Term
| the affinity of a antibody for a specific antigen depends upon ? |
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Definition
| complimentary shape and property of the antigen binding site to the antigen |
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Term
| which function below can be assigned to antibodies? |
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Definition
| neutralization, complement activation, antigen binding, opsonization |
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Term
| which of the following statements concerning antigen and epitopes are true? |
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Definition
epitopes include a linear pathogenic peptide sequence or amino acid from different part of the antigen,
a protein molecule or viral capsid protein may contain multiple epitopes,
not all antigen are capable of eliciting an immune response |
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Term
| neutralization, opsonization, activation of complement are all functions of which antibody? |
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Definition
|
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Term
| what do the different antibody isotypes, generated in response to a specific antigen have in common? |
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Definition
| they all have the same antigen specificity |
|
|
Term
| which of the molecules listed below play an essential role in antigen presentation? |
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Definition
|
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Term
| which of the following immunoglobulin isotypes is the first to be produced in an immune response to a given antigen? |
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Definition
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Term
| in a normal person, what percentage of the total serum Ig is IgG? |
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Definition
|
|
Term
| what structural element of an antibody is MOST important for antigen binding specificity? |
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Definition
| Complementary determinant region |
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|
Term
| which of the following statesments about IgM is true? |
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Definition
| It is important in the first few days of the primary immune response |
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|
Term
| which of the following immunoglobulins protects the mucosal surfaces of the respiratory , intestinal and genourinary tract from pathogenic organisms ? |
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Definition
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|
Term
| the primary purpose of the adaptive immune response is to: |
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Definition
| protect from disease upon re-infection from an specific antigen |
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|
Term
| the primary purpose of the adaptive immune response is to: |
|
Definition
| protect from disease upon re-infection from an specific antigen |
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Term
| a vaccine administered in the autumn of one year may protect against the prevalent strain of influenza that originated in hong kong that same year, but it will not protect against an;other strain that originated in russia. This phenomena illustrates which of the following property of the adaptive immune system? |
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Definition
|
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Term
| the body's first defense against infection involves the following: |
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Definition
| skin, Lysozyme , mucus, acidic enviroments |
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Term
| of the cells named below which of the following is specialized in the innate immune response? |
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Definition
|
|
Term
| rapid but not antigen specific responses are produced by |
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Definition
|
|
Term
| inflammation does not involve: |
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Definition
|
|
Term
| vaccination protects us from disease by generating : |
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Definition
|
|
Term
| what is a unique molecular components of the innate immune response |
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Definition
|
|
Term
| the interaction between an effector t-cell and a macrophages induce |
|
Definition
| activation of macrophages |
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Term
| a previously healthy 8 year old boy is infected with an upper respiratory tract virus of the first time. during the first few hours of the infection, which of the following events occur? |
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Definition
| the innate immune system responds rapidly to the viral infection and keeps the viral infection under control |
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|
Term
| the innate immune response involves the following |
|
Definition
rapid response,
limited number of specificity,
natural killer cells |
|
|
Term
| which of the following is true?(effector cells) |
|
Definition
| some effector cells of the immune system have innate and adaptive functions |
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Term
| which mechanism does NOT contribute to antibody-antigen binding diversity? |
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Definition
| many heavy chain Fc coding genes are present in the germline DNA |
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Term
| hematopeetic stem cells are pluripotent, which means they are? |
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Definition
| capable of developing into any blood cell |
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Term
| what statement below is true regarding isotype switching |
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Definition
| a process that results in the irreversible selection of sequences for the constant domains of the Fc portion of the antibody |
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|
Term
| combinatorial diversity says that by random combination of 40 functional Vk segments with 5 Jk segments, the number of different k chains that could be made are: |
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Definition
|
|
Term
| what mechanism is responsible for increasing antibody affinity to antigen after b-cell activation? |
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Definition
|
|
Term
| the ability of an antigen to induce an immune response does NOT depend on the antigen's: |
|
Definition
| ability to enter the bone marrow |
|
|
Term
| where are lymphocytes activated? |
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Definition
|
|
Term
| what is the name of the molecule that when covalently linked to a non-immunogenic antigen can make it immunogenic? |
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Definition
|
|
Term
| macrophages bind mannose on bacteria and phagocytose them |
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Definition
|
|
Term
| t-cells secrete il-4 to activate b-cell proliferation |
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Definition
|
|
Term
| an NK cell binds to IgG coated parasite and lyses it |
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Definition
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