Term
| Which form of hepatitis is the leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma? |
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Definition
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Term
| What is the most common blood-born pathogen? |
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Definition
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|
Term
| What are the recommendation for HepC Virus screening? |
|
Definition
current of past IV drug use
coinfection with HIV
blood transfusion before 1992
clotting factors before 1987
ever on chronic hemodialysis
unexplained elevated ALT levels or evidence of liver disease
health care and public safety workers after an occupational exposure
children born to HCV-positive moms
immigrants from countries with high prevalence |
|
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Term
acute hep c infection becomes chronic in what % of pts?
what determines if it is chronic? |
|
Definition
up to 85%
persistently detectable HCV RNA for 6 months or more |
|
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Term
| What are contraindication to treatment of HCV? |
|
Definition
| autoimmune hepatitis, decompensated liver disease, women who are prego or whose female partner is prego, hemoglobinopathies, creatinine clearance <50mL/min, hemodialysis, ischemic CV or cerebrovascualr disease |
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Term
| What is the recommended treatment for genotype 1? |
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Definition
peginterferon alpha2a 180mcg/week OR
peginterferon alpha1.5mcg/week
PLUS Ribavirin dose for 48 weeks |
|
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Term
| What is the treatment for genotypes 1 and 2? |
|
Definition
peginterferon alpha2a 180mcg/week OR
peginterferon alpha1.5mcg/week
PLUS Ribavirin dose for 24 weeks
|
|
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Term
|
Definition
weight based:
<75kg 1,000mg
> 75kg 1,200mg
800mg (?) |
|
|
Term
When should you check the viral load for early virologic response in genotype 1 treatment?
when d you check with genotypes 2 and 3? |
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Definition
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|
Term
What is the brand name for pegylated interferon alpha 2a?
alpha 2b? |
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Definition
|
|
Term
| Which peglyated interferon has weight-dependent dosing? |
|
Definition
|
|
Term
| How are the pegylated interferon drugs administered? |
|
Definition
| subcutaneously once a week |
|
|
Term
| Which peglyated interferon is also indicated for treatment of hepatitis B? |
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Definition
|
|
Term
| What are common side effects of peginterferon? |
|
Definition
| fatigue, fever, HA, n, anorexia, rigors, myalgia, arthralgia, musculoskeletal p, insomnia, depression, anxiety, alopecia, inj site reaction |
|
|
Term
| what are the common side effects of ribavirin? |
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Definition
| fatigue, flu-like symptoms, neutropenia, thrombocytopenia, anemia |
|
|
Term
| What are ribavirin's brands? |
|
Definition
Copegus, Rebetol, RibaPak, Ribasphere, Virazole
|
|
|
Term
|
Definition
inhibits replication of RNA and DNA viruses
inhibits influenza virus RNA polymerase activity
inhibits the initation and elongation of RNA fragments resulting in inhibition of viral protein synthesis |
|
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Term
| What are some pt counseling tips for ribavirin? |
|
Definition
take capsules with food
if you are prego...step away
adequate hydration
increased susceptibility to inf
may cause dental or periodontal disorders
do not donate blood for 6mo following therapy (or ever with SCD)
if the man is taking the medication, it can still have teratogenic effects
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|
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Term
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Definition
alpha interferons are a family of proteins produced by nucleated cells that have antiviral, antiproliferative, and immune-regulating activity.
there are 16 known subtypes of alpha interferons
they interact with cells throguh high affinity cell surface receptors
following activation, multiple effects can be detected including induction of gene transcription
inh cellular growth, increases phagocytic activity of macrophages, and augments cytotoxicity of lympocytes for target cells |
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Term
| How do you measure for decompensated liver disease? |
|
Definition
|
|
Term
| How do you store Pegasys? |
|
Definition
|
|
Term
| What are the two types of HepA vaccines? |
|
Definition
|
|
Term
|
Definition
| when pre- or postexposure prophylaxis against infection is needed, it is most effective during incubation phase of infection at a single dose of 0.01mL/kg IM |
|
|
Term
| What are the stages of HepA? |
|
Definition
Incubation 28d
acute hepatitis 2mo
convalescence |
|
|
Term
| What is the incubation period for HepB? |
|
Definition
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