Term
| abundant with the skin, GI and respiratory tract |
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Definition
|
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Term
| histamine is synthesized by the enzyme________ |
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Definition
|
|
Term
| histamine is metabolized by |
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Definition
|
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Term
| what antibodies are on the surface of mast cells? |
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Definition
|
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Term
| what family do histamine receptors belong to? |
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Definition
| GPCRs - g protein coupled receptors |
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Term
| this histamine receptor is found in the bronchial smooth muscle, the vascular smooth muchle , vascular endothelium, cardiac tissue and CNS |
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Definition
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Term
| histamine receptors that are important in chemotaxis |
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Definition
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Term
| vascular effects of histamine |
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Definition
| dialation of small blood vessels via the H1 and H2 receptors & increased permeability of post capillary venules via H1 receptors |
|
|
Term
| cardiac effects of histamine |
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Definition
| increased iontropy via (h1 and H2 receptors), increased chronotropy (H2), decreased AV conduction (H1) |
|
|
Term
| Pulmonary effects of histamine: |
|
Definition
direct bronchoconstriction, increased mucous viscosity, cough (H1)
slight bronchodilation, increased mucous secretion H2 |
|
|
Term
| effects of histamine on the GI system |
|
Definition
| increased acid production (H2) |
|
|
Term
| neuronal effects of histamine |
|
Definition
cutaneous itching and pain (H1 and H2)
presynaptic inhibition of histamine synthesis and release (H3)
Regulation of DA, GABAm Ach, 5-Ht, and NE (H3) |
|
|
Term
| H1 receptor antagonists, h2 receptor antagonists, mast cell stabilizers |
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Definition
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|
Term
diphenhydramine (benadryl)
hydroxyzine
chlorpheniramine |
|
Definition
|
|
Term
cylizine
dimenhydrenate (dramamine)
meclizine |
|
Definition
| used primarily for motion sickness 1st gen |
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|
Term
|
Definition
| 1st gen anti-histamine used for nausea |
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|
Term
| reversible, competitive antagonist of the H1 receptor mildy anticholinergic (anti slude) |
|
Definition
| mechanism of action of the 1st gen H1 receptor antagonists |
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|
Term
| 1st gen H1 receptor antagonists will cross both the |
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Definition
|
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Term
| 1st gen H1 receptor antagonists will have additive effects with _______ |
|
Definition
| antimuscarinics and CNS depressants |
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|
Term
| first gen H1 receptor antagonists should be avoided with _____ |
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Definition
|
|
Term
acrivistine
cetirizine (zyrtec)
loratadine (claritin)
desloratadine
fexofenadine (allegra) |
|
Definition
| 2nd gen H1 receptor antagonists |
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|
Term
| useful as an antiallergy because they dont cross the BBB and cause sedation or anticholinergic effects |
|
Definition
| 2nd generation H1 receptor antagonists |
|
|
Term
| this 2nd gen H1 antagonist does have more cns actions than others and should not be taken by ppl who must be awake |
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Definition
|
|
Term
| these 2nd gen h1 antagonists are not metabolized |
|
Definition
| cetrazine, loratadine, fexofenadine |
|
|
Term
| cormolyn sodium nedocromil |
|
Definition
|
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