Term
|
Definition
| Blocks tubulin formation and inhibits neutrophils ability to activate |
|
|
Term
|
Definition
| inhibit prostoglandin synthesis and thromboxane- NSAID |
|
|
Term
| Colchicine (Adverse and X) |
|
Definition
(-): BM supression, neuropathy, abdominal pain, nausea, diarrhea (Common)
(X)- Liver, Cardiac or Renal Disease |
|
|
Term
|
Definition
|
|
Term
|
Definition
| inhibit infammatory response (Glucocorticoids) |
|
|
Term
|
Definition
| Blocks xanthine oxidase from creating uric acid |
|
|
Term
| Allopurinol/Oxipurinol(When to use) |
|
Definition
| Chronic Gout caused by purine degradation |
|
|
Term
| Allopurinol/Oxipurinol (-) and (x) |
|
Definition
(-): rash, itching, GI disturbances, SJ Syndrome
X: Acute Attacks, Hemochromatosis |
|
|
Term
| What is usually given concurrently during gout therapy to stop acute flares? |
|
Definition
| Allopurinol + NSAID/colchine |
|
|
Term
|
Definition
| inhibits xanthine oxidase just like allopurinol |
|
|
Term
| Febxostat how does it differ from allopurinol |
|
Definition
| may not require dose adjustment in kidney insufficent patients, and no skin reactions |
|
|
Term
| Febuxostat similarities to allopurinol |
|
Definition
| should be combined with cholchine or NSAID for first few months |
|
|
Term
| Probenecid/Sulfinpyrazone(MOA) |
|
Definition
| increase renal excretion of uric acid thru URAT1 and OATS (Penicillan excretion) |
|
|
Term
| Probencid and Sulfinpyrazone (-) and (x) |
|
Definition
TCP, bronchiospasm, aplastic anemia, hepatic necrosis, anaphylaxis, GI issues
(x) acute gout, kids under 2, uric acid kidney stones, |
|
|
Term
|
Definition
| Angiotension II receptor antagonist for hypertension and gout |
|
|
Term
|
Definition
(-): angioedema, rhabdomyolysis, TCP, fatigue, back pain, hypoglycemia
(X): Pregnancy |
|
|
Term
| Rasburicase/Pegloticase (MOA) |
|
Definition
| exogenous uricase that can breakdown uric acid to allantonin |
|
|
Term
| When to use Rasburicase/Pegloticase |
|
Definition
| Tumor Lysis and Gout respectively |
|
|
Term
| Rasburicase and Pegloticase - and x |
|
Definition
-: Rash, GI, Fever, Sepsis, Resp. Distress
x: G6PD deficency, Aspergillus sensitivity |
|
|
