Term
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Definition
| The process by which the body stops the leakage of blood from the vascular system after injury. |
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Term
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Definition
| Sequential process by which multiple plasma enzymes and cofactors interact. |
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Term
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Definition
| slow and continuous degradation of fibrin clots. |
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Term
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Definition
| occurs in small injuries to the blood vessels, includes the formation of a platelet plug and introduction of coagulation factors. |
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Term
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Definition
| Necessary to control bleeding from large wounds. |
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Term
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Definition
PRIMARY
Stage 1 - Vasoconstriction
Stage 2 - Platelet Plug Formation
SECONDARY
Stage 3 - Fibrin Clot Formation
Stage 4 - Fibrinolysis |
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Term
| Stage 1 - Vasoconstriction |
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Definition
| damage blood vessel constricts, decreasing blood flow to injury. |
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Term
| Stage 2 - Platelet Plug Formation |
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Definition
| Platelets clump together and adhere to injury, forming plug. Coag. factors present in blood and tissue interact to form clot. |
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Term
| Stage 3 - Fibrin Clot Formation |
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Definition
| Coag. Facotrs in the blood and tissue interact to form a fibrin clot to stop blood flow. Fibrin clot is formed through The Coagulation Cascade. |
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Term
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Definition
| When blood flow stops the clot is dissolved. Keeps the vascular system free of fibrin and fibrin clots. Mediated by Plasmin which gradually breaks down the clot. |
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Term
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Definition
| The activation of 12 different coag factors or proteins, in sequence. |
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Term
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Definition
| Smallest in diameter, most numerous, injuries usually mended by direct sealing. |
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Term
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Definition
| Mended by vasoconstriction, fusion of platelets and factor activation. |
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Term
| Tunica Externa (Adventitia) |
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Definition
| Thin, outtermost layer. Connect tissue cell support. Attaches vessel to surrounding tissues. |
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Term
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Definition
| Middle layer, smooth muscle and elastic muscle. Serves in vasoconstriction during Primary Hemostasis. |
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Term
| Tunica Intima (endothelium layer) |
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Definition
| Innermost single layer. Unexposed and intact endothelium layer. Non-reactive with platelets and unable toinitiate cascade. |
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Term
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Definition
| >50,000 are required for normal hemostasis. Participate in primary hemostasis by forming plt. plug. Participate in secondary hemostasis by providing binding sites for coag proteins. |
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Term
| Platelet Role in Hemostasis |
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Definition
| Play a role in both the formation of a primary plug as well as the coagulation cascade. A break in the lumen initiates a series of platelet reactions. |
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