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| understood the Islets of Langerhans are responsible for production of insulin |
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| first patient to receive insulin treatment |
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| noticed serum sickness in some patients who had been treated for pneumococcal infections; described hx of hypersensitivity |
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| maize just introduced from new world, found in poor residents of spain, noticed in asylum inmates, fixed by eggs and milk in diet |
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| "I cannot;" found in rice culture of SE asia; weakness and heart failure |
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| noticed chickens dev. polyneuritis when fed white rice; brown rice fixed it |
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| isolated active component of rice husks; named vitamine |
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| coined 'hormone;' discovered secretin |
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| separated NS into sym- and parasympathetic |
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| disc. ACh and showed that it produced the same inhibitory effects as stimulation of the nerves |
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| studies effects of shock during WWI; coined 'homeostasis' |
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| named serotonin (disc. by Erpsamer) |
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| devised method to synthetically produce progesterone from plants |
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| transferred poliovirus from spinal cord tissue of boy to monkey; same disease in each |
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| largest polio epidemic ever recorded - 9000 cases |
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| created immunization programs that caused several children to contract paralytic polio; severely criticized |
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| 1st polio vaccine from formalin inactivated virus - 100% protection |
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| hormone therapy; castration and female hormones improve prostate cancer |
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| 1st non hormonal chemotherapy - derivative of Mustard Gas |
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| folic acid antagonist (methotrexate) prevents chromosomal separation |
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| uses methotrexate (folic acid antagonist) in treating lung cancer secondary to choriocarcinoma (placental malignancy) |
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| discovers 1st infectious cancer cause; observes diet as affecting colon disease; his lymphoma common in Africa - endemic in tsetse fly belt - insect vector for Epstein Barr virus |
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| rabbits with damaged arteries had elevated LDL |
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| substituting veg fat for animal fat reduces cholesterol levels b/c unsaturated molecule |
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| created high fat and low carb diet, fidiot |
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| associated lung cancer with cigarette smoking; pub. controversial report on asbestos and lung disease |
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