Term
| ________________contain many proteins and glycolipids capable of evoking antibody formation |
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Definition
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Term
| ABO blood group antigens are formed when transferases add specific sugars to the |
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Definition
| ends of carbohydrate chains called oligosaccharides |
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Term
| Genes at three separate loci control the occurrence and location of |
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Definition
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Term
| There are between ______and ________ antigens on an RBC |
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Definition
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Term
| Antigens are ___________and ___________, that produce an antibody response. |
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Definition
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Term
| ___________determined about 6 mo before antibody develops |
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Definition
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Term
| links of different sugars determine_____________. |
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Definition
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Term
| group O has the ______antigen |
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Definition
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Term
| Group A has a different sugar added to the ___________of the chain |
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Definition
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Term
| Type ________has a different sugar on the terminal end |
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Definition
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Term
| cis-AB has a, b, and _________antigens |
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Definition
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Term
| type A has ________antibody |
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Definition
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Term
| type B has ____________antibody |
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Definition
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Term
| Type AB has what antibodies? |
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Definition
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Term
| Type _________has Anti-A and Anti-B antibodies |
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Definition
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Term
| Bombay phenotype is recessive for _______antigen, but they don't express it. |
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Definition
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Term
| The ultimate blood doner is____________.Not the universal blood donor. |
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Definition
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Term
| 80% of people are secretors, they secrete ____________in various body fluids. |
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Definition
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Term
| A subgroup of an antigen has a variation of ____________ in chain. The initial backbone is different. |
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Definition
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Term
The A (sub 2) antigen has a _________
linkage |
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Definition
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Term
The A(sub 1) antigen has a _________ linkage between galactose and
N-acetylglucosamine |
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Definition
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Term
| A2 antigen may produce a_______antibody |
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Definition
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Term
| One inherits a d,c, or e antigen from______________. |
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Definition
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Term
| About 80% of the population, have a D antigen, this means they are________ |
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Definition
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Term
| Do we worry about women or men developing an anti-D antigen |
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Definition
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Term
| Rh antibodies develop only after_________________ |
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Definition
| immune sensitization or exposure |
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Term
| The anti- D antigen will attack an newborns__________, resulting in Hemolytic disease of the Newborn. |
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Definition
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Term
| Rh antibodies, when produced are primarily __________and readily cross the placenta |
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Definition
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Term
| 33% of caucasion have the __________ Rh genotype.They are Rh positive. |
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Definition
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Term
| what is looked at when blood typing |
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Definition
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Term
| _____screens for unexpected antibodies |
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Definition
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Term
| transfusion or any___________can cause antibodies to form |
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Definition
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Term
| what type of patients should a type and screen be done for |
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Definition
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Term
| In surgical patients, whether or not to have blood typed and crossed depends on __________________________. |
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Definition
| the type of procedure and the anticipated blood loss |
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Term
| a patient may have reaction to donor blood either ______---or_____________ |
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Definition
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Term
| when transfusing blood, always match_________first |
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Definition
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Term
| before exposing a patient to the anti-D antigen, what should you ask yourself/ |
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Definition
| Is it a female of childbearing age? |
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Term
Plasma is opposite of RBCs, ____does not have anti-A or anti-B,
O plasma has _____and _________. |
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Definition
AB plasma ;
anti-A and anti-B |
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Term
| Rh is NOT a factor when transfusing which blood product? |
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Definition
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Term
| Liver, spleen, kidneys will react first if give ________________. |
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Definition
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Term
| Anti Human Globulin (AHG) is looking |
|
Definition
| antibody on the surface of RBC |
|
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Term
| complement can cause cell_-- |
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Definition
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Term
| DAT is used to detect_____________ |
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Definition
| coating of the red cells by antibodies In vivo. |
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Term
AHG should bind to antibodies if they are there and have ___________
Patient will be antigen + for that particular antibody |
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Definition
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Term
| If a reaction from blood is suspected, monitor______________ in patient |
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Definition
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Term
| blood can be ___________to remove anything excess |
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Definition
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Term
| The more ________ present, the more difficult to find a donor |
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Definition
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Term
| If Pt serum reacted with donated RBCs-look for ________, then identify the antigen |
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Definition
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|
Term
| ____-blood is rarely given |
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Definition
|
|
Term
| packed red cell are mostly given when there is a need to get __________ in |
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Definition
|
|
Term
| platelet concentrates are used for__________ |
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Definition
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|
Term
_____________ Used for dilutional coagulopathies, when RBCs are given frequently.
Should give 4:1 ratio. |
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Definition
|
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Term
|
Definition
| all coagulation factors and other proteins |
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Term
| Cryoprecipitaed Antihemophylic Factor (CRYO) |
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Definition
| Freeze plasma, factor 8 will precipitate out-given for Hemophilia A |
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Term
|
Definition
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Term
|
Definition
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Term
| Gamma irradiation___________white cells |
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Definition
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Term
| Acute Hemolytic Transfusion Reaction (HTR) usua due to _____________. First clue-pain at infusion site |
|
Definition
| ABO incompatibility (unit labeled wrong, read wrong, etc) |
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|
Term
| Febrile non-hemolytic reaction does not affect_____________. First symptom is____________. |
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Definition
|
|
Term
| uticarial(skin) may be due to _______________ |
|
Definition
| may be due to plasma proteins |
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|
Term
| Anaphylactic reactions are very rate with blood products and usually involve__________ |
|
Definition
|
|
Term
_____________ is Not an acute reaction and may
Take days or weeks to develop |
|
Definition
| Delayed hemolytic Transfusion reaction |
|
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Term
|
Definition
|
|
Term
| how long does primary HTR take to develop? characterized by what? |
|
Definition
may take weeks;
low hemoglobin and Malaise, fever, RBC in urine |
|
|
Term
| Why would a previously immunized individual have an anamnestic response? |
|
Definition
| The renewed antigenic stimulation in a person already primed by previous antigenic exposure results in recrudescence of antibody to levels that can cause hemolysis |
|
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Term
| to prevent GVHD, you could use |
|
Definition
|
|
Term
| Posttransfusion Purpura is rare and develops when |
|
Definition
| a multiparous femaledevelops antibodies to platelets |
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Term
| in case of reaction, the following should be done: |
|
Definition
Document temp, HR, etc.!
Check blood, labels, etc. to make sure wrong unit, type!
Everything should be sent back-tubing and all! |
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Term
|
Definition
Rh neg Moms, having a Rh+ baby, Mom makes antibody that’s attacking baby.
Oxygen in blood decreases, HR increases. |
|
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Term
| Ectopic pregnancy-O neg Mom with Anti-D . what should be advised |
|
Definition
| shouldn't get pregnant again |
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Term
| Rogan (Anti_D) given at week 28 – Why at this point in time? |
|
Definition
| half life will carry thru to end of term |
|
|
Term
| amount of bilirubin that is detrimental to baby? |
|
Definition
|
|
Term
| Why is unconjugated bilirubin insoluble? |
|
Definition
| (insoluble-bound by albumin, cannont be excreted and accumulates in tissue) |
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|
Term
| What does Rhogam do when used for HDN? |
|
Definition
Gives passive immunity before mom’s system can invoke an immune response
Given for all Rh negative women |
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