Term
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Definition
Pyrogen (fever, acute inflammation)
Activates endothelium to express adhesion molecules
Induces chemokine secretion to recruit leukocytes |
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Term
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Definition
| Stimulates growth of helper, cytotoxic and regulatory T cells |
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Term
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Definition
Stimulates bone marrow to grow and differentiate.
Functions like GM-CSF |
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Term
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Definition
Induces differentiation into Th2 cells
Promotes growth of B cells
Enhances class switching to IgE and IgG |
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Term
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Definition
Promotes differentiation of B cells
Enhances class switching to IgA
Stimulates growth and differentiation of eosinophils |
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Term
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Definition
Pyrogen (fever and induction of acute-phase proteins)
Secreted by Th2 cells |
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Term
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Definition
| Chemotactic factor for PMNs |
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Term
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Definition
Induces differentiation of T cells into Th1 cells
Activates NK cells
Secreted by B cells |
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Term
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Definition
Mediates septic shock
Activates endothelium
Causes leukocyte recruitment, vascular leak |
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Term
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Definition
Activates macrophages and Th1 cells
Suppresses Th2 cells
Antiviral and antitumor properties
Increases MHC I and II expression and antigen presentation in all cells
Activates NK cells to kill virus infected cells |
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Term
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Definition
Modulates inflammatory response
Inhibits actions of activated T cells and Th1
Secreted by regulatory T cells |
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Term
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Definition
| Modulates inflammatory respose |
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Term
| Interferon alpha and beta |
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Definition
| Inhibit viral protein synthesis by inducing production of ribonuclease that degrades viral mRNA |
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Term
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Definition
Common: TCR, CD3, CD28 (binds B7 on APC)
Unique: CD4, CD40 ligand |
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Term
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Definition
Common: TCR, CD3, CD28
Unique: CD8 |
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Term
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Definition
Ig (binds antigen)
CD19, CD20, CD21 (EBV receptor), CD40, MHC II |
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Term
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Definition
| CD14, CD40, MHC II, B7, Fc ad C3b receptors |
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Term
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Definition
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Term
|
Definition
IL-8
n-formylated peptides
leukotriene B4
%-HETE
C5a of complement |
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Term
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Definition
| CD3, CD4, CD25 (IL-2 receptor) |
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Term
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Definition
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Term
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Definition
| Psoriasis, Ankylosing Spondylitis, Inflammatory bowel disease, Reiter's syndrome (reactive arthritis) |
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Term
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Definition
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Term
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Definition
| Multiple sclerosis, hay fever, SLE, Goodpasture's |
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Term
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Definition
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Term
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Definition
| Rheumatoid arthritis, diabetes mellitus type I |
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Term
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Definition
| Pernicious anemia --> B12 deficiency, Hashimoto's thyroiditis |
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Term
| Antinuclear antibodies (ANA) |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Rheumatoid factor, anti-CCP |
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Definition
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Term
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Definition
| Scleroderma (CREST syndrome) |
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Term
| Anti-Scl-70 (anti-DNA topoisomerase I) |
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Definition
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Term
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Definition
| Primary biliary cirrhosis |
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Term
| IgA antiendomysial, IgA anti-tissue transglutaminase |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Antimicrosomal, antithyroglobulin |
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Definition
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Term
| Anti-Jo-1, anti-SRP, anti-Mi-2 |
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Definition
| Polymyositis, dermatomyositis |
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Term
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Definition
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Term
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Definition
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Term
| Anti-U1 RNP (ribonucleoprotein) |
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Definition
| Mixed connective tissue disease |
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Term
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Definition
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Term
| Anti-glutamate decarboxylase |
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Definition
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Term
|
Definition
| Granulomatosis and polyangiitis (Wegener's) |
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Term
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Definition
| Microscopic polyangiitis, Churg-Strauss syndrome |
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Term
| Anaphylaxis (type of hypersensitivity) |
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Definition
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Term
| Rhinitis (type of hypersensitivity) |
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Definition
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Term
| Hay fever (type of hypersensitivity) |
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Definition
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Term
| Eczema (type of hypersensitivity) |
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Definition
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Term
| Hives (type of hypersensitivity) |
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Definition
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Term
| Asthma (type of hypersensitivity) |
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Definition
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Term
| Autoimmune hemolytic anemia (type of hypersensitivity) |
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Definition
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Term
| Pernicious anemia (type of hypersensitivity) |
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Definition
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Term
| Idiopathic thrombocytopenic purpura (type of hypersensitivity) |
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Definition
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Term
| Erythroblastosis fetalis (type of hypersensitivity) |
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Definition
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Term
| Acute hemolytic transfusion reaction (type of hypersensitivity) |
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Definition
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Term
| Rheumatic fever (type of hypersensitivity) |
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Definition
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Term
| Goodpasture's syndrome (type of hypersensitivity) |
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Definition
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Term
| Bullous pemphigoid (type of hypersensitivity) |
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Definition
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Term
| Pemphigus vulgaris (type of hypersensitivity) |
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Definition
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Term
| SLE (type of hypersensitivity) |
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Definition
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Term
| Polyarteritis nodosa (type of hypersensitivity) |
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Definition
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Term
| Poststreptococcal glomerulonephritis (type of hypersensitivity) |
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Definition
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Term
| Serum sickness (type of hypersensitivity) |
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Definition
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Term
| Arthus reaction following tetanus vaccine (type of hypersensitivity) |
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Definition
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Term
| Multiple sclerosis (type of hypersensitivity) |
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Definition
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Term
| Guillain Barre (type of hypersensitivity) |
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Definition
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Term
| Graft versus host disease (type of hypersensitivity) |
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Definition
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Term
| PPD (type of hypersensitivity) |
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Definition
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Term
| Contact dermatitis (type of hypersensitivity) |
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Definition
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Term
| Febrile non-hemolytic transfusion reaction (type of hypersensitivity) |
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Definition
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