Term
|
Definition
|
|
Term
| anticoagulant in pregnancy |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| advantage of LMW heparins |
|
Definition
|
|
Term
|
Definition
| heparin binds factor 4, causing ab production that binds to and activates platelets, leading to their clearance and resulting in a thrombocytopenic, hyper coagulable state |
|
|
Term
| used in patients with HIT |
|
Definition
|
|
Term
| direclty inhibit thrombin |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| teratogenic, bleeding, skin/tissue necrosis |
|
|
Term
| Hep vs warfarin: small lipid soluble |
|
Definition
|
|
Term
| Hep vs warfarin: large, anionic |
|
Definition
|
|
Term
| Hep vs warfarin: parenteral |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Hep vs warfarin: acute onset |
|
Definition
|
|
Term
| Hep vs warfarin: chronic onset |
|
Definition
|
|
Term
| Hep vs warfarin: crosses placenta |
|
Definition
|
|
Term
|
Definition
| streptokinase, urokinase, tPA and anistreplase |
|
|
Term
| convert plasminogen to plasmin |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| active bleeding, intracranial bleed, recent surgery, bleeding diatheses, or severe hypertension |
|
|
Term
|
Definition
| vinca alkaloids and taxols |
|
|
Term
|
Definition
|
|
Term
|
Definition
| etopside, antimetabolites |
|
|
Term
| inhibit nucleotide synthesis |
|
Definition
|
|
Term
|
Definition
| alkylatig agents, cisplatin dactomycin, doxorubicin, etopside |
|
|
Term
| inhibit cellular division |
|
Definition
| vinca alkaloids, paclitaxel |
|
|
Term
|
Definition
|
|
Term
| leukemias, lymphomas, choriocarcinoma and sarcomas |
|
Definition
|
|
Term
| abortion, ectopic pregnancy, RA, psoriasis |
|
Definition
|
|
Term
| reversible with leucovorin |
|
Definition
|
|
Term
| fatty liver change, mucositis, teratogenic |
|
Definition
|
|
Term
|
Definition
|
|
Term
| inhibits thymidylate synthase |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| metabolized by xanthine oxidase |
|
Definition
|
|
Term
| bone marrow depression, liver |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| antitumor abx that intercalates DNA |
|
Definition
|
|
Term
| wilm's tumor, ewing, rhabdomyosarcima |
|
Definition
|
|
Term
| generates free radical -> noncovalently intercalate in DNA |
|
Definition
|
|
Term
|
Definition
|
|
Term
| how prevent cardiotoxicity with doxorubicin? |
|
Definition
|
|
Term
| free radical formation -> breacks in DNA |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| inhibits topoisomerase II |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| busulfan, imanitib, hydroxyurea |
|
|
Term
|
Definition
|
|
Term
| inhibits microtubule assembly |
|
Definition
|
|
Term
| wilm's choriocarcinoma, ALL |
|
Definition
|
|
Term
|
Definition
|
|
Term
| MT inhibitor with myelosuppression |
|
Definition
|
|
Term
| inhibits tubulin disassembly |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| how prevent nephrotoxicity with cisplatin? |
|
Definition
| amifostine and chloride diuresis |
|
|
Term
| inhibits ribonucleotide reductase |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| cushing like, immunosuppression, cataracts, acne, osteoporosis, HTN, peptic ulcers, hyperglycemia and psychosis |
|
|
Term
| blocks biding of estrogen to estrogen receptors |
|
Definition
|
|
Term
| may increase risk of endometrial cancer |
|
Definition
| tamoxifene; NOT raloxifene |
|
|
Term
| monoclonal ab to Her-2 neu |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
