Term
| How is Chloramphenicol available? |
|
Definition
| IV only now. Used to have apthalmic but not anymore |
|
|
Term
| What are the side effects of Quinupristin/Dalfopristin? |
|
Definition
1. arthralgias/myalgies
2. superinfection-> colitis
3. hyperbilirubinemia
4. venous irritation
5. vancomycin resistant strains of E Faecium |
|
|
Term
| What Sx are associated with 5-HT syndrome? |
|
Definition
| restless, tremore, delirium, rigidity, myoclonus, hyperthermia, hyperreflexia, sweating, shivering, blunted senses, seizures, coma |
|
|
Term
| What's the longest you can use Linezolid? |
|
Definition
|
|
Term
| What is the leading offender that causes pseudomembranous colitis? |
|
Definition
C. Difficile
Treated by Clindamycin (cleocin) |
|
|
Term
|
Definition
inhibits translocation
immunomodulatory activity vs group A Strep w. PCN |
|
|
Term
| What organisms do you treat with Polymyxin B? |
|
Definition
|
|
Term
| POlymyxin B (side effects) |
|
Definition
1. Neuromuscular block (neurotoxic)
2. Nephrotoxic!
* so it's topical only |
|
|
Term
|
Definition
|
|
Term
| What is Neosporin made of? |
|
Definition
| Polymyxin B + gramcidin + neomycin |
|
|
Term
| What is Neosporin GU irrigant? |
|
Definition
| Polymyxin B + neomycin (instilled into bladder) |
|
|
Term
| What is Rifaximin used for? |
|
Definition
1. Travelers diarrhea from non-invasive E. coli
2. lower risk of hepatic encephalopathy in Pt's w. advance liver disease by lowering ammonia producing bacteria |
|
|
Term
| Mupirocin (Bactroban) ... mechanism? |
|
Definition
| Inihibit bacterial isoleucyl t-RNA synthetase |
|
|
Term
| What are two drugs used for treating IMPETIGO? |
|
Definition
1. Mupirocin (Bactroban)
2. Retapamulin (Altabax) |
|
|
Term
|
Definition
| block acceptor/donor sites of peptidyl transferase |
|
|
Term
| Nitrofurantoin (mechanism) |
|
Definition
Reduced by UT bac -> reactive intermediates that damage DNA, ribosomes, cell wall, etc...
Hard for organism to depend itself against non-specific mech |
|
|
Term
| Nitrofurantoin (side effects) |
|
Definition
1. Pulmonary reactions
2. Discolor urine |
|
|
Term
| Why isn't Daptomycin used for penumonia? |
|
Definition
| inactivated by pulmonary surfactant |
|
|
Term
|
Definition
1. Depolarizes cytoplasmic membrane
2. Inhibits DNA, RNA, Prot Synth |
|
|
Term
| Daptomycin (side effects) |
|
Definition
| Increases creatine kinase |
|
|
Term
|
Definition
| IV for life threatening Plasmodium falciparum |
|
|
Term
| What bugs are Rifampin useful against? |
|
Definition
|
|
Term
|
Definition
| inhibits DNA-dependent RNA polymerase |
|
|
Term
|
Definition
1. Red-orange urine, feces, excretions, etc
2. Rash, fever, nausea, vomiting
3. Jaundice (fatalities rare)
4. Hepatitis (rare if normal liver) |
|
|
Term
| What should you use for pediatric doses? |
|
Definition
|
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