Term
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Definition
| *Clinical effects or pharmacokinetics of a drug are altered by administration of a combination of drugs |
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Term
| Determining Clinical Significance of Drug Interaction |
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Definition
1. Onset (rapid/delayed)
2. Severity (major, moderate, minor)
3. Documentation (studies, reports)
4. Drugs with narrow therapeutic window |
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Term
| Two Mechanisms of Drug Interactions |
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Definition
| Pharmacodynamic or Pharmacokinetic |
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Term
| Pharmacodynamic Drug interactions |
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Definition
one drug induces a change in a patient's response to a drug without altering the pharmacokinetics
*Antagonistic or Synergistic |
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Term
| Antagonistic Pharmacodynamic Drug Interactions |
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Definition
| two drugs have opposite effects, cancel each other out |
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Term
| Synergistic/Additive Pharmacodynamic Drug interactions |
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Definition
| Additive CNS effects, additive side effects, additive cardiac depression, additive arrhythmogenic effect (QT prolonged), additive anticoagulant/antiplatelet effects, additive antibacterial effects |
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Term
| Pharmacokinetic Drug Interactions |
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Definition
| one drug alters the rate or extent of ADME of another drug |
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Term
| Pharmacokinetic DI: Absorption |
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Definition
| GI motility, GI pH, Inactivation/Chelation, Altered Bacterial flora, reduced or prevented enterohepatic circulation, P-glycoprotein transporter |
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Term
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Definition
| metoclopramide speeds gastric emptying |
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