Term
|
Definition
the relative amount of administered dose that reaches the general circulation and the rate at which it reaches the general circulation.
intravascular administration is 100% bioavailable vs extravascular (eg oral) which may not be |
|
|
Term
|
Definition
| process by which the drug molecules will proceed from the site of administration to the site of measurement. |
|
|
Term
|
Definition
| the directly proportional relationship between the concentration of drug in the body and the dose administered. |
|
|
Term
|
Definition
| How long it will take for 50% of the drug to disappear from body. 7 half-lives to eliminate 99% of med from body. |
|
|
Term
| peak plasma concentration |
|
Definition
| the highest plasma concentration of drug in the body for the dose that is administered. |
|
|
Term
| Pharmaceutics consists of what sciences? |
|
Definition
| Physical Pharmacy, Dosage Forms, biopharmaceutics, pharmacokinetics, Industrial pharmacy |
|
|
Term
|
Definition
| understanding and applying the principles of physical chemistry and mathematics in characterizing important properties of solid and liquid therapeutic agents as well as inactive ingredients. These properties are in turn used to help in development, formulation, manufacturing and evaluation of various dosage forms |
|
|
Term
|
Definition
| science and study of small particles. A part of physical |
|
|
Term
|
Definition
| current good Manufacturing Practices |
|
|
Term
|
Definition
| good laboratory practices |
|
|
Term
|
Definition
| the study of the factors influencing the bioavailability of a drug and the use of this information to optimize pharmacological and therapeutic activity of drug pdts. |
|
|
Term
|
Definition
| the study of kinetics of absorption, distribution, metabolism and elmination (ADME) of drugs and their corresponding pharmacologic, therapeutic or toxic responses in man and animals |
|
|
Term
|
Definition
| The time (units) at which the administered drug reaches the therapeutic range or it begins to produce the effect |
|
|
Term
|
Definition
| the time span (units) beginning the onset of action up to the termination of action |
|
|
Term
|
Definition
| the plasma or serum concentration (ug/ml; ng/ml; etc) range, within which, the drug is likely to produce the therapeutic activity or effect. |
|
|
Term
|
Definition
| the time (units) at which the drug concentration in the plasma falls below the minimum effective concentration (MEC) |
|
|
Term
|
Definition
| the accumulation/binding of atoms, molecules or particles on the surface of a material |
|
|
Term
| Delta Hv- Molar heat of vaporization |
|
Definition
| heat absorbed by 1 mole of liquid when it passes into the vapor phase. in cal/g or cal/mol |
|
|
Term
|
Definition
| temperature at which vapor pressure of a liquid equals the atmospheric pressure |
|
|
Term
| Equilibrium/Saturation Solubility |
|
Definition
| MAXIMUM amount (mg, g) of a solute or drug that is present in a solution form per unit volume (mL or L) of a solvent at a constant temperature and pressure |
|
|
Term
|
Definition
| the condition when the rate of transfer of a solid in to the solvent and the rate of deposition of solute molecule from the solvent on to the solid crystal become equal |
|
|
Term
|
Definition
| the maximum amount (mg) of solute present in a solution form per unit volume (mL, L) of a solvent at a constant temperature and pressure, following the attainment of the equilibrium condition. |
|
|
Term
|
Definition
| phenomenon where a substance may be capable of xtallizing in more than one xtalline form. |
|
|
Term
|
Definition
| When the change from one polymorphic form to another form is reversible by varying temperature or pressure. |
|
|
Term
|
Definition
| When the transition from one (polymorphic) form to another takes place in only one direction, ie metastable to stable OR one polymorphic form is unstable at all temperatures and pressures. |
|
|
