Term
| Loop diuretics are most likely used in what? |
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Definition
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Term
| Are loop diuretics potent fluid depletors and if so, why? |
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Definition
Loops cause more sodium excretion and are thus more potent fluid depletors (greater water loss), which provide benefit in HF. |
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Term
| Are loop diuretics potassium depleting? |
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Definition
| Yes. They waste much more potassium than thiazides. |
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Term
| Do loop diuretics have an associated toxicity? |
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Definition
| Yes, ototoxicity (auditory damage/hearing loss) |
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Term
| What do loops normally require regarding supplements? |
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Definition
Loops usually require potassium supplements (potassium ext-release, or Klor - Clon). |
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Term
| Where do thiazides work in the body? |
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Definition
distal convoluted tubule of the nephron
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Term
| The long-term blood pressure lowering effect of thiazides is thought to be due to? |
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Definition
| vasodilation (decrease in resistance) |
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Term
| Where do loop diuretics work in the body? |
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Definition
ascending loop by blocking sodium reabsorption - this causes water to follow sodium into the urine, resulting in volume depletion |
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Term
| Are potassium-sparing diuretics effective (as thiazides and loops) and are they used as monotherapy for BP? |
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Definition
No. Potassium - sparing diuretics are not as effective and are not used as monotherapy for BP |
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Term
| potassium-sparing diuretics are normally in combo with what class of medication and why? |
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Definition
Potassium sparing diuretics are used in combo with hydrocholorothiazides (Maxzide/Dyazide) to counter thizide's mild potassium loss and help (a little) with BP
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Term
| The risk of using potassium - sparing diuretics? |
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Definition
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Term
Spironolactone and eplerenone and are used for HF (and HTN) - and increase potassium is a considerable risk with these agents. |
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Definition
| Statment. Not a question. |
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Term
| Name the generic names of thiazides? |
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Definition
Chlorothizide
Chlorthalidone
Hydrochlorothiazie
Indapamide
Metolazone |
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Term
| Brand name for chlorothiazide |
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Definition
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Term
| Brand name for chlorthalidone |
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Definition
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Term
| Brand name for Hydrochlorothiazide |
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Definition
| Microzide - capsule, Oretic |
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Term
| Brand name for Indapamide |
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Definition
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Term
| Brand name for Metolazone |
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Definition
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Term
| Do thiazides increase or decrease blood uric acid levels? |
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Definition
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Term
| Do thiazides increase or decrease lipids? |
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Definition
| Increase lipids (increase CH & TG) |
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Term
| Do thiazides increase or decrease blood sugar? |
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Definition
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Term
| Do thiazides increase or decrease calcium levels? |
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Definition
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Term
| Do thiazides increase or decrease sodium levels? |
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Definition
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Term
| Do thiazides inrease or decrease magnesium levels? |
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Definition
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Term
| Photosensitivity associated with thiazides? |
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Definition
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Term
| What type of allergy is associated with thiazides? |
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Definition
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Term
| Thiazides may not be as effective if CrCl < ___ ml/min |
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Definition
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Term
| Which thiazide is usefull in renal failure? |
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Definition
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Term
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Definition
| Statement. Not a question. |
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