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Hematology and Oncology
Physiology
19
Physiology
Graduate
01/17/2014
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Term
intrinsic pathway
 Definition
12-11-9-8-10
Term
extrinsic pathway
 Definition
TF -7-10
Term
prokallitrien activation
 Definition
by 12, --> HMWK -> bradykinin and plaminogen -> plasmin
Term
vitamin k factors
 Definition
2,7,9,10, protein c and s
Term
ATIII factors
 Definition
2,7,9,10,11,12
Term
action of protein c and s
 Definition
cleaves 5 and 8
Term
action of plasmin
 Definition
cleavage of fibrin mesh
Term
bradykinin functions
 Definition
increase vascular permeability, vasodilation, increased pain
Term
platelet plug formation
 Definition
injury -> adhesion -> ADP adheres and activation occurs -> aggregation
Term
pro-aggregation factor
 Definition
TXA2
Term
anti-aggregation factors
 Definition
PGI2 and NO
Term
receptor on platelets for adhesion
 Definition
GPIb
Term
receptor on platelets for aggregation
 Definition
GpIIb/IIIa
Term
mediates platelet to endothelial adhesion
 Definition
vWF
Term
inhibits COX
 Definition
ASA
Term
inhibit ADP-induced expression of GpIIb/IIIa
 Definition
ticlopidina and clopidogrel
Term
binds GpIIb/IIIa directly
 Definition
abciximab
Term
increased ESR
 Definition
infetions, inflammatory disease, malignant neoplasms, GI disease
Term
decreased ESR
 Definition
polycythemia, sickle cell anemia, congestive heart failure, microcytosis, hypofibrinogenemia
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