Term
| What STDs are considered "drips" or discharges? |
|
Definition
| Gonorrhea, Chlamydia, Nongonococcal urethritis/mucopurulent cervicitis |
|
|
Term
| What STDs cause sores or ulcers? |
|
Definition
| Syphillus, Genital herpes, Lymphogranuloma venereum, Chancroid, Granuloma inguinale |
|
|
Term
| Is urethritis from gonorrhea more common in men or women? Peak age of incidence? |
|
Definition
| Equal. M: 20-24yo, F: 15-19yo, peak 15-29yo. |
|
|
Term
| What is the etiologic agent of Urethritis Gonorrhea? |
|
Definition
|
|
Term
| What does N. gonorrheae infect anatomically? |
|
Definition
| mucous-secreting epithelial cells |
|
|
Term
| Where is there an endemic of quinolone resistant N. gonorrhae? |
|
Definition
|
|
Term
| Sx of gonorrheal urethritis? |
|
Definition
|
|
Term
| What is a common complication of gonorrhea urethritis? |
|
Definition
|
|
Term
| Name 6 uncommon sx of gonorrhea urethritis. |
|
Definition
| 1) Inguinal lymphadenitis 2) Penile edema 3) Periurethral abscess 4) Urethral stricture 5) Balanitis 6) Prostatitis |
|
|
Term
| What is the primary site of infection of gonorrhea causing urogenital infxn in women? |
|
Definition
| endocervical canal, also colonizes the urethra |
|
|
Term
| Sx. of gonnorhea urogenital infxn in women? |
|
Definition
| 50% asymptomatic, vaginal d/c, dysuria, labial pain/swelling, abd pain |
|
|
Term
| What are complications of gonorrhea urogenital infxn in women? |
|
Definition
| accesory gland infxn, PID, perihepatitis (Fitz-Hugh-Curtis Syndrome) |
|
|
Term
| Is disseminated gonococcal infection causing bacteremia more common in men or women? |
|
Definition
|
|
Term
| what is dermatitis-septic arthritis syndrome? What is it a clinical manifestation of? |
|
Definition
| Triad of dermatitis, polyarthritis, and tenosynovitis. Disseminated gonococcal infxn. |
|
|
Term
| Name 4 other clinical manifestations of disseminated gonoccal infection. |
|
Definition
| 1) Hepatitis 2) Myocarditis 3) Endocarditis 4) Meningitis |
|
|
Term
| What is found on urine dipstick in gonorrhea? |
|
Definition
| (+) leukocyte esterase on first void urine |
|
|
Term
| What selective growth culture media is used to dx gonorrhea infxn? |
|
Definition
| Thayer-Martin chocolate agar |
|
|
Term
| What is the CDC rec. for tx of gonorrhea infxn since 2007? |
|
Definition
| Cefixime (suprax) or ceftriaxone + tx for chlamydia if not r/o |
|
|
Term
| What is the most common etiologic agent in the infxn of nongonococcal urethritis? |
|
Definition
|
|
Term
| What is the second most common etiologic agent for nongonococcal urethritis? Other causes? |
|
Definition
| Genital mycoplasmas. Occasionally Trichomonas vaginalis, HSV, or Candida. Unknown in ~50% of cases. |
|
|
Term
| Sx of nongonococcal urethritis? |
|
Definition
| mild dysuria and mucoid discharge |
|
|
Term
| Chlamydia trachomatis can be transmitted to the newborn during delivery, what does it cause? |
|
Definition
|
|
Term
| Name 4 complications of Chlamydia trachomatis. |
|
Definition
| 1) Epidymitis 2) PID 3) Perihepatitis 4) Reiter's syndrome |
|
|
Term
| What test has the ability to detect Chlamydia in the first void urine? |
|
Definition
| Ligase chain reaction (LCR) |
|
|
Term
| What is the standard lab test for Chlamydia? |
|
Definition
|
|
Term
| Tx for chlamydia trachomatis? |
|
Definition
| Azithromycin or Doxycycline |
|
|
Term
| What is the most common STD syndrome in women? |
|
Definition
| STDs characterized by Cervicitis |
|
|
Term
| Name 4 primary etiologic agents of cervicitis. |
|
Definition
| N. gonorrhae, C. trachomatis, HSV, HPV |
|
|
Term
|
Definition
| 1) Purulent cervical d/c 2) Cervical edema 3) Inc. menses 4) Dysmenorrhea 5) Dyspareunia 6) Dysuria |
|
|
Term
| Differentiate b/t cervicitis from C. trachomatis and HSV. |
|
Definition
| C. trachomatis - mucopurulent d/c, nonspecific abd pain, spotting w/ intercourse, 20-70% normal appearing cervix. HSV - mucoid d/c, lower abd pain, friable cervix w/ ulcers or gangrene. |
|
|
Term
| What is the etiologic agent in cervicitis if multinucleated giant cells with intranuclear inclusions are seen? |
|
Definition
|
|
Term
| Dx testing for cervicitis? |
|
Definition
