Term
| What is the term described as the growth and proliferation of one or more clones of abnormal cells? |
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Definition
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Term
| Myeloid:Erythroid (M:E) Ratio |
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Definition
Ratio of the number of mature and immature granulocytes to the number of mature and immature RBCs.
Normal range 2:1 to 4:1 in adults. |
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Term
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Definition
| New and abnormal formation of tissue such as a tumor or growth. |
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Term
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Definition
Malignant disease of hematopoietic tissue caused by the mutation of the bone marrow
Characterized by the replacement of normal bone marrow elements with abnormal (neoplastic) blood cells. |
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Term
| Leukemic cells can infiltrate which three organs? |
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Definition
| Spleen, Liver, and Lymph Nodes. |
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Term
| What is the difference between leukemia and lymphoma? |
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Definition
| In leukemia, abnormal cells are present in both the bone marrow and peripheral blood. In lymphoma, abnormal growth of cells is confined to the lymphatic tissue. |
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Term
| General Etiology of Leukemia |
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Definition
Exposure to ionizing radiation
Chemical agents
Viruses
Genetic Factors
Age
Race |
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Term
| What are chemical agents associated with leukemia? |
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Definition
Benzene and cytotoxic alkylating agents, i.e. chemotherapy drugs
Alkylating agents used to treat neoplasm |
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Term
| What viruses are associated with Leukemia? |
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Definition
Epstein-Barr virus ( a DNA virus)
Human T-cell Lymphotrophic Virus |
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Term
| Describe the genetic factors and their relation to the eitology of leukemia. |
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Definition
Leukemia does not appear to be inherited, however, tends to cluster in families (particularly childhood twins)
Increased in persons with congenital chromosomal abnormalities as in Down's Syndrome. |
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Term
| True or False? Age is clinically important in the diagnosis of leukemia. |
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Definition
| True, because different leukemias affect different age groups. |
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Term
| General symptoms of Leukemia |
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Definition
Splenomegaly, hepatomegaly, and enlargement of the lymph nodes.
Anemia and thrombocytopenia.
Infections, fever, weight loss, and malaise.
Death typically occurs due to infections and hemorrhages in the later acute and chronic stages. |
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Term
Acute vs Chronic leukemia
Age |
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Definition
Acute - all ages
Chronic - Adults |
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Term
Acute vs Chronic Leukemia
Onset |
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Definition
Accute - Sudden/Rapidly
Chronic - Symptoms of long duration |
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