Term
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Definition
| Bind Cytoplasmic Receptors, Receptor/Hormone complex enters nucleus activating transcription of proteins leading to hormone response |
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Term
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Definition
| Bind Membrane Receptor, GTP Activation of AC produces cAMP which activates PKinase which leads to phosphorylation of substrates and hormone effect/response |
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Term
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Definition
| DNA recombinant Growth Hormone, used in the treatment of Pituitary Dwarfism |
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Term
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Definition
| DA Agonist, used for Paridoxical inhibitory effect on Growth Hormone release (Tx Acromegaly) ALSO Dopamine inhibits Prolactin Release (Tx Hyperprolactinemia) |
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Term
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Definition
| Analog of Somatostatin with a long half life. Inhibits GH release and is used in the Tx of esophogeal Varices by decreasing portal pressure |
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Term
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Definition
Stimulates Growth and development of Mammary Glands
Causes Lactation after Delivery
Can enhance tumor growth and incidence of breast tumors |
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Term
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Definition
| Circulating Angiontensin II and K+ regulate production of Aldosterone |
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Term
| Zona Fasciculata/Reticularis |
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Definition
| ACTH Stimulates production of Cortisol and Androgens |
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Term
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Definition
| Leads to formation of Cortisol and Corticosterone |
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Term
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Definition
| Required for formation of Cortisol and Androgens |
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Term
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Definition
| When blocked, fully blocks Cortisol and Mineralcorticoid formation. (Salt-Wasting) |
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Term
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Definition
| Synthetic ACTH, Used to Access state of adrenal cortex |
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Term
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Definition
| Primary Adrenal Insufficiency. Deficient Cortisol due to diseased adrenal cortex, Excess ACTH and Hyperpigmentation |
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Term
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Definition
| Secondary Adrenal Insufficiency. Deficient Cortisol due to insufficient ACTH production by Pituitary. Cortex will respond to ACTH, but response my not be normal due to Cortex atrophy from decreased stimulation. |
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Term
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Definition
| Pituitary Dependent Adrenal Hyperplasia-Excessive Cortisol. Excess ACTH Secretion (adenoma of PITUITARY). More cortisol required for negative feedback, but will eventually be able to see negative feedback response. |
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Term
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Definition
Excessive Cortisol from Multiple Possible Causes
1) Adrenal Adenoma- Not ACTH Dependent
2) ACTH secreting ectopic tumor (normally in Lung)
3) Excessive Tx with Steroids |
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Term
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Definition
Antifungal that also blocks 17 Alpha-Hydroxylase
Blocks formation of Cortisol and Androgens |
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Term
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Definition
Blocks the conversion of Cholesterol to Pregnenolone decreasing the synthesis of all corticosteroids.
Useful in the Tx of Breast Cancer because it Also blocks Aromatase therefore decreased Estrogen formation |
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Term
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Definition
| Blocks 11 Beta-Hydroxylase. Used in the diagnosis of adrenal insufficiency by checking ACTH and Cortisol precursor levels after administration. |
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Term
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Definition
| Pure Glucocorticoid with very long duration of action (36-72hours) Used to Tx inflammation and Autoimmune |
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Term
| Prednisone, Prednisolone, Methylprednisolone |
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Definition
| Glucocorticoid with minimal Mineralcorticoid action |
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Term
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Definition
| Pure Mineralcorticoid Used to Tx Salt Wasting |
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