Term
| What are the Somatotropic Hormones? |
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Definition
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Term
| What are the Glycoprotein hormones? |
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Definition
Thyrotropin (TSH)
Luteiniaing hormone (LH)
Follicle-stimulating hormone (FSH)
Placental chorionic gonadotropin (CG) |
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Term
| What are the Proopiomelanocortin derived hormones? |
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Definition
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Term
| What stimulates and inhibits Growth Hormone secretion? |
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Definition
GHRH - stimulates
Somatostatin - inhibits |
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Term
| What is the mechanism of Growth Hormone? |
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Definition
| stimulates liver and other tissues to release IGF-1 via tyrosine kinase |
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Term
| What are Anabolic and growth-promotng effects mediated through? |
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Definition
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Term
| What can a deficiency of GH cause? Excess? |
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Definition
deficiency -> pituitary dwarfism
excess -> gigantism, Acromegaly |
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Term
| How does glucose effect GH? |
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Definition
Hypoglycemia stimulates GH release
Hyperglycemia inhibits GH release |
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Term
| What is the Negative Feedback for GH? |
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Definition
GH -> (-)Hypothalamus -X-> GHRH
IGF-1 -> (-)Anterior Pituitary -X-> GH |
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Term
| What is the biggest producer of IGF-1? |
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Definition
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Term
| What are the Direct and Indirect actions of GH? |
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Definition
Direct:
Decrease insulin sensitivity
Increase lipolysis
Increase IGF-1
Increase protein syntesis
Increase epiphyseal growth
Indirect:
IGF-1 actions -> protein syntesis, epiphyseal growth |
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Term
| What Endocrine drug is the same as human GH? |
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Definition
| Somatropin (Serstim, Genotropin, Humatrope) |
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Term
| What side effects are there in children and adults using GH? |
|
Definition
Children:
leukemia, increase ICP, nausea
Adults:
carpal tunnel, peripheral edema, arthralgia, myalgia |
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Term
| What can excess IGF-1 cause? |
|
Definition
|
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Term
| What are the Dopamine Receptor Agonists used for? |
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Definition
(Pergolide and Cabergoline)
Increase Dopamine -> Decreases prolactin -> Treat hyperprolactinemia from pituitary adenomas |
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Term
| What Dopamine Receptor agonist is primarly used to treat parkinson's? |
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Definition
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Term
| Which Dopamine Receptor Agonist has a higher affinity for D2 receptors and a longer half life? |
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Definition
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Term
| What is the Somatostatin Analog? |
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Definition
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Term
| What Somatostatin analog has a short half life and requires 3 x daily injections? |
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Definition
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Term
| What Endocrine drug is urine form post-menopausal women and contains FSH and LH? |
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Definition
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Term
| What is Menotropin used to treat, how is it administered? |
|
Definition
| Treat Female infertility Give IM |
|
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Term
| What are patients at risk for if they use gonadotropins? |
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Definition
|
|
Term
| What is Oxytocin used for? |
|
Definition
| Facilitating birth, Breast feeding |
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Term
| What does GnRH stimulate? |
|
Definition
| Stimulates FSH and LH release -> stimulate gonads Necessary for fertility |
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Term
| What type of Synthetic GnRH is used to Diagnose pituitary vs. hypothalamic defect if a pt has hypogonadotropism? |
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Definition
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Term
| What should be tried first with male infertility before turning to Lutrepulse? |
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Definition
|
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Term
| What analogue of GnRH is used to treat prostate cancer? |
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Definition
|
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Term
| How do the GnRH analogues work to treat prostate cancer? |
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Definition
(Leuprolide)
Initially increases LH production, then decreases LH and testosterone dramatically due to receptor down regulation |
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Term
| What Endocrine drugs can be used to treat uterine fibroids? |
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Definition
Leuprolide
(Decreases estrogen - estrogen simulates growth) |
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Term
| What is the GnRH Antagonist? |
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Definition
|
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Term
| What drugs are used in in vitro fertilization? |
|
Definition
(GnRH Antagonists)
Ganirelix
Used to delay LH surge -> delay ovulation to allow collection of ova |
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Term
What drug is made from each of the following types or urine?
Post-menopausal woman
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Definition
Post-menopausal woman
Menotropin (LH, FSH, and hCG)
Treat female infertility
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