Term
| MOA of allopurinol and febuxostat |
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Definition
xanthine oxidase inhibitors (block UA production) |
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Term
| How should coclchicine be used during initial uric acid lowering therapy? |
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Definition
Use colchicine or NSAIDs for at least 6 months to reduce the risk of acute flares when beginning UA - lowering acid therapy. |
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Term
| Brand name for Allopurinol |
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Definition
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Term
| Brand name for Febuxostat |
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Definition
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Term
| Allpurinol side effects of note? |
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Definition
precipitation of acute attacks
nausea
skin rash (can lead to SJS) |
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Term
| Why isn't febuxostat used often |
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Definition
much more expensive than allopurinol (20k more/year). It may be safer in severe reneal impairment (no dose adjustment in reanlly impaired) and has a decreased risk for hypersensitivity. |
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Term
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Definition
| Statement. Not a question. |
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Term
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Definition
| Statement. Not a question. |
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Term
| Can probenecid affect renal clearance |
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Definition
Probenecid may decrease the renal clearance of other medications taken concurrently, including aspirin, methotrexate, theophylline, penicillins &c.
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Term
| Probenecid used to be given with penicillins, why? |
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Definition
Probenecid used to be given with penicillin to increase the penicillin plasma concentrations; this will increase reactions associated with the beta lactam |
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Term
How should allopurinol be used to prevent gout attacks (probenecid is uesd less commonly) |
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Definition
Once daily with a meal to reduce stomach upset |
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Term
| Are allopurinol's beneficial affects fast acting? |
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Definition
may take up to several weeks for this medicine to have an effect and one may have more gout attacks for several months after starting this medicine whilet he body removes extra uric acid.
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