Term
|
Definition
| degrades extracellular matrix |
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Term
|
Definition
| increases vascular permeability |
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Term
| Von Hippel-Lindau (HPL) E3 Ligase |
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Definition
| ubiquitylates HIF-1a for proteasomal degredation |
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Term
|
Definition
| trimerizes with HIF-B/p300 CBP to transcribe VEGF/EPO/PDGF-B/TGF-a |
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Term
|
Definition
| trimerizes with HIF-1a to transcribe VEGF/EPO |
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Term
|
Definition
| increases vessel permeability, high affinity for VEGF-A/B, low tyrosine kinase activity, autocrine VEGF receptor, intracrine for cell survival |
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Term
|
Definition
| high affinity binding for VEGFR1 |
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Term
|
Definition
| endothelial migration/proliferation/survival/permeability, low affinity for VEGF-A/C/D, high tyrosine kinase activity, not increased in hypoxia, controlled by Notch, neuropillin co-receptors |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| mediates lymphangiogenesis and tumor angiogenesis, binds VEGF-C/D, upregulated by Notch disruption, highly expressed in sprout cells |
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Term
|
Definition
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Term
|
Definition
| upstream of MAPK, constitutive form in cancer cannot hydrolyze GTP to inactive GDP form |
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Term
|
Definition
| stops the cell cycle, initiates DNA repair, induces apoptosis |
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Term
|
Definition
| phosphorylated to pass from G1 to S phase |
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Term
|
Definition
| translocated t(14;18) in follicular lymphoma |
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Term
|
Definition
| mutation at 5q21 causes colon cancer in teens, wild-type p53 keeps polyps benign, mutant p53 allows carcinoma |
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Term
|
Definition
| upstream activator of HIF-1a |
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Term
|
Definition
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Term
|
Definition
| expressed on tip cell, induces Notch internalization and processing to NICD |
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Term
|
Definition
| expressed on stalk cell, intreacts with DLL-4/Jagged-1, processed to NICD |
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Term
|
Definition
| processed form of Notch, transcripton factor for Hey |
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Term
|
Definition
| represses transcription of VEGFR2 and Hey |
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Term
|
Definition
| stimulates erythrogenesis and mobilizes erythroid progenitor cells (EPCs), signals MkEP to erythrocyte precursors |
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Term
|
Definition
| principle effector of K-ras |
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Term
|
Definition
| common mutation in colon cancer |
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Term
|
Definition
| colorectal cancer markers |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| indicators of response to breast cancer therapy |
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Term
|
Definition
|
|
Term
|
Definition
| 17q12 amplification detected by FISH in breast cancer |
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Term
|
Definition
| protein product detected by IHC in breast cancer |
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Term
|
Definition
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Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
| chimeric form of c-abl, increased tyrosine kinase activity |
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Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| SCF, IL-3, FL, G-CSF, GM-CSF |
|
Definition
|
|
Term
|
Definition
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|
Term
|
Definition
| HSC marker, loss causes differentiation to multipotent progenitors |
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Term
|
Definition
| early signals multipotent precursor to myeloid pathway, later signals MKEP to megakaryocyte precursors |
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Term
|
Definition
| signals multipotent precursors to lymphoid pathway |
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Term
|
Definition
| signals granulocyte precursors to eosinophil precursors |
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Term
|
Definition
| signals Tcell/NKcell precursors to NK cell proliferation |
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Term
|
Definition
| signals CMP to MkEP early, later signals granulocyte precurosrs to basophils/mast cells |
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Term
|
Definition
| signals granulcytic macrophage precursor proliferation, activates macrophages |
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Term
|
Definition
| signals neutrophil precurosr proliferation, activates neutrophils |
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Term
|
Definition
| signals monocyte precursor proliferation |
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Term
|
Definition
| activates survival and proliferation via Akt and Ras |
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Term
|
Definition
| primary transcription factor for GMPs (monocyte and neutrophil differentiation) |
