Term
| Immune system major function is to eliminate... |
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Definition
| microbes, neoplasms, transplants |
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Term
| which immune system cells are found in the blood? |
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Definition
| neutrophils, and monocytes |
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Term
| Macrophages are found where? |
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Definition
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Term
| Cytokines are secreted by what? |
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Definition
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Term
| Where are B cells derived? what type of immune cell are these? |
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Definition
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Term
| The lymphocytes that are derived from the thymus are called what? |
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Definition
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Term
| what is the 1st immunogloblin release after exposure? |
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Definition
|
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Term
| what are the 3 broad types of lymphocytes |
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Definition
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Term
| Which is the only immunoglobulin to cross placenta? |
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Definition
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Term
| IgG increase in amount with the descrease of what? |
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Definition
|
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Term
| what are the most prevalent (esp memory response) if IG? |
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Definition
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Term
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Definition
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Term
| IgE is found where where and plays a major part in what? |
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Definition
| respiratory and GIT...allergies |
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Term
| how do T cells recognise Ag |
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Definition
| they dont have Ig but the recognise by recpetor and other adhesion molecules |
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Term
| Where are HLA loci found? (chromosomal) |
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Definition
|
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Term
| what are the 4 principle HLA loci? |
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Definition
| CLass 1, class 2, B cells, and T cells |
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Term
| B cells will rarely respond to soluble Ag, and generally recognise Ag when embedded with MHC... T or F |
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Definition
| F, b cells can recognise soluble Ag. it is the T cells which have the mentioned characteristics. The recognise Ag-MHC |
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Term
| what does class 2 MLA include? |
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Definition
| HLA-D Locus, HLA-DR Locus, HLA-DQ locus |
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Term
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Definition
| present antigens from outside of the cell to T-lymphocytes. These particular antigens stimulate T-helper cells to reproduce and these T-helper cells then stimulate antibody producing B-cells, self-antigens are suppressed by suppressor T-cells |
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Term
| the capacility to mount a humoral response is determined by what? |
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Definition
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Term
|
Definition
- T cell recognition of AG,
- capacity of phagocytes to present Ag
- B cell potential to produce Ab
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Term
| decreased control of humoural immune responce will resil in what? |
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Definition
| un regulated Ab production leading to self destruction |
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Term
| where is the imcompatability in Rhesus incompatibility |
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Definition
|
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Term
| what is the rhesus status of mother and child in rhesus compatability? |
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Definition
| mother Rh-ve (dd) and she is carrying a Rh+ve foetus (Dd or DD) |
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Term
| how do you prevent complications of Rh incompatability? |
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Definition
| give mother Rh immunoglobin at times of bleeding during pregnancy... |
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Term
| how is extent of haemolyis assessed in Rh incompatability |
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Definition
| amniocentesis, fetal Hb, US |
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Term
| Spleen is major site of Ab synthesis? T F |
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Definition
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Term
| The major phagocytic organ is the liver, T F |
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Definition
|
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Term
| removing the spleen is one way of decreasing the risk of overwelming bacterial infectiosn because the cell mediated immunity is not trigger now...T F |
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Definition
| false, that was gibberish and the a splenectomy will increase the risk of overwelming bacterial infections because it is very important in Ab synthesis and phagocytosis |
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Term
| which is more common primary or secondary immunodeficiency? |
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Definition
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Term
| whtare are some causes of impaired immune system in a previously normal individual? |
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Definition
| Metabolic Dz, immunosuppression, infection, haematological Dz, surgery/trauma |
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Term
| what are 2 traumatic causes of secondayr immunodeficiency |
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Definition
|
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Term
| 3 metabolic causes of immunodeficiency |
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Definition
| DM, malnutrition, Vitamin/mineral deficiency |
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Term
| primary deficiencies of the immuno system are caused by traumtic damage to necessary organs, and are not acquired as an an=utoimmune reponse T or F |
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Definition
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|
Term
| 4 groups of primary immunodeficiency are |
|
Definition
| B cell: infections
T cell: Viral
Phagocytic
Complement disorders: causing SLE or infections such as neisseria |
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Term
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Definition
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Term
|
Definition
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Term
| the Ag-Ab reaction in type 1 hypersensitivity causes what? |
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Definition
| release of potent vasoactive and inflammatory mediators (eg histamine) leading to vasodilation and increase capillary permeability |
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Term
| Atopic diseases range from what? |
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Definition
- allergic rhinitis
- conjunctivitis
- asthma
- atopic dermatitis
- systemic anaphylaxis
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Term
| which immunohglobin is implicated in type 1 hypersensitivity |
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Definition
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Term
| hives are called what medically, and what do they involve? |
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Definition
| urticaria, type 1 hypersensitivity, with a local wheal and erthema in dermis |
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Term
|
Definition
| large odematous areas, associated wiht diffuse swelling of loose connective tissue |
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Term
| common places of angioodema |
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Definition
| dorsum of hands, eyelids, lips, genitals, mucous membranes |
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Term
| what is a problem with angiooedema? |
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Definition
| can cause respiratory distress |
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Term
| what is the Rx of a food allergy? |
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Definition
| avoidance, desensitisation, anti-histamines |
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Term
| Pernicious anaemia is caused by what type of hypersensitivity reacton? |
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Definition
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Term
| a cytotoxic, reaction from Ab acting with antigenic cellular components is characteristic fo what hypersentivity |
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Definition
|
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Term
| what are 3 disorders of Type III hypersensitivity |
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Definition
| acute glomeronephritis, RA, Serum sickness |
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Term
| Type II hypersensitivy is caused what |
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Definition
| antibody dependent cytotoxic |
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Term
| In type III hypersensitivity.... Ab-AG complex activitate complement, this activites (what???) leading to acute inflammation |
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Definition
| release of vasoactive substances,which stimulate and activate PMN and other phagocytyes leading to |
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Term
|
Definition
| Polymorphonuclear Leucocytes |
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Term
| Complex mediated hypersensitivity is what type of hypersensitivity |
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Definition
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Term
| Type Iv hypersensitivity is called what, and mediated byb wwhat? |
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Definition
| Cell mediated (delayed type) hypersensitivity.... mediated by sensitised T cells |
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Term
| contact dermatitis is what type of hypersensitivity? |
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Definition
|
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Term
| whatre are 4 example of an autoimmune disorder? |
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Definition
Hashimotos thyroiditis
SLE, Good pasture disease, graves disease |
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Term
|
Definition
| antinuclear Ab, Anti DNA ab |
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|
Term
| goodpastures is a disorder, what ab? |
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Definition
| anti basement membrane Ab |
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Term
| goodpastures is characterised by what? |
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Definition
| rapid destruction of kidneys and lung haemorrage |
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