| gram stain of endocervical mucus, cervical cytology, nonamplified and amplified tests |
|
|
Term
| What is the tx for recurrent/persistent urethritis/cervicitis? |
|
Definition
| Metronidazole PLUS erythromycin |
|
|
Term
| What bacteria causes syphilis? |
|
Definition
| Treponema palidum, spirochete |
|
|
Term
| What are the 2 painful genital ulcer diseases? |
|
Definition
| Genital HSV and chancroid |
|
|
Term
| What are the 3 painless genital ulcer diseases? |
|
Definition
| syphilis, lymphogranuloma venereum, and granuloma inguinale |
|
|
Term
| what is the most common cause of genital ulcer disease in North America and Europe? |
|
Definition
|
|
Term
| what is the gold standard test for HSV? |
|
Definition
|
|
Term
| What is seen on Tzank smear in HSV? |
|
Definition
| multinucleated giant cells |
|
|
Term
| Which rapid serology test can differentiate b/t HSV 1&2 and which can't? |
|
Definition
| Can - immunoflourescent staining. Can't - ELISA |
|
|
Term
| How is genital herpes tx? |
|
Definition
| Acyclovir OR Famciclovir OR Valacyclovir |
|
|
Term
| 3 complications of genital HSV infections? |
|
Definition
| Aseptic meningitis, 2nd bacterial infxn, recurrence |
|
|
Term
| Which complication is more common in primary rather than recurrent infxn of genital HSV? |
|
Definition
|
|
Term
| What is the 2nd most common cause of genital ulcer dz worldwide? |
|
Definition
|
|
Term
| Describe the ulceration in primary syphilis. |
|
Definition
| painless chancre, highly infectious |
|
|
Term
| When does secondary syphilis occur? What does it represent? |
|
Definition
| 2-8 wks after chancre dev. Hematogenous dissemination of spirochetes. |
|
|
Term
| What are the clinical findings in secondary syphilis? (6) |
|
Definition
| Whole body rash, gen. lymphadenopathy, malaise, alopecia, mucous patches, condylomata lata |
|
|
Term
| What is condylomata lata? |
|
Definition
| Highly infectious patches of weepy pink or gray skin that appear in the moist areas of the body during secondary syphilis. |
|
|
Term
|
Definition
| Benzathinine Penicillin G |
|
|
Term
| Tx for syphilis w/ a penicillin allergy? |
|
Definition
|
|
Term
| Tx for neurosyphilis? If allergy present? |
|
Definition
| IV aqueous crystalline penicillin G. Ceftriaxone. |
|
|
Term
| Etiologic agent of Chancroid? |
|
Definition
|
|
Term
| Clinical presentation of chancroid? |
|
Definition
| Painful genital lesions, painful lymphadenopathy |
|
|
Term
| What is seen on gram stain of Chancroid? |
|
Definition
| "school of fish" appearance |
|
|
Term
|
Definition
|
|
Term
| Etiologic agent of granuloma inguinale (donovanosis)? |
|
Definition
| Calymmatobacterium granulomatus |
|
|
Term
| Clinical presentation of granuloma inguinale? |
|
Definition
| Painless, ulcerative lesions w/ beefy red appearance that bleed easily on contact, no lymphadenopathy |
|
|
Term
| What is seen on darkfield microscopy of granuloma inguinale? |
|
Definition
| Donovan bodies (safety-pin shaped intracytoplasmic inclusion bodies) |
|
|
Term
| Tx of granuloma inguinale? |
|
Definition
|
|
Term
| etiologic agent of lymphogranuloma venereum? |
|
Definition
| Chlamydia trachomatis serotypes L1, L2, or L3 |
|
|
Term
| What is the most common clinical presentation of lymphogranuloma venereum? |
|
Definition
| unilateral, tender, inguinal and/or femoral lymphadenopathy |
|
|
Term
| Tx of lymphogranuloma venereum? |
|
Definition
|
|
Term
| What genotype of HPV cause condyloma acuminatum (anogenital warts) |
|
Definition
|
|
Term
| What genotypes of HPV cause cervical infxn/neoplasia? |
|
Definition
|
|
Term
| How is HPV transmitted? What is the infxn rate of a single contact? |
|
Definition
|
|
Term
| What are 2 patient-applied tx for genital warts? |
|
Definition
|
|
Term
| Name 4 provider-administered tx for HPV. |
|
Definition
| 1) Cryotherapy 2) Podophyllin resin 3) Trichloroacetic or Bochloroacetic acid 4) Surgical excision |
|
|
Term
| Name 4 situations in which HPV lesions are resistant to tx? |
|
Definition
| 1) Pregnancy 2) DM 3) Smokers 4) Immunosuppressed |
|
|
Term
| What type of CA is associated with HPV? |
|
Definition
| squamous cell cervical CA |
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