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Definition
| blocks the activation of T cells by inihibiting calcineurin. preventing the production of IL-2 and it's receptor. Clinical use: organ rejection , and a few auto immune disorder. TX: viral infections and lymphoma at risk for. nephrotoxic, preventible with mannitol diuresis. |
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| similar to cyclosporine, binds to FK-binding porteins, inhibiting secretion of IL-2, and other cytokines. organ transoplant receptors. Tx- significant nephrotoxicity, peripheral neuropathy, hypertension, plerual effusion, hyperglycemia |
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| mech: antimetabolite precrusor of 6-mercaptopurine that interferes with the metabolism and syntehsis of neucleic acids. tx to proliferating lymphocytes. clnical use: kidney transplantation, auto immune disorders. including glomeronephrritis and hemolytic anemia (both are type II). tx: bone marrow supression. active metabolite is metablized by xanthine oxidase which is inhibited by allpurinaol so allourinol makes tx worse. |
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| muromonab. monoclonal antibody that binds to CD3 (episolon chain on t cells. blcoks cellular interaction taht lets T cells divide. Clinicl use: kidney transplant. tx- cytokine release syndrome (give tyelenol) allergy |
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Definition
| binds to mTOR inhibits T cell proliferation in response to IL-2. immuno supression after kidney transplant in combo with cyclosporine and corticosteroids. tx- hyperlipidemia, htombocyto penia and leukopenia |
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Definition
| mech: inhibits de notvo guanine synth and blocks lympthoctye production |
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Definition
| monoclonal antibody with high affinity for Il-2 receptors on activated immue T cells |
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| renal cell carcinoma, metastatic melanoma. makes em feel like crap |
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| granulocyte macrophage colony stimulating facotr recovery of bone marrow after chemo |
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Definition
| Hepatitis b, c kaposi's sarcoma (hhv2) leukemias, melanoma |
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Definition
| multiple sclerosis (type IV hypersenstivity) |
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| lack of production of Ifn-y and lack of response of neutrophils to chemotactic agents. leads to bacterial infections. FACIES. cold staph abscesses. retained primary teeth. IGE, dermatologic problems |
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| no igm production, causes up reg of iga and ige: WIPE infections, thrombocytopnic purpura, and eczema. |
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| bkt gene problem, plenty of pro bs. not enough mature b's. x linked. shit hits fan at 6mos when moms crap runs out. lots of bacterial infections |
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| pemphigus vulgaris (some blistering thing) |
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Definition
| sjogrens syndrome. dry everthing, inflamed parotitds, aurthritis. |
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Definition
| mixed connective tissue disorder |
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| multiple sclerosis, hay fever, sle good pastures |
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| pernicious anemia, hashimotiots |
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| steroid responsive nephrotic syndrome. |
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