lactams
2. b lactamase inhibitors
3. aminoglycosides
4. tetracyclines, polyketides
5. macrolides
6. peptides |
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Term
| The antiinfective compound market is ___ and ___ |
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Definition
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Term
| since only __% of all soil microbes can be grown in the lab, __may open the door to a host of previously inaccessible antibiotic biosynthetic genes from unculturable microbes |
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Definition
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Term
| why search for new antibiotics? |
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Definition
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Term
| in regards to penicillin and vancomycin, provide the year of FDA approval, year of first reported resistance event, observed resistance, and subsequent drugs developed to counteract the resistant strain |
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Definition
penicillin 1943, first reported resistance 1940
drugs developed - cephalosporins, oxacillin
vancomysin 1972, 1987, quiopristomn |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| chloramphenicol tetracyclines |
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Term
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Definition
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Term
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Definition
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Term
| New methods developed by ___ screening are being used to detect new compounds synthesized by ___ |
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Definition
| genomics, silent biosynthetic pathways |
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Term
| What results were achieved from 1930 to 1960 with regards to core structures and what new methods were developed from 1990 to 2010 that enabled genomic screening for sbps? |
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Definition
1930-1960- (penicillin, streptomycin, DNA, bacterial operon sequenced)
1990-2010- fully microbial gene sequenced, structures predicted from gene sequence, co-culture technique) |
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Term
| based on the diagram below identify each step in the overall screening process in novel lead compounds |
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Definition
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