Term
| carbonic anhydrase inhibitors |
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Definition
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Term
| carbonic anhydrase inhibitors work at... |
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Definition
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Term
| MOA for carbonic anhydrase inhibitors |
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Definition
| prevent formation of H+ and HCO3-->less H+ to exchange for Na+-->less Na+ reabsorbed-->less water reabsorbed |
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Term
| used for open angle glaucoma, metabolic alkalosis, and high altitude sickness |
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Definition
| carbonic anhydrase inhibitors |
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Term
| side effect of carbonic anhydrase inhibitors |
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Definition
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Term
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Definition
mannitol
glycerin
urea
isosorbide |
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Term
| osmotic diuretics work at... |
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Definition
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Term
| create osmotic gradient that favors water retention in the tubular lumen |
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Definition
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Term
| used to treat acute renal failure, reduce CSF volume and pressure after head injury, glaucoma, and hemodialysis |
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Definition
| osmotic diuretics (Mannitol) |
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Term
| potential side effect is exacerbation of cardiac failure and/or pulmonary edema |
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Definition
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Term
| Which osmotic diuretic cannot penetrate cell membranes? |
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Definition
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Term
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Definition
furosemide
bumetanide
torsemide |
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Term
| loop diuretics work at... |
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Definition
| thick ascending loop of Henle |
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Term
| diuretics that act on Na-K-Cl symporter |
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Definition
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Term
| diuretics that inhibit Na and Cl reabsorption and increase Ca and K excretion |
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Definition
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Term
| used in acute reanl failure (esp. in severe cases), hypercalcemia, hyperkalemia, and HTN only if others have failed |
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Definition
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Term
| Which diuretics can cause agranulocytosis, neutropenia, thrombocytopenia, and hypomagnesemia? |
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Definition
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Term
| used when high doses of furosemide are ineffective in heart failure |
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Definition
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Term
| close evaluation of K and creatnine necessary |
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Definition
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Term
| loop diuretic drug interactions |
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Definition
aminoglycosides
digitalis
warfarin
sulfonylureas
lithium
NSAIDs
thiazides (watch for hypokalemia) |
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Term
| Which loop diuretic has the least stable bioavailability? |
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Definition
| furosemide (can be reduced in conditions such as abdominal volume retention) |
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Term
|
Definition
hydrochlorothiazide
chlorothiazide
chlorthalidone
metolazone
indapamide |
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Term
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Definition
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Term
| diuretics that inhibit Na-Cl symporter |
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Definition
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Term
| diuretic that inhibits Na reabsorption (less than loops) and increases Ca reabsorption |
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Definition
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Term
| cause decreased preload and afterload, and decreased PVR after a few weeks |
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Definition
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Term
| "thiazide-like" diuretics |
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Definition
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Term
| diuretics that can cause hypokalemia, hypercalcemia, hyponatremia with hypovolemia, hyperglycemia, ED, increased serum cholesterol, and allergic reaction |
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Definition
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Term
| thiazide drug interactions |
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Definition
lithium
digoxin
oral meds for DM |
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Term
| potassium sparing aldosterone antagonists |
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Definition
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Term
| potassium sparing ENaC antagonists |
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Definition
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Term
| potassium sparing diuretics work at... |
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Definition
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Term
| used to prevent K loss (either from side effect of thiazide/loop or hyperaldosteronism) |
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Definition
| potassium sparing diuretics |
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Term
| greater effect in cirrhotic pts than furosemide |
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Definition
| potassium sparing diuretics |
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Term
| useful in long term management of HF |
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Definition
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Term
| diuretic approved for post-MI CHF |
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Definition
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Term
| potassium sparing diuretics take how long to start acting |
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Definition
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Term
| side effects of spironolactone |
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Definition
| hyperkalemia (esp. with ACE inhibitors, NSAIDs), anti-androgen effect |
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Term
| spare K by decreasing the lumen-negative gradient that drives the expulsion of K/H into the lumen |
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Definition
| potassium sparing ENaC antagonists |
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Term
| side effect of nephrolithiasis |
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Definition
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Term
|
Definition
conivaptan
desmopressin (DDAVP) |
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Term
|
Definition
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Term
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Definition
| mimic ADH (vasopressin)--retention hormone |
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Term
| used for central diabetes insipidus and hyponatremia (as in SIADH) |
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Definition
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Term
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Definition
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Term
| causes less dry mouth than it's counterpart but does cause erythema and pruritis |
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Definition
| oxytrol patch (oxybutynin transdermal) |
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Term
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Definition
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Term
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Definition
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Term
| OAB drug that is less likely to pass through BBB and therefore has fewer side effects |
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Definition
| trospium chloride (Sanctura) |
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Term
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Definition
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Term
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Definition
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Term
| OAB drug that is M3 selective |
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Definition
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Term
| major side effect of alpha blockers |
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Definition
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Term
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Definition
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Term
| Which alpha blocker may have LDL lowering effect? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Which BPH drug is alpha 1A selective? |
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Definition
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Term
| BPH drug that has very little vascular side effects |
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Definition
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Term
| alpha blocker rarely used for BPH |
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Definition
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Term
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Definition
| competitive antagonists that block sympathetic tone and allow bladder to relax |
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Term
| 5-alpha reductase inhibitors |
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Definition
finasteride (Proscar)
dutasteride |
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Term
| Which 5-alpha reductase inhibitor is type 2 selective? |
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Definition
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Term
| used for BPH to reduce the size of the prostate and for alopecia |
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Definition
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Term
| What do you need to do before starting pt on finasteride? |
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Definition
| get PSA (will go down after treatment) |
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Term
| Women who are pregnant or who may become pregnant should not handle... |
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Definition
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Term
| After taking finasteride, one cannot donate blood for ___ months after stopping treatment. |
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Definition
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Term
| 5-alpha reductase inhibitors have a fast/slow onset |
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Definition
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Term
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Definition
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Term
| side effect of saw palmetto |
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Definition
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Term
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Definition
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Term
| used for post-op urinary retention and neurogenic bladder |
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Definition
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Term
| bethanechol contraindications |
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Definition
asthma
bradycardia
PUD
epilepsy/Parkinsonism |
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Term
| Why does bethanechol have a long duration of action? |
|
Definition
| not hydrolyzed effectively by cholinesterase |
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Term
|
Definition
sildenafil
vardenafil
tadalafil |
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Term
|
Definition
| increase cGMP that promotes and sustains smooth muscle relaxation and reduce metabolism of cGMP |
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Term
| Which PDE-5 inhibitor is best for post-radical-prostatectomy and diabetic pts? |
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Definition
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Term
| can cause bright vision and/or blue-green halo around vision |
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Definition
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Term
| Which PDE-5 inhibitor has increased occurrence of priapism? |
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Definition
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Term
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Definition
pts taking organic nitrites (sublingual NG, isosorbide)
severe coronary disease (stress test first) |
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Term
| PDE-5 inhibitor that works best on empty stomach |
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Definition
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Term
| longest lasting PDE-5 inhibitor that is not affected by food/fatty meals |
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Definition
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Term
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Definition
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Term
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Definition
| enhances central natural erectile signals that normally occur in the brain |
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Term
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Definition
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Term
| vasoactive prostaglandin E1 |
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Definition
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Term
| most commonly prescribed drug for FSD |
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Definition
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Term
| side effect of testosterone in women |
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Definition
masculinization
liver toxicity in high doses |
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Term
| relieves menopausal symptoms (vaginal dryness, itching, discomfort) |
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Definition
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Term
| women's version of viagra |
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Definition
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Term
|
Definition
| topical that causes clitoral stimulation by vasodilation |
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