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Term
|
Definition
| primary transcription factor of EMPS (erythrocyte and megakaryocyte differentiation) and CMPs (eosinophil differentiation), impairs PU,1 DNA transactivation/recruits deacetylase |
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Term
|
Definition
| transcription factor of GMP (neutrophils) and CMP (eosinophils) |
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Term
|
Definition
| transcription factor for GMP (monocytes) |
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Term
|
Definition
| transcription factor for CMP to EMP |
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Term
|
Definition
| transcription factor for EMP (megakaryocytes) |
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Term
|
Definition
| transcription factors for HSCs to CMP |
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Term
|
Definition
| inhibit EPO production in kidneys |
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Term
|
Definition
| transcription factor for CMP to GMP |
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Term
|
Definition
|
|
Term
|
Definition
| translocations repress hematopoiesis, common in myelogenous leukemia |
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Term
|
Definition
|
|
Term
|
Definition
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|
Term
|
Definition
| removes Fe2+ from cell, inhibited by hepcidin, stored in macrophage vessicles |
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Term
|
Definition
|
|
Term
|
Definition
| shuttles 2 iron molecules in blood |
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Term
|
Definition
| binds Transferrin, unloads Fe in lysosomes |
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|
Term
| porphobilinogen deaminase |
|
Definition
| defected in acute intermittent porphyria |
|
|
Term
| uroporphyrinogen decarboxylase |
|
Definition
| defective in porphyria cutanea tarda |
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|
Term
|
Definition
| actively binds ferroportin for internalization, iron not released from gut cells or macrophages, defective in hereditary hemochromatosis, induced by IL-6 in acute phase response |
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Term
|
Definition
| induces hepcidin and other acute phase proteins, lowers serum Fe |
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Term
|
Definition
| stores O2 in muscle, primarily a-helices |
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Term
|
Definition
|
|
Term
|
Definition
| fetal hemoglobin, binds O2 more tightly, HgF |
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Term
|
Definition
| adult minor hemoglobin, HgA2 |
|
|
Term
| 2,3-bisphosphoglycerate (DPG) |
|
Definition
| irreversibly binds B chains of hemoglobin in de-oxy form |
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Term
|
Definition
| initial step of heme synthesis, inhibited by heme (feedback inhibition) |
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Term
|
Definition
|
|
Term
| d-ALA dehydrase/ferrochelatase |
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Definition
|
|
Term
|
Definition
|
|
Term
| glutathione-S-transferase |
|
Definition
| neutralizes drugs with glutathione |
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|
Term
|
Definition
| responsible for streptozocin uptake |
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|
Term
|
Definition
| important in G2 to separate chromosomes for DNA synthesis |
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Term
|
Definition
| low expression in skin and lungs |
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Term
|
Definition
| inhibited by methotrexate |
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|
Term
|
Definition
|
|
Term
|
Definition
| produced in stomach by parietal cells, allows B12 absorption in terminal ileum |
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|
Term
|
Definition
| adds Fe2+ to protoporphyrin IX, inhibited by Pb2+ |
|
|
Term
|
Definition
| due to B6 Glu-Val mutation |
|
|
Term
|
Definition
| due to B6 Glu-Lys mutation |
|
|
Term
|
Definition
| due to B26 Glu-Lys mutation |
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|
Term
|
Definition
| binds ankyrin/band 3, deficient in hereditary spherocytosis |
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|
Term
|
Definition
| reduces NADP, regenerates glutathione to scavenge ROS |
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Term
|
Definition
| decay-accelerating factor, bound to PIG |
|
|
Term
|
Definition
| membrane inhibitor of active lysis, limits C3 convertase, bound to PIG |
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Term
|
Definition
|
|
Term
| CD59, CD55, C8-binding protein |
|
Definition
| bound to PIG, deficient in paroxysmal nocturnal hemoglobinuria |
|
|
Term
|
Definition
| binds sialyl Lewis X/PSGL, for leukocyte rolling |
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|
Term
|
Definition
| binds sialyl lewis X, for rolling and adhesion to activated ECs |
|
|
Term
|
Definition
| binds CD11/CD18, for adhesion/arrest/transmigration |
|
|
Term
|
Definition
| binds a4B1/a4B7, for adhesion of eosinophils/monocytes/lymphocytes |
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|
Term
|
Definition
| binds L-selectin, for lymphocyte homing |
|
|
Term
|
Definition
| binds CD31, for leukocyte migration in endothelium |
|
|
Term
|
Definition
| contributes to oxidative burst, deficient in chronic granulomatous disease |
|
|
Term
|
Definition
| directs macrophages to inflammation and tissue injury |
|
|
Term
|
Definition
| directs macrophages to repair damaged tissues |
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