Term
| Understand the unique components of the immune system that interact with tumors |
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Definition
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Term
| ID the mechanisms that lead to tumor escape from the immune system |
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Definition
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Term
| understand the basis for immunotherapeutic approaches currently in use of under clinical investigation |
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Definition
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Term
| what is the main cell used to kill tumor cells? |
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Definition
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Term
| what cells in the body do NOT express MHC class I? |
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Definition
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Term
| what are two types of receptors on NK cells? |
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Definition
| inhibitory and activating receptors |
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Term
| what does MHC class I block (or down regulate) on the cell surface of the NK cell? |
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Definition
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Term
| what two major categories of antigens are recognized by tumor infiltrating T cells? |
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Definition
| tumor associated antigens & tumor specific antigens |
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Term
| what are two basic protein classes of tumor associated antigens? |
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Definition
| Differentiation (ex: melanocyte antigens) and Developmental (not normally expressed in adult) |
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Term
| what are two protein classes of tumor specific antigens? |
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Definition
| Mutated (any protein) and Virus oncogenes (like HPV) |
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Term
| how do tumors progress in the presence of an immune response? |
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Definition
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Term
| what are some ways tumors evade the immune system? |
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Definition
| Failure to produce tumor antigen. Lack of expression of MHC class I on the tumor cell. These both lead to Lack of T cell recognition of tumor. Lastly, tumors will produce immunosuppressive proteins that inhibit T cell activation |
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Term
| what is the tumor stroma? |
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Definition
| the other cell types that potentially block the access of the immune system to access the tumor cells |
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Term
| what is the second tumor evasion mechanism? |
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Definition
| problems with effector cells (T and K) |
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Term
| what happens during the induction of T cell tolerance? |
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Definition
| they are not co-stimulated so they get deleted or become anergic |
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Term
| what is the 3rd way a tumor can evade the immune system? |
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Definition
| active suppression by regulatory cells |
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Term
| what is Cancer ImmunoEditing |
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Definition
| Elimination, equilibrium, escape |
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Term
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Definition
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Term
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Definition
| induced within host, durable |
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Term
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Definition
| induced outside host, can be durable |
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Term
| combination immunotherapy |
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Definition
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Term
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Definition
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Term
| what does HER2 stand for? |
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Definition
| Human Epidermal Growth Factor |
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Term
| he went on to talk about each mode of therapy in more detail |
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Definition
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Term
| if you can target tumor-specific antigens, will you end up with specific immunity or autoimmunity? |
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Definition
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Term
| if you can target tumor-associated antigens, will you end up with specific immunity or autoimmunity? |
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Definition
| autoimmunity (dont want this, its bad) |
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