Term
|
Definition
| The arrest of cleeding and the maintenance of vascular patency |
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|
Term
|
Definition
| Formation of platelet plug |
|
|
Term
|
Definition
| formed in the bone marrow by ‘budding’ from megakaryocytes |
|
|
Term
Vascular component
Thrombocytopenia
Von willebrand factors |
|
Definition
| Causes of failure of platelet plug formation |
|
|
Term
Bruising, purpura
Mucosal bleeding
Intracranial and retinal haemorrhages |
|
Definition
| Consequences of platelet plug formation |
|
|
Term
|
Definition
| Example of failure of fibrin clot formation as a result of Single clotting factor deficiency |
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|
Term
| Factor VIII - IXa - Activated Partial Thomboplastin time (APTT) |
|
Definition
| Screening tests for fibrin clot formation for the INTRINSIC pathway |
|
|
Term
| Factor V11a - Tissue Factor - Prothrombin Time (PTT) |
|
Definition
| Screening tests for fibrin clot formation for the EXTRINSIC pathway |
|
|
Term
|
Definition
| Type of anticoagulant important in inhibition of the terminal proteins of the cascade |
|
|
Term
|
Definition
| Increases activity of anti-thrombin On interaction |
|
|
Term
|
Definition
| Vitamin K dependant plasma protein which inactivates co factors Va and VIIIa as well as stimulating fibrinolysis |
|
|
Term
|
Definition
| Deficiency of naturally occuring anticoaqulants. Sufferers have increawed tendency of developing DVT |
|
|
Term
|
Definition
| Time effected my haemophillia |
|
|
Term
stasis
vessel wall
Hypercoagulability |
|
Definition
| Three components of Virchows triad |
|
|
Term
|
Definition
| Treatment of venous thrombosis |
|
|
Term
| Hot. swollen tender limbs with pitting oedema |
|
Definition
| Symptoms of venous thrombosis |
|
|
Term
Pulmonary infarction
Chest pain
Hypoxia
Right heart strain
CardioVascular collaspe |
|
Definition
| Pulmonary embolism can lead to |
|
|
Term
|
Definition
| Important in switching on/amplification of the intrinsic pathway |
|
|
Term
|
Definition
| Anticoagulent drug which allows anti-thrombin to bind to its target, stabilising the structure |
|
|
Term
|
Definition
| Monitoring used for heparin |
|
|
Term
Bleeding - overdose
Heparin induced thrombocytopenia
Osteoporosis - long term use |
|
Definition
|
|
Term
|
Definition
| Used in severe bleeding caused by heparin overdose, reverses anti-thrombin effect |
|
|
Term
|
Definition
| Anticoagulant that works by antagonising Vitamin K |
|
|
Term
|
Definition
| More Warfarin = less VII + X present which does what to PT |
|
|
Term
|
Definition
| Equation used to monitor patients on warfarin |
|
|
Term
|
Definition
| Adverse effects of warfarin |
|
|
Term
|
Definition
| Plaque ruptures, platelets adhere, in high pressure environment, causes damage to endothelium |
|
|
Term
Hypertension
Smokinh
High cholesterol
Diabetes |
|
Definition
| Risk factors of Arterial thrombosis |
|
|
Term
Thrombolysis
Antiplatelet drugs - Aspirin and clopidogrel |
|
Definition
| Treatment of Arterial Thrombosis |
|
|
Term
|
Definition
| occurs in low pressure system mainly by stasis and platelets are not activated, slow onset |
|
|
Term
|
Definition
| Stasis in venous thrombosis activates th coagulation cascade forming a clot rich in |
|
|
Term
Obesity
Malignancy
Pregnancy
Surgery
Immobility
Anything resulting in stasis |
|
Definition
| Risk factors for venous thrombosis |
|
|
Term
| Anticoagulant drugs - warfarin , heparin |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Elevated D-dimers are an indicator of |
|
|
Term
| The Factor V Leiden mutation (activated protein C resistance) |
|
Definition
| the commonest known cause of inherited thrombophilia. |
|
|
Term
|
Definition
| can cause cerebral malaria and death |
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|
