Term
| This is the hallmark feature of essential hypertension |
|
Definition
|
|
Term
| what are the resistance vessels |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
THIAZIDE diuretics initially
ACE, ARB, BB, CCB |
|
|
Term
|
Definition
blocks Na reabsorption in kidney
Needs to be combined with another HTN drug. |
|
|
Term
|
Definition
| Enalapril, Fosinopril, Captopril |
|
|
Term
| Mech of Action for ACE inhibs |
|
Definition
| inhibits ACE which converts Ang I to ang II |
|
|
Term
| Clinical use of ACE inhibs |
|
Definition
| used alone or comb w/diuretic |
|
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Term
|
Definition
COUGH
hyperkalemia
angioedema
*increased renin*
NO to Pregant women! |
|
|
Term
|
Definition
|
|
Term
|
Definition
| bind receptors on sm. muscle, block Ang II from causing vasoconstriction |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Mech of action for aliskiren |
|
Definition
blocks angiotensinogen to ang I
*rate limiting step in formation of angII* |
|
|
Term
| Clinical use of renin inhib |
|
Definition
avoids rise in plasma renin activity
(renin thought to be involved in mortality0 |
|
|
Term
| HTN drug in pregnant women |
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Definition
|
|
Term
| where is the a1 receptor located |
|
Definition
| vascular smooth muscle (constriction) |
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|
Term
|
Definition
| CNS: inhibit NE to DECREASE sympathetic tone |
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|
Term
|
Definition
| In heart- incr rate, contractility, and CO |
|
|
Term
|
Definition
| vascular sm. muscle (dilation) |
|
|
Term
| What are the centrally acting sympatholytics |
|
Definition
| Clonidine, methyldopa, reserpine |
|
|
Term
| What are central acting used for |
|
Definition
|
|
Term
| Toxicities of Central acting |
|
Definition
CNS toxicity
dry mouth, stuffy nose
Methyldopa- *positive Coomb's test*
Clonidine- *severe rebound HTN* |
|
|
Term
| Peripheral acting sympatholytic |
|
Definition
|
|
Term
| Guanethidine mech of action |
|
Definition
No CNS effects
depletes catecholamine displacing them in peripheral nerve endings |
|
|
Term
|
Definition
severe sympatholysis
profound hypotension, shock |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Blocks a1 on vascular sm. muscle blocking constriction caused by NE release. |
|
|
Term
|
Definition
| 1st dose orthostatic hypotension and tachy |
|
|
Term
|
Definition
reduce HR and contr.
reduce renin release, decr Ang II |
|
|
Term
| Combination therapy of Beta blocker |
|
Definition
diuretic- uncomplicated HTN
also prevent reflex tachycardia |
|
|
Term
|
Definition
AV heart block
propanolol- bronchospasm |
|
|
Term
| This I.V. is available for HTN crisis, although not first line |
|
Definition
|
|
Term
| This direct vasodilator increases cGMP to cause smooth muscle relaxation |
|
Definition
|
|
Term
|
Definition
| lupus like syndrome of myalgia, arthalgia, and skin rashes |
|
|
Term
| Mech of action for Diazoxide |
|
Definition
| Activates K channels, hyperpolarizing vasc sm. muscle causing dilation |
|
|
Term
| Clinical use of Diazoxide |
|
Definition
|
|
Term
|
Definition
reflex tachycardia used alone
volume retention |
|
|
Term
| This direct vasodilator induces hyperglycemia |
|
Definition
|
|
Term
| This is a dopamine 1 agonist IV used for hypertensive ER |
|
Definition
|
|
Term
|
Definition
Verapimil
Diltiazem
Nifedipine and Amlodipine |
|
|
Term
|
Definition
| block L-type Ca channels affecting heart contraction and VSM |
|
|
Term
| Preference of CCBs in heart |
|
Definition
| verapimil, diltiazem, nifedipine |
|
|
Term
| preference of CCB in the vessels |
|
Definition
| Nifedipine, diltiazem, verapimil |
|
|
Term
|
Definition
Raynauds dz
Suprventricular arrhythmia |
|
|
Term
| Toxicity of Sodium Nitroprsside |
|
Definition
|
|
Term
| side effect of Fenoldapam |
|
Definition
| increase in intraocular pressure |
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