Term
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Definition
| a solid doage form intended for insertion into a body orifice where it melts, softens or dissolves and exerts local or systemic effects |
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Term
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Definition
1. alternative to oral route
2. bypass the first pass effect.
3. large dose drugs
4. safe, painless, and easy to administer
5.can be used on drugs that usually irritate in other dosage forms.
6. can control the duration of action |
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Term
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Definition
1. unpopular route
2. leakage
3. unpredictable drug absorption
4. potentioal for irritation
5. upward movement can incrfease first pass metabolism
5. harder to self administer |
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Term
| what would consitute an ideal suppository? |
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Definition
1. non-irritating
2. compatible with active ingredients
3. uniform distribution of active ingredients throughout the dosage form.
4. physically intact- not brittle, crumbling etc |
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Term
| the state of the rectum when it is empty? |
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Definition
| its 15-20 cm long and has 2-3 ml of fluid |
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Term
| factors taht affect the rectal absorption? |
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Definition
| colonic content, circulation route, pH and lack of buffering capacity of the rectal fluids |
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