Term
| Physiological functions of glucocorticoids |
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Definition
Modulation of glucose metabolism and stress response. By inhibits glycogen synthesis and induction of gluconeogenesis
Induces surfactant in young kids
Regulates apoptosis
modulation of neuronal function. Complex procedure of hippocampus, memory and learning. |
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Term
| Regulation of Glucocorticoid secretion |
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Definition
| Hypothalamus releases CRH, and pituitary secretes ACTH and pregnenolone and that releases cortisol. Increased levels of cortisol negatively affects the release of ACTH and CRH. |
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Term
| Mechanism of Action for glucocorticoid |
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Definition
| Transpression of gene transcription. It is thought to be a main factor in antiinflammatory and immunosuppressive response. |
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Term
| Explain the catabolic effects on fat, fibroblast and muscle. |
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Definition
Inhibits type I and II collagen production and decreases chemotactic and proliferation response to cytokines
Increases protein breakdown for gluconeogenesis and decreases protein synthesis.
Breaks down fat and but causes insulin dependent lipogenesis. |
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Term
| Name all the short acting, Intermediate and long acting Glucocorticoid agents. |
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Definition
1. Cortisone, hydrocortisone, prednisone and methylprednisone.
2. Triamcinolone and fluprednisone
3. betamethasone and dexamethasone |
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Term
| List the therapeutic affects of glucocorticoids |
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Definition
| Antiinflammation, chemotherapy, harmone replacement therapy, and immunosuppression. |
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Term
| Name four genes whose transcription is induced during inflammatory response. |
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Definition
Map Kinase phosphatase 1
IkB
macrocortin/lipocortin
tristetraprolin |
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Term
| How do Glucocorticoid work in Leukemia and Prostate cancer |
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Definition
Glucocorticoids induce transformed T cells to undergo apoptosis.
Glucocorticoids slows the cell progression in the transformed prostate cells. |
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Term
| What is the substitution therapy is used for? |
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Definition
Addison's disease, caused due to atrophy of adrenal cortex. So glucocorticoids help with atrophic adrenals.
Adrenal tumor.
congenital adrenal hypertrophy. It is genetic defect in 21b hydroxylase. |
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