Term
| define agammaglobulinemias |
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Definition
| deficiences in the b cell system with lowered to no ab production |
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Term
| why are defects in cellular immunity more difficult to manage than humoral immunity? |
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Definition
| bcell injections can be given to pt, tcells cant due to the rxns they cn cause |
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Term
| what is affected in digeorge anomaly |
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Definition
| developing thymus in a fetus -causing lowered tcell production |
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Term
| what is the most severe combined cellular and humoral deficiency; give treatments for this disease |
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Definition
| SCID; BM/stem cells transplant & ada enzyme treatment |
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Term
| why are malignanciesof b cells often associated with excessive ab production |
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Definition
| bc each single plasma cell only secretes one type of ab, malignancies will present a lrg amt of that ab |
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Term
| name 2 plasma cell syndromes |
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Definition
| mult myeloma & waldenstroms macroglobulinemia |
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Term
| describe the typical mult myeloma sufferer |
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Definition
| black male, 40-70, bone pain |
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Term
| give 4 typical hematologic findings in a mult my pt |
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Definition
| anemia, thrombocytopenia, rouleaux, neutropenia |
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Term
| mult my has a monoclonal or polyclonal abnormality |
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Definition
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Term
| cryoglobulins are linked to what disease? how are they detected in the lab? |
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Definition
| waldenstroms; refridgerating sample will cause then to precipitate out and the precipitate formed will dissolve upon warming |
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Term
| list initial tests used to screen for monoclonal abnormalities (2) |
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Definition
| serum ig levels and serum protein electrophoresis |
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Term
| what additional tests are run if screening tests indicate a monoclonal gammopathy |
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Definition
| immunoelectrophoresis, immunofixation electrophoresis, FISH testing |